Nucleic acid chemistry

Ramón Eritja

Group Leader
Professor (IQAC-CSIC)
Office Tel : +34 93 40 39942
Lab Tel : +34 93 403 99 42
e-mail : ramon.eritjairbbarcelona.org

Background

Nucleic acids (DNA and RNA), which are formed by long chains of nucleotides, play a crucial role in genetic inheritance. Oligonucleotides (small versions of nucleic acids) have been synthesized in laboratories since the 1980s. The field of nucleic acid chemistry has since undergone remarkable progress, which has been vital for the development of several disciplines such as biochemistry, molecular biology, structural biology, biotechnology, biomedicine and, in more recent years, nanoscience.

Research Interests

To synthesize oligonucleotides and nucleic acid derivatives in order to study their properties, and also to further develop and improve techniques involving oligonucleotides.

Research Lines

Two major research lines are underway:

1) Synthesis of modified oligonucleotides to be used in the fabrication of molecular circuits based on DNA.

Since the fabrication of the first chips in the 1950s, the density of the functional units per surface unit has duplicated every 3-4 years. This advance has been achieved thanks to technological breakthroughs that have allowed circuit miniaturization. However, currently available technologies based on photolithography are reaching their physical limits. Thus, it is believed that in the near future parts of the circuits will be prepared using biomolecules, which will arrange the nanomaterials in solution while the resulting structures will be positioned in the spaces produced by photolithography. One of the promising biomolecules for this approach is DNA. In this regard, we have developed a methodology to synthesize modified oligonucleotides, which are then used to assemble nanomaterials. The most important result from this research is the selective metallization, with gold nanoparticles, of a linear DNA structure formed by synthetic oligonucleotides (Ongaro, et al. (2004) Adv. Mat., 16, 1799). We are now increasing the complexity of the system by preparing new oligonucleotide derivatives. For the functionalization of nanomaterial surfaces, we are also preparing oligonucleotides by means of molecules that have electronic properties of interest and also through the use of reactive groups.

2) Synthesis of oligonucleotides carrying 8-aminopurines and study of the stabilization properties of triple helices.

The capacity of several synthetic oligonucleotides to inhibit gene expression has generated great interest in the scientific community. This capacity makes these molecules potential therapeutic drugs for the treatment of viral infections and cancer (antisense therapy). On the basis of using triple formation, we are currently working on the development of new oligonucleotide derivatives that inhibit gene expression. We have demonstrated that the presence of 8-aminopurines stabilize triple helices. We aim to use these stabilizing properties to obtain oligonucleotides with more potent inhibitory activity. To date we have demonstrated that hairpin affinity is so high that the oligonucleotides can bind target sequences with secondary structures, thereby competing successfully with these and yielding the expected triplex.

Funding

This group receives financial support from the following sources:

• Fundació "la Caixa" ("la Caixa"  Foundation)
• European Commission
• Generalitat de Catalunya (Government of Catalonia)
• Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)

More info

• Eritja Group Scientific Report 2009
• Eritja Group Scientific Report 2008
• Eritja Group Scientific Report 2007
• Eritja Group Scientific Report 2005-2006

Nucleic acid chemistry

Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.
Terrazas M, Ocampo SM, Perales JC, Marquez VE, Eritja R.
Chembiochem., 12 (7), 1056-1065 (2011)

Branched RNA: A new architecture for RNA interference
Aviñó A, Ocampo SM, Perales JC, Eritja R.
J Nucleic Acids., 586935 (2011)

A direct, efficient method for the preparation of siRNAs containing ribo-like North bicyclo[3.1.0]hexane pseudosugars.
Terrazas M, Aviñó A, Siddiqui MA, Marquez VE, Eritja R.
Org Lett., 13 (11), 2888-2891 (2011)

Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations.
Aviñó A, Ocampo SM, Lucas R, Reina JJ, Morales JC, Perales JC, Eritja R.
Mol Divers., 15 (3), 751-757 (2011)

