Spain will become a full member of ELIXIR, the European bioinformatics infrastructure created to optimise biological data obtained from life sciences research.
The 18 research centres holding the “Severo Oc
Malaria is one of the most serious health problems worldwide, registering 200 million clinical cases and more than 600,000 attributable deaths per year, according to information from the World Heal
The European Commission has awarded the Institute for Research in Biomedicine (IRB Barcelona) the “HR Excellence in
TV3 - TN Migdia/ 3/24
Coinciding with the announcement by the WHO about a 50% decrease in number of cases of malaria, TV3 also explains IRB’s discovery of compounds that eliminate malaria in mice. ICREA researcher Lluís Ribas de Pouplana further explains that the treated mice developed an immune memory that protects against future infections.
“La Sexta Columna” television programme has broadcasted a report about the initiative taken by families with relatives that suffer from Friedreich’s Ataxia, a rare illness with no cure. Joined in an association called Genefa, these families raised the funds necessary to launch a research project – involving IRB Barcelona - to find a treatment.
Cadena Ser radio, like other national and international media, has reported on the results obtained by Lluís Ribas’s team on new borrelidin-based compounds to combat the malaria-causing parasite Plasmodium. This study, published in the PNAS journal, was performed in mice, and showed that the compounds were 100% effective.
«Our study highlights the complexity of p38 functions, both in cancer and in the maintenance of normal tissues. It shows why an inhibitor of this molecule could effectively have undesirable side effects. But these do not exclude it from being a target against cancer.»
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«Controlling a biological process from outside is the future of chemistry and opens up promising roads for advancements in pharmacological research.»
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Felice Alessio Bava
ex PhD student in the Translational Control of Cell Cycle and Differentiation Lab
«We suspected that CPEB1, a protein involved in regulating mRNA translation in the cytoplasm, might also be active in the nucleus and play a role in controlling pre-mRNA processing. We discovered that it affects the alternative generation in the mature mRNA of the 3'-UTR, regions where most of the elements regulating translation in time and space are located.»
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«98% of the potential therapeutic molecules against diseases of the central nervous system cannot cross the blood-brain barrier. We develop peptides with the capacity to open the doors of the barrier and act as shuttles when attached to a therapeutic molecule.»
Quick facts about IRB
IRB Barcelona is home to nearly 450 research, technical and support staff from 35 countries who share the common goal of contributing to the advancement of the biomedical sciences through investigator–driven research, and improving quality of life by applying advances in this field.
The convergence of biology, chemistry, and structural and computational biology is unique at IRB Barcelona and opens a strategic window to gain insight into basic molecular processes in health and disease.
Research is conducted by 23 groups organized into 5 interdisciplinary programmes. Each programme includes a diverse faculty of researchers with overlapping scientific interests. The research areas have been structured to be highly interactive, fostering multidisciplinarity by combining modern molecular biology, classical genetics, biochemistry, structural biology, bioinformatics, systems biology, advanced microscopy, and genomic and proteomic approaches.