Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E and Ventura S.

P Natl Acad Sci Usa, 115 (41), 10481-1048 (2018)

Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport

Dıaz-Perlas C, Oller-Salvia B, Sanchez-Navarro M, Teixidó M, Giralt E.

Chem Sci, (2018)

Anti-EGF nanobodies block EGFR activation via two distinct molecular recognition mechanisms

Guardiola S, Varese M, Sánchez-Navarro M, Vincke C, Teixido M, Garcia J, Muyldermans S and Giralt E.

Angew Chem Int Edit, 15 13843-1384 (2018)

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics

Guardiola S, Prades R, Mendieta L, Brouwer AJ, Streefkerk J, Nevola L, Tarragó T, Liskamp RMJ and Giralt E.

Cell Chemical Biology, 25 (8), 1031-1037. (2018)

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics

Guardiola S, Prades R, Mendieta L, Brouwer AJ, Streefkerk J, Nevola L, Tarragó T, Liskamp RMJ and Giralt E.

Cell Chemical Biology, (2018)

Combating virulence of Gram-negative bacilli by OmpA inhibition

Vila-Farrés X, Parra-Millán R, Sánchez-Encinales V, Varese M, Ayerbe-Algaba R, Bayó N, Guardiola S, Pachón-Ibáñez ME, Kotev M, García J, Teixidó M, Vila J, Pachón J, Giralt E and Smani Y.

Sci Rep, 7 (1), 14683 (2017)

Jumping Hurdles: Peptides Able To Overcome Biological Barriers

Sánchez-Navarro M, Teixidó M and Giralt E.

Accounts Chem Res, 50 (8), 1847-1854 (2017)

Cytosolic delivery: Just passing through

Sánchez-Navarro M, Teixidó M and Giralt E.

Nat Chem, 9 (8), 727-728 (2017)

Blood-brain barrier peptide shuttles

Sánchez-Navarro M, Giralt E and Teixidó M.

Curr Opin Chem Biol, 38 134-140 (2017)

Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery

Oller-Salvia B, Sánchez-Navarro M, Giralt E and Teixidó M.

Chem Soc Rev, 45 (17), 4690-707 (2016)

MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery

Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.

Angew Chem Int Edit, 55 (2), 572-5 (2016)

Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles

Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M and Giralt E.

J Am Chem Soc, 137 (23), 7357-64 (2015)

Applying the retro-enantio approach to obtain a Peptide capable of overcoming the blood-brain barrier

Prades R, Oller-Salvia B, Schwarzmaier SM, Selva J, Moros M, Balbi M, Grazú V, de La Fuente JM, Egea G, Plesnila N, Teixidó M and Giralt E.

Angew Chem Int Edit, 54 (13), 3967-72 (2015)

Modulating protein-protein interactions: the potential of peptides

Nevola L and Giralt E.

Chem Commun, 51 3302-3315 (2015)

Absence of a stable secondary structure is not a limitation for photoswitchable inhibitors of β-arrestin/β-Adaptin 2 protein-protein interaction

Martín-Quirós A, Nevola L, Eckelt K, Madurga S, Gorostiza P and Giralt E.

Chem Biol, 22 (1), 31-7 (2015)

Delivering wasp venom for cancer therapy.

Moreno M, Zurita E, Giralt E.

J Control Release, 182 13-21 (2014)

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease

Pujadas L, Rossi D, Andrés R, Teixeira CM, Serra-Vidal B, Parcerisas A, Maldonado R, Giralt E, Carulla N and Soriano E.

Nat Commun, 5 3443 (2014)

Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death

Serra-Vidal B, Pujadas L, Rossi D, Soriano E, Madurga S and Carulla N.

Acs Chem Biol, 9 (11), 2678-85 (2014)

From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog

Oller-Salvia B, Teixidó M and Giralt E.

Biopolymers, 100 (6), 675-86 (2013)

Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis

Nevola L, Martín-Quirós A, Eckelt K, Camarero N, Tosi S, Llobet A, Giralt E and Gorostiza P.

Angew Chem Int Edit, 52 (30), 7704-8 (2013)

Shuttle-Mediated Drug Delivery to the Brain

Malakoutikhah M, Teixidó M and Giralt E.

Angew Chem Int Edit, 50 7998-8014 (2011)

Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E)

Martín I, Teixidó M and Giralt E.

Chembiochem, 12 (6), 896-903 (2011)

Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties

Sánchez L, Madurga S, Pukala T, Vilaseca M, López-Iglesias C, Robinson CV, Giralt E and Carulla N.

J Am Chem Soc, 133 (17), 6505-8 (2011)

Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange

Carulla N, Zhou M, Giralt E, Robinson CV and Dobson CM.

Accounts Chem Res, 43 (8), 1072-9 (2010)

Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand

Gordo S, Martos V, Santos E, Menéndez M, Bo C, Giralt E and de Mendoza J.

P Natl Acad Sci Usa, 105 (43), 16426-31 (2008)

Redesign of protein domains using one-bead-one compound combinatorial chemistry

Pastor JJ, Granados G, Carulla N, Rabanal F and Giralt E

J Am Chem Soc, 129 14922-32 (2007)

Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide

Pujals S, Fernandez-Carneado J, Kogan M, Martinez J, Cavelier F and Giralt E

J Am Chem Soc, 128 8479-83 (2006)