Programes de Recerca
Biologia Estructural i Computacional
irbbarcelona.org
Bioinformàtica Estructural i Biologia de Xarxes
Novel peptide-mediated interactions derived from high-resolution 3-dimensional structures
Stein A and Aloy P
PLoS Comput Biol, 6 (5), e1000789 (2010)
Unveiling the role of network and systems biology in drug discovery
Pujol A, Mosca R, Farrés J and Aloy P
Trends Pharmacol Sci, 31 (3), 115-123 (2010)
Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Littler DR, Alvarez-Fernández M, Stein A, Hibbert RG, Heidebrecht T, Aloy P, Medema RH and Perrakis A
Nucleic Acids Res, 38 (13), 4527-4538 (2010)
Predicting protein-protein interaction specificity through the integration of three-dimensional structural information and the evolutionary record of protein domains
Panjkovich A and Aloy P
Mol Biosyst, 6 (4), 741-749 (2010)
Dynamic interactions of proteins in complex networks: a more structured view
Stein A, Pache RA, Bernadó P, Pons M and Aloy P
FEBS J, 276 (19), 5390-5405 (2009)
Splitting statistical potentials into meaningful scoring functions: testing the prediction of near-native structures from decoy conformations
Aloy P and Oliva B
BMC Struct Biol, 9, 71 (2009)
A network medicine approach to human disease
Zanzoni A, Soler-López M and Aloy P
FEBS Lett, 583 (11), 1759-1765 (2009)
Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions
Pache RA, Babu MM and Aloy P
BMC Syst Biol, 3, 74 (2009)
Pushing structural information into the yeast interactome by high-throughput protein docking experiments
Mosca R, Pons C, Fernández-Recio J and Aloy P
PLoS Comput Biol, 5 (8), e1000490 (2009)
3did Update: domain-domain and peptide-mediated interactions of known 3D structure
Stein A, Panjkovich A and Aloy P
Nucleic Acids Res, 37, D300-304 (2009)
Incorporating high-throughput proteomics experiments into structural biology pipelines: identification of the low-hanging fruits
Pache RA and Aloy P
Proteomics, 8 (10), 1959-1964 (2008)
Towards a molecular characterisation of pathological pathways
Pache RA, Zanzoni A, Naval J, Mas JM and Aloy P
FEBS Lett, 582 (8), 1259-1265 (2008)
A molecular interpretation of genetic interactions in yeast
Stein A and Aloy P
FEBS Lett, 582 (8), 1245-1250 (2008)
Approved drug mimics of short peptide ligands from protein interaction motifs
Parthasarathi L, Casey F, Stein A, Aloy P and Shields DC
J Chem Inf Model, 48 (10), 1943-1948 (2008)
Contextual specificity in peptide-mediated protein interactions
Stein A and Aloy P
PLoS ONE, 3 (7), e2524 (2008)
Targeting and tinkering with interaction networks
Russell RB and Aloy P
Nat Chem Biol, 4 (11), 666-673 (2008)
Shaping the future of interactome networks
Aloy P
Genome Biol, 8 (10), 316 (2007)
Structural systems biology: modelling protein interactions
Aloy P and Russell RB
Nat Rev Mol Cell Biol, 7 (3), 188-197 (2006)
Proteome survey reveals modularity of the yeast cell machinery
Gavin AC, Aloy P et al
Nature, 440 (7084), 631-636 (2006)
Target selection for complex structural genomics
Bravo J and Aloy P
Curr Opin Struct Biol, 16 (3), 385-392 (2006)
Discovery and hypothesis generation through bioinformatics
Dopazo J and Aloy P
Genome Biol, 7 (2), 307 (2006)
Ten thousand interactions for the molecular biologist
Aloy P and Russell RB
Nat Biotechnol, 22 (10), 1317-1321 (2004)
Structure-based assembly of protein complexes in yeast
Aloy P et al
Science, 303 (5666), 2026-2029 (2004)
Interrogating protein-interaction networks through structural biology
Aloy P and Russell RB
Proc Natl Acad Sci USA, 99 (9), 5896-5901 (2002)
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