Acridine and quindoline oligomers linked through a 4-aminoproline backbone prefer G-quadruplex structures.
Ferreira R, Artali R, Farrera-Sinfreu J, Albericio F, Royo M, Eritja R, Mazzini S.
Biochim Biophys Acta., 1810 (8), 769-776 (2011)

Synthesis and properties of small interfering RNA duplexes carrying 5-ethyluridine residues.
Terrazas M, Eritja R.
Mol Divers., 15 (3), 677-686 (2011)

Evaluation of the structure-activity relationship of thrombin binding aptamers by voltammetry and atomic force microscopy.
Diculescu, VC, Chiorcea-Paquim, AM, Eritja, R, Oliveira-Brett, AM
J Electroanal Chem., 656 (1-2), 159-166 (2011)

Chemical equilibria studies using multivariate analysis methods
Jaumot J, Eritja R, Gargallo R
Anal. Bioanal. Chem., 399 (6), 1983-1997 (2011)

Highly polar carbohydrates stack onto DNA duplexes via CH/π interactions
Lucas R, Gómez-Pinto I, Aviñó A, Reina JJ, Eritja R, González C, Morales JC
J. Am. Chem. Soc., 133 (6), 1909-1916 (2011)

Synthesis of lipid-oligonucleotide conjugates for RNA interference studies.
Grijalvo S, Ocampo SM, Perales JC, Eritja R
Chem. Biodivers., 8 (2), 287-299 (2011)

Development of a novel fluorescence assay based on the use of the thrombin-binding aptamer for the detection of O-alkylguanine-DNA alkyltransferase activity.
Tintoré M, Aviñó A, Ruiz FM, Eritja R, Fàbrega C
J. Nucleic Acids (2010)

Structural properties of g,t-parallel duplexes.
Aviñó A, Cubero E, Gargallo R, González C, Orozco M, Eritja R.
J Nucleic Acids. (2010)

Fabrication of patterned surfaces by photolithographic exposure of DNA-hairpins carrying a novel photolabile group
Manning B, Leigh SJ, Ramos R, Preece J and Eritja R
J Exp Nanoscience, 5 (1), 26-39 (2010)

Triplex-stabilizing properties of parallel clamps carrying LNA derivatives at the Hoogsteen strand
Alvira M and Eritja R
Chem Biodivers, 7 (2), 376-382 (2010)

Stepwise synthesis of oligonucleotide-peptide conjugates containing guanidinium and lipophilic groups in their 3'-termini
Grijalvo S, Terrazas M, Aviñó A and Eritja R
Bioorg Med Chem Lett, 20 (7), 2144-2147 (2010)

Spectrometric study of the oligodeoxyribonucleotide protonation in aqueous solution
Gargallo R, Eritja R and Kudrev AG
Russ J Gen Chem, 80 (3), 485-492 (2010)

Synthesis and structural properties of G,T-parallel clamps carrying 8-aminopurine residues
Aviñó A, Cubero E, Gargallo R, González C, Orozco M, Eritja R
J. Nucleic Acids (2010)-11 pages (2010)

Synthesis and G-quadruplex binding properties of defined acridine oligomers
Ferreira R, Aviñó A, Pérez-Tomás R, Gargallo R, Eritja R
J. Nucleic Acids (2010)

Thrombin binding aptamer quadruplex formation: AFM and voltammetric characterization
Diculescu VC, Chiorcea-Paquim AM, Eritja R, Oliveira-Brett AM
J. Nucleic Acids (2010)-8 pages (2010)

Modified siRNAs for the study of the PAZ domain
Somoza A, Terrazas M, Eritja R
Chem. Commun., 46, 4270-4272 (2010)

Synthesis, cell-surface binding and cellular uptake of fluorescently labelled glucose-DNA conjugates with different carbohydrate presentation
Ugarte-Uribe B, Pérez-Rentero S, Lucas R, Aviñó A, Reina JJ, Alkorta I, Eritja R, Morales JC
Bioconjugate Chem., 21 (7), 1280-12897 (2010)

