Speaker: Dr. Jose Rizo-Rey,
UT Southwestern Medical Center Dallas, USA

Organizer: Chemistry & Molecular Pharmacology Programme, IRB Barcelona
Host: Dr. Ernest Giralt, IRB Barcelona
Date: Thursday, 26 January 2012, 09:30h
Place: Aula Fèlix Serratosa, Parc Cièntific de Barcelona, Spain

Selected Publications

• X. Shao, B. A. Davletov, R. B. Sutton, T. C. Südhof and J. Rizo, “A Bipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C”, Science 273, 248-251 (1996).

• I. Fernandez, J. Ubach, X. Zhang, T. C. Südhof and J. Rizo, “Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A”, Cell 18, 841-849 (1998).

• R. Fernandez-Chacon, A. Königstorfer, S. H. Gerber, J. Garcia, M. F. Matos, C. F. Stevens, N. Brose, J. Rizo, C. Rosenmund and T. C.Südhof, “Synaptotagmin I functions as a Ca2+-regulator of release probability”, Nature 410, 41-49 (2001).
  

• D. Araç, X. Chen, H. A. Khant, J. Ubach, S. J. Ludtke, M. Kikkawa, A. E. Johnson, W. Chiu, T. C. Südhof and J. Rizo, “Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin 1 to phospholipids”, Nat. Struct. Molec. Biol. 13, 209-217 (2006).

• Sheard, L.B., Tan, X., Mao, H., Withers, J., Nissan, G.B., Hinds, T.R., Hsu, F.-F., Sharon, M., Browse, J., He, S.Y., Rizo, J., Howe, G.A. and Zheng, N. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature 468, 400-405 (2010).

• Kaeser, P.S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo J. and Sudhof, T.C. RIM proteins tether Ca2+-channels to presynaptic active zones via a direct PDZ-domain interaction. Cell 144, 282-295 (2011).

• Ma, C., Li, W., Xu, Y. and Rizo, J. Munc13 mediates the transition from the closed syntaxin/Munc18 complex to the SNARE complex, Nat. Struct. Mol. Biol. 18, 542-549 (2011).

• Brewer, K.D., Li, W., Horne, E.B. and Rizo J. Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc. Natl. Acad. Sci. USA 108, 12723-12728 (2011).