The DNA Damage Response in Human Disease
Travis Stracker (IRB Barcelona) and John H. J. Petrini, Memorial Sloan-Kettering Cancer Center (USA)
Barcelona, Spain. 28-30 May, 2012
The cellular DNA damage response (DDR) is activated following the detection of DNA lesions with the goal of protecting the integrity of genetic information. The DDR is a composite of cell cycle checkpoints, DNA repair, transcriptional programs, and in some cases apoptosis or senescence. Defects in the DDR, particularly the response to DNA double-strand breaks, underlie many human hereditary diseases that lead to severe pathological outcomes that include neurodegeneration, microcephaly, immodeficiency, anemia and increased predisposition to cancer. Understanding how defects in the DDR cause these various human pathologies remains an active area of investigation that will yield new insights in to the etiology of complex human diseases and inform treatment regimens.
This conference brings together experts in the DNA damage response to discuss recent advances in the field and their relationship to human disease. The number of participants will be limited to facilitate discussion of key issues and interactions between participants.
Registration deadline: May 6, 2012
There is no registration fee for this conference, but the number of participants is limited.
Participants are invited to submit abstracts, a number of which will be selected for short talk and poster presentations. Abstracts should include a title, authors, affiliations, summary (max 250 words) and references.
The BARCELONA BIOMED CONFERENCE on The DNA damage response in human disease will be hosted by the Institut d'Estudis Catalans (IEC) in the heart of downtown Barcelona. Talks will take place in the Sala Prat de Riba.
Institut d'Estudis Catalans
C. del Carme, 47
Tel +34 932 701 620
Fax +34 932 701 180
How to reach the IEC:
From Barcelona El Prat airport:
A taxi from the airport to the IEC should take about 25 minutes and cost around 25-30 euros depending on traffic and luggage.
The RENFE train leaves the airport every half an hour and will take you to Passeig de Gracia station, in about 25 mins and costs 2.80 Euros for a single ticket. Change here for the Green Line metro to Liceu. The IEC is a 10-minute walk from the metro station (see map).
A transfer service called "Aerobus" will also take you from the airport to Plaça Catalunya and costs 4.25 Euros. The journey time is around 30 minutes. The IEC is a 10-minute walk from the Plaça Catalunya (see map).
From Girona airport:
The "Barcelona bus" runs a transfer service between Girona Airport and Barcelona's city centre, scheduled to coincide with Ryan Air flights. The bus stops right outside the airport and will take you to Estacio d'Autobusos Barcelona Nord (Barcelona's main bus terminal), with a journey time of about 1 hr 10 min. The nearest Metro stop to the bus station is Arc De Triomf, which is a 5-10 minute walk from the bus station (exit the bus station Sortida Nàpols). Take the Red Line (L1) to Plaça Catalunya. The IEC is a 10-minute walk from the Plaça Catalunya (see map).
From Sants train station:
Transfer to the metro Red Line (L1), and get off at laça Catalunya. The IEC is a 10-minute walk from the Plaça Catalunya (see map).
If you are arriving locally:
Plaça Catalunya (lines 1 and 3)
Liceu (line 3)
Plaça Catalunya (train from Sarrià)
41, 55, 141 (Plaça Catalunya stop)
14, 18, 59, 91 (Rambla stop)
Barcelona Metropolitan Transport webiste (with metro and bus maps)
Speakers will be lodged at the Hotel Catalonia Ramblas
c/ Pelayo, 28
Telephone: +34 93 316 84 00
Fax: +34 93 316 84 01
A list of additional hotels within walking distance of the IEC can be found at: http://www.barcelona-tourist-guide.com/en/hotels/hotelmaps/ramblas-hotel-barcelona.html (The IEC is located near the blue point 08/5 star). Rates will vary depending on choice of hotel and season. Please check with the hotel of your choice directly for the best offer.
Another possibility is the Residencia dels Investigadors (Investigators Residence Hall), which has an agreement with the CSIC (Spanish National Research Council) and the Catalan Government. It is located just behind the IEC, and is available for short-term stays. Rates (valid from 01/10/08- 31/08/09) range between 51-68 euros for a single room, to 71-94 euros for a double room.
Residencia dels Investigadors
C/ Hospital, 64
Telephone: +34 93 443 86 10
Fax: +34 93 442 82 02
Participants registered for events in the Barcelona BioMed series should contact the hotels and residences directly to arrange bookings and payment.
- Travis Stracker, IRB Barcelona (Barcelona, Spain)
- John H. J. Petrini, Memorial Sloan-Kettering Cancer Center (NY, USA)
- Andrés Aguilera, Andalusian Centre for Molecular Biology and Regenerative Medicine (Seville, Spain)
- David Cortez, Vanderbilt University (Nashville, TN, USA)
- Vincenzo Costanzo, London Research Institute (London, UK)
- Daniel Durocher, Samuel Lunenfeld Research Institute (Toronto, Canada)
- Oskar Fernandez Capetillo, Spanish National Cancer Research Centre, (Madrid, Spain)
- Monica Gostissa, Harvard Medical School (Boston, MA, USA)
- Neil Hunter, University of California (Davis, CA, USA)
- Stephan Jentsch, Max Planck Institute of Biochemistry (Munich, Germany)
- Jos Jonkers, The Netherlands Cancer Institute (Utrecht, the Netherlands)
- Stephen C. Kowalczykowski, University of California, (Davis, CA, USA)
- Eros Lazzerini-Denchi, The Scripps Research Institute (La Jolla, CA, USA)
- Jiri Lukas, Centre for Genotoxic Stress Research (Copenhagen, Denmark)
- Peter McKinnon, St. Jude Children's Research Hospital (Memphis, TN, USA)
- KJ Patel, MRC Laboratory of Molecular Biology (London, UK)
- Patrick Sung, Yale University (New Haven, USA)
- Jordi Surrallés, Autonomas University of Barcelona (Barcelona, Spain)
- Lorraine Symington, Columbia University (New York, NY, USA)