Synthesis and properties of oligonucleotides carrying isoquinoline imidazo[1,2-a]azine fluorescent units
Pérez-Rentero S, Kielland N, Terrazas M, Lavilla R, Eritja R
Bioconjugate Chem., 21 (9), 1622-1628 (2010)

Solid-phase synthesis of oligodeoxynucleotides containing N4-[2-(t-butyldisulfanyl)ethyl]-5-methylcytosine moieties
Pérez-Rentero S, Garibotti AV, Eritja R
Molecules, 15 (8), 5692-5707 (2010)

Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker
Aviñó A, Mazzini S, Ferreira R, Eritja R
Bioorg. Med. Chem., 18 (21), 7348-7356 (2010)

Synthesis of oligonucleotides carrying amino lípido groups at the 3’-end for RNA interference studies
Grijalvo S, Ocampo SM, Perales JC, Eritja R
J. Org. Chem., 75 (20), 6806-6813 (2010)

Classification of nucleic acids structures by means of the chemometric analysis of circular dichroism spectra
Jaumot J, Eritja R, Navea S and Gargallo R
Anal Chim Acta, 642 (1-2), 117-126 (2009)

Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies
Aviñó A, Ocampo S.M, Caminal C, Perales JC and Eritja R
Mol Divers, 13 (3), 287-293 (2009)

Photocleavage of peptides and oligodeoxynucleotides carrying 2-nitrobenzyl groups
Ramos R, Manning B, Aviñó A, Gargallo R and Eritja R
Helv Chim Acta, 92, 613-622 (2009)

Synthesis and hybridization properties of modified oligodeoxynucleotides carrying non-natural bases
Aviñó A, Pérez-Rentero S, Garibotti AV, Siddiqui MA, Márquez VE and Eritja R
Chem Biodivers, 6 (2), 117-126 (2009)

Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors
Martínez MT, Tseng YC, Ormategui N, Loinaz I, Eritja R and Bokor J
Nano Lett, 9 (2), 530-536 (2009)

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site
van Bemmel DM, Brank AS, Eritja R, Marquez VE and Christman JK
Biochem Pharmacol, 78 (6), 633-641 (2009)

Fluorescence site-encoded DNA addressable hapten-microarray for anabolic androgenic steroids
Tort N, Salvador JP, Eritja R, Poch M, Martínez E, Samitier J and Marco MP
Trends Anal Chem, 28, 718-728 (2009)

Targeting the G–quadruplex forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and with the complementary C-rich strand
Del Toro M, Bucek P, Aviñó A, Jaumot J, González C, Eritja R and Gargallo R
Biochemie, 91 (7), 894-902 (2009)

Alpha,gamma-Peptide nanotube templating of one-dimensional parallel fullerene arrangements
Reiriz C, Brea RJ, Arranz R, Carrascosa JL, Garibotti A, Manning B, Valpuesta JM, Eritja R, Castedo L and Granja JR
J Am Chem Soc, 131 (32), 11335-11337 (2009)

Assembly of two-dimensional DNA crystals carrying N4-[2-(tert-Butyldisulfanyl)ethyl]cytosine residues
Garibotti AV, Sisquella X, Martínez E and Eritja R
Helv Chim Acta, 92 (8), 1466-1472 (2009)

Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer
Saneyoshi H, Mazzini S, Aviñó A, Portella G, González C, Orozco M, Marquez VE and Eritja R
Nucleic Acids Res, 37 (17), 5589-5601 (2009)

Unique tautomeric and recognition properties of thioketothymines?
Faustino I, Aviño A, Marchán I, Luque FJ, Eritja R and Orozco M
J Am Chem Soc, 131 (35), 12845-12853 (2009)

The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer
Saneyoshi H, Mazzini S, Aviñó A, Portella G, González C, Orozco M, Marquez VE and Eritja R
Nucleic Acids Symp Ser, 53, 109-110 (2009)

pH-modulated Watson-Crick duplex- quadruplex equilibria of guanine-rich and cytosine-rich DNA sequences 140 bp upstream of the c-kit transcription initiation site
Bucek P, Jaumot J, Aviñó A, Eritja R and Gargallo R
Chemistry, 15 (46), 12663-12671 (2009)

Modified oligonucleotides for biosensing applications
Manning B, Pérez-Rentero S, Garibotti AV, Ramos R and Eritja R
Sensor Lett, 7, 774-781 (2009)

8-Amino guanine accelerates tetramolecular G-quadruplex formation
Gros J, Aviñó A, Lopez de la Osa J, González C, Lacroix L, Pérez A, Orozco M, Eritja R and Mergny JL
Chem Commun, 7 (25), 2926-2928 (2008)

Synthesis of oligonucleotide derivatives using ChemMatrix supports
Mazzini S, García-Martin F, Alvira M, Aviñó A, Manning B, Albericio F and Eritja R
Chem Biodivers, 5 (1), 209-218 (2008)

Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase
Dowd CL, Sutch BT, Haworth IS, Eritja R, Marquez VE and Yang AS
Nucleosides Nucleotides Nucleic Acids, 27 (2), 131-145 (2008)

Protecting groups for RNA synthesis: an increasing need for selective preparative methods
Somoza A
Chem Soc Rev, 37 (12), 2668-2675 (2008)

Study of the interaction between the G-quadruplex-forming thrombin-binding aptamer and the porphyrin 5,10,15,20-tetrakis-(N-methyl-4-pyridyl)-21,23H-porphyrin tetratosylate
Del Toro M, Gargallo R, Eritja R and Jaumot J
Anal Biochem, 379 (1), 8-15 (2008)

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
Aviñó A, Navarro I, Farrera-Sinfreu J, Royo M, Aymamí J, Delgado A, Llebaria A, Albericio F and Eritja R
Bioorg Med Chem Lett, 18 (7), 2306-2310 (2008)

Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones
Farrera-Sinfreu J, Aviñó A, Navarro I, Aymamí J, Beteta NG, Varón S, Pérez-Tomás R, Castillo-Avila W, Eritja R, Albericio F and Royo M
Bioorg Med Chem Lett, 18 (7), 2440-2444 (2008)

Synthesis of oligonucleotide conjugates carrying viologen and fluorescent compounds
Alvira M, Quinn SJ, Aviñó A, Fitzmaurice D and Eritja R
The Open Org Chem J, 2, 41-45 (2008)

Experimental measurement of carbohydrate-aromatic stacking in water by using a dangling-ended DNA model system
Morales JC, Reina JJ, Díaz I, Aviñó A, Nieto PM and Eritja R
Chemistry, 14 (26), 7828-7835 (2008)

A straightforward protocol for the solution-phase parallel synthesis of ceramide analogues
Grijalvo S, Matabosch X, Llebaria A and Delgado A
Eur J Org Chem, 1, 150-155 (2008)

Steric effects in RNA interference: probing the influence of nucleobase size and shape
Somoza A, Silverman AP, Miller RM, Chelliserrykattil J and Kool ET
Chemistry, 14 (26), 7978-7987 (2008)

Solid-phase synthesis of modified oligonucleotides
Eritja R
Int J Pept Res Ther, 13 (1-2), 53-68 (2007)

Analysis of interaction between dendriplexes and bovine serum albumin
Shcharbin D, Pedziwiatr E, Chonco L, Bermejo-Martín JF, Ortega P, de la Mata FJ, Eritja R, Gómez R, Klajnert B, Bryszewska M and Muñoz-Fernandez MA
Biomacromolecules, 8 (7), 2059-2062 (2007)

ds-Oligonucleotide-peptide conjugates featuring peptides from the leucine-zipper region of Fos as switchable receptors for the oncoprotein Jun
Portela C, Albericio F, Eritja R, Castedo L and Mascareñas JL
ChemBiochem, 8 (10), 1110-1114 (2007)

Solution equilibria of the i-motif-forming region upstream of the B-cell lymphoma-2 P1 promoter
Khan N, Aviñó A, Tauler R, González C, Eritja R and Gargallo R
Biochemie, 89 (12), 1562-1572 (2007)

Triplex formation using oligonucleotide clamps carrying 8-aminopurines
Aviñó A, Grimau MG, Alvira M, Eritja R, Gargallo R, Orozco M and González C
Nucleosides Nucleotides Nucleic Acids, 26 (8-9), 979-983 (2007)

A flexible method for the fabrication of gold nanostructures using oligonucleotide derivatives
Eritja R, Aviñó A, de la Torre BG, Fitzmaurice D, Ongaro A, Stanca SE, DiSalvo A, Maninng B and Iacopino D
Nucleosides Nucleotides Nucleic Acids, 26 (10-12), 1605-1609 (2007)

Water-soluble carbosilane dendrimers protect phosphorothioate oligonucleotides from binding to serum proteins
Chonco L, Bermejo-Martín JF, Ortega P, Shcharbin D, Pedziwiatr E, Klajnert B, de la Mata FJ, Eritja R, Gómez R, Bryszewska M and Muñoz-Fernandez MA
Org Biomol Chem, 5 (12), 1886-1893 (2007)

Water-soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications
Bermejo JF, Ortega P, Chonco L, Eritja R, Samaniego R, Müllner M, de Jesus E, de la Mata FJ, Flores JC, Gomez R and Muñoz-Fernandez A
Chemistry, 13 (2), 483-495 (2007)

Spectroscopic study of the interaction of actinomycin D with oligonucleotides carrying the central base sequences -XGCY- and -XGGCCY- using multivariate methods
Vives M, Tauler R, Eritja R and Gargallo R
Anal Bioanal Chem, 387 (1), 311-320 (2007)

New developments on the synthesis of oligonucleotide-peptide conjugates
Portela C, Mascareñas JL, Albericio F, Mazzini S, Caminal C, Ramos R, Ocampo SM and Eritja R
Nucleosides Nucleotides Nucleic Acids, 26 (8-9), 963-967 (2007)

Synthesis of oligonucleotides carrying 5’-5’ linkages using copper-catalyzed cycloaddition reactions
Alvira M and Eritja R
Chem Biodivers, 4 (12), 2798-2809 (2007)

Traightforward access to simplified sphingosine-1-phosphate analogues
Grijalvo S, Llebaria A and Delgado A
Synthetic Comm, 37, 2737-2751 (2007)

Solid-phase synthesis of a combinatorial library of dehydroceramide analogues and its activity in human alveolar epithelial cells
Villorbina G, Canals D, Carde L, Grijalvo S, Pascual R, Rabal O, Teixidó J, Fabriàs G, Llebaria A, Casas J and Delgado A
Bioorg Med Chem, 15 (1), 50-62 (2007)

A simple DNA-based traslation system
Garibotti AV, Liao S and Seeman NC
Nano Lett, 7 (2), 480-483 (2007)

Efficient sequence-specific purification of Listeria innocua mRNA species by triplex affinity capture with parallel tail-clamps
Nadal A, Coll A, Aviñó A, Esteve T, Eritja R and Pla M
Chembiochem, 7 (7), 1039-1047 (2006)

Resolution of a structural competition involving dimeric G-quadruplex and its C-rich complementary strand
Jaumot J, Eritja R, Tauler R and Gargallo R
Nucleic Acids Res, 34 (1), 206-216 (2006)

Destabilization of quadruplex DNA by 8-aminoguanine
López de la Osa J, González C, Gargallo R, Rueda M, Cubero E, Orozco M, Aviñó A and Eritja R
Chembiochem, 7 (1), 46-48 (2006)

Comparative uptake of phosphorothioate oligonucleotides by human peripheral blood mononuclear cells from newborns and adults
Bermejo JF, Chonco L, Samaniego R, Fernández G, Eritja R and Muñoz-Fernández MA
Eur J Sci Res, 15, 113-121 (2006)

DNA-templated assembly of nanoscale architectures for next-generation electronic devices
Stanca SE, Eritja R and Fitzmaurice D
Faraday Discuss, 131, 155-165 (2006)

Trimethylguanosine nucleoside inhibits cross-linking between Snurportin 1 and m3G-CAPPED U1 snRNA
Bahia D, Aviñó A, Darzynkiewicz E, Eritja R and Bach-Elias M
Nucleosides Nucleotides Nucleic Acids, 25 (8), 909-923 (2006)

DNA-templated assembly of nanoscale architectures
Stanca SE, Eritja R and Fitzmaurice D
Nanotechnology, 16 (9), 1905-1911 (2005)

A straightforward synthesis of 5'-peptide oligonucleotide conjugates using N(alpha)-Fmoc-protected amino acids
Ocampo SM, Albericio F, Fernández I, Vilaseca M and Eritja R
Org Lett, 7 (20), 4349-4352 (2005)

Magnetically trigged direct electrochemical detection of DNA hybridization using Au67 quantum dot as electrical tracer
Pumera M, Castañeda MT, Pividori MI, Eritja R, Merkoçi A and Alegret S
Langmuir, 21 (21), 9625-9629 (2005)

Toward an ICPMS-linked DNA assay based on gold nanoparticles immunoconnected through peptide sequences
Merkoçi A, Aldavert M, Tarrasón G, Eritja R and Alegret S
Anal Chem, 77 (19), 6500-6503 (2005)

"Parallel" and "antiparallel tail-clamps" increase the efficiency of triplex formation with structured DNA and RNA targets
Nadal A, Eritja R, Esteve T and Pla M
Chembiochem, 6 (6), 1034-1042 (2005)

Synthesis and triplex-forming properties of cyclic oligonucleotides with (G,A)-antiparallel strands
Grimau MG, Gargallo R, Aviñó A and Eritja R
Chem Biodivers, 2 (2), 275-285 (2005)

Strand displacement of double-stranded DNA by triples-forming antiparallel purine-hairpins
Coma S, Noé V, Eritja R and Ciudad CJ
Oligonucleotides, 15 (4), 269-283 (2005)

Synthesis of oligonucleotide-peptide conjugates carrying the c-myc peptide epitope as recognition system
Frieden M, Aviñó A, Tarrasón G, Escorihuela M, Piulats J and Eritja R
Chem Biodivers, 1 (6), 930-938 (2004)

Synthesis, stability, and protonation studies of a self-complementary dodecamer containing the modified nucleoside 2'-deoxyzebularine
Vives M, Eritja R, Tauler R, Marquez VE and Gargallo R
Biopolymers, 73 (1), 27-43 (2004)

Monitoring denaturation behaviour and comparative stability of DNA triple helices using oligonucleotide-gold nanoparticle conjugates
Murphy D, Eritja R and Redmond G
Nucleic Acids Res, 32 (7), e65 (2004)

Hybridization and melting behaviour of peptide nucleic acid-oligonucleotide chimeras conjugated to gold nanoparticles
Murphy D, Redmond G, De la Torre BG and Eritja R
Helv Chim Acta, 87, 2727-2734 (2004)

DNA templated assembly of a protein-functionalized nanogap electrode
Ongaro A, Griffin F, Nagle L, Iacopino D, Eritja R and Fitzmaurice D
Adv Materials, 16, 1799-1803 (2004)

Synthesis and triple-helix stabilization properties of branched oligonucleotides carrying 8-aminoadenine moieties
Aviñó A, Grimau MG, Frieden M and Eritja R
Helv Chim Acta, 87, 303-316 (2004)

Resolution of parallel and antiparallel oligonucleotide triple helices formation and melting processes by multivariate curve resolution
Jaumot J, Eritja R, Aviñó A, Tauler R and Gargallo RJ
Biomol Struct Dyn, 21 (2), 267-278 (2003)

Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain
Marquez VE, Eritja R, Kelley JA, Vanbemmel D and Christman JK
Ann N Y Acad Sci, 1002, 154-164 (2003)

Antiparallel triple helices. Structural characteristics and stabilization by 8-amino derivatives
Aviñó A, Cubero E, González C, Eritja R and Orozco M
J Am Chem Soc, 125 (51), 13127-16138 (2003)

Synthesis of branched oligonucleotides as templates for the assembly of nanomaterial
Grimau MG, Iacopino D, Aviñó A, De la Torre BG, Ongaro A, Fitzmaurice D, Wessels J and Eritja R
Helv Chim Acta, 86 (8), 2814-2826 (2003)

Peptide-PNA conjugates: targeted transport of antisense therapeutics into tumors
Mier W, Eritja R, Mohammed A, Haberkorn U and Eisenhut M
Angew Chem Int Ed Engl, 42 (17), 1968-1971 (2003)

Imaging the DNA and nanoparticle components of a self-assembled nanoscale architecture
Iacopino D, Ongaro A, Nagle L, Eritja R and Fitzmaurice D
Nanotechnology, 14 (4), 447-452 (2003)

DNA-controlled assembly of protein-modified gold nanocrystals
Cobbe S, Connolly S, Nagle L, Eritja R, Fitzmaurice D and Ryan D
J Phys Chem B, 107 (2), 470-477 (2003)

Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides.
Costa M, Solà M, del Solar G, Eritja R, Hernández-Arriaga AM, Espinosa M, Gomis-Rüth FX, Coll M.
J Mol Biol., 310 (2), 403-417 (2001)

Nucleic acid chemistry

Ramón Eritja
Group Leader
Professor (IQAC-CSIC)

Office Tel : +34 93 40 39942
Lab Tel : +34 93 403 99 42
e-mail : ramon.eritjairbbarcelona.org

Research Associates
Anna Maria Aviñó
tel +34 93 40 39941
e-mail: anna.avinyoirbbarcelona.org

Maria Carme Fàbrega
tel +34 93 40 39941
e-mail: carme.fabregairbbarcelona.org

Postdoctoral Fellows
Isaac Gallego
tel +34 93 40 39941
e-mail: isaac.gallegoirbbarcelona.org

Montserrat Terrazas
tel +34 93 40 39941
e-mail: montserrat.terrazasirbbarcelona.org

Sandra Milena Ocampo
tel +34 93 40 39941
e-mail: sandra.ocampoirbbarcelona.org

Santiago Grijalvo
tel +34 93 40 39941
e-mail: santiago.grijalvoirbbarcelona.org

Sonia Pérez
tel +34 93 40 39941
e-mail: sonia.perezirbbarcelona.org

PhD Students
Adele Alagia
tel +34 93 40 39941
e-mail: adele.alagiairbbarcelona.org

Maria Tintoré
tel +34 93 40 39941
e-mail: maria.tintoreirbbarcelona.org

Ruben Ferreira
tel +34 93 40 39941
e-mail: ruben.ferreirairbbarcelona.org

Nucleic acid chemistry

• 13 July 2011
  Institute News
  Nanoparticles against cancer
  

  Researchers at IRB Barcelona participate in the European project MultiFun, which seeks to study new diagnostic tools and treatments for cancer.

• 17 May 2010
  Público
  Nano-robots for a perfect world
  
• 1 February 2007
  Boletí­n Fundación BBVA
  El ARN de interferencia puede ser clave para el tratamiento de tumores
  
• 14 December 2006
  Diario Médico
  Diferentes formas de ARN desempeñan una función clave en la regulación genética
  

  The RNAi conference organized by IRB Barcelona in Diario Médico

• 11 December 2006
  Conference
  RNAi: BASIC BIOLOGY TO CLINICAL IMPACT
  

  Barcelona, SPAIN. 11 - 13 DECEMBER, 2006
  A BBVA Foundation and IRB Barcelona conference that will focus on the rapidly growing field of RNAi and non-coding RNAs

• 28 November 2006
  Feature Article
  RNA: much more than a simple messenger for DNA
  

  Ramon Eritja. Institute for Research in Biomedicine (IRB Barcelona)/CSIC Research Professor.
  Co-organizer of the conference “RNAi: basic biology to clinical impact”.