Cellular Plasticity and Disease publications

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R.M., Chondronasiou, D., Rovira, M., Fernández-Marcos, P.J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., Gómez-López, G., de Martino, A., Blasco, M.A., Abad, M. and Serrano, M.
Science, 6315 (354), -pii: aaf4445 (2016)
Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys
Ortega-Molina, A., Lopez-Guadamillas, E., Mattison, J.A., Mitchell, S.J., Muñoz-Martin, M., Iglesias, G., Gutierrez, V.M., Vaughan, K.L., Szarowicz, M.D., González- García, I., López, M., Cebrián, D., Martinez, S., Pastor, J., de Cabo, R. and Serrano, M.
Cell Metab. (21), 570-558 (2015)
Programmed cellular senescence during embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M. and Serrano, M.
Cell, 1104 (21), -1118 (2013)
Reprogramming in vivo produces teratomas and iPS cells with totipotency features
Abad, M., Mosteiro, L., Pantoja, C., Cañamero, M., Rayon, T., Ors, I., Graña, O., Megías, D., Domínguez, O., Martínez, D., Manzanares, M., Ortega, S. and Serrano, M.
Nature (502), 345-340 (2013)
Pten positively regulates brown adipose function, energy expenditure and longevity
Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gomez, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., Gonzalez-Barroso, M.M., Rial, E., Valverde, A.M., Bischoff, J.R. and Serrano, M.
Cell Metab. (15), 394-382 (2012)
P27Kip1 directly represses Sox2 during embryonic stem cell differentiation
Li, H., Collado, M., Villasante, A., Matheu, A., Lynch, C.J., Cañamero, M., Rizzoti, K., Carneiro, C., Martínez, G., Vidal, A., Lovell-Badge, R. and Serrano, M.
Cell Stem Cell (7), 852-845 (2012)
The Ink4/Arf locus is a barrier for iPS reprogramming
Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M.A. and Serrano, M.
Nature (460), 1139-1136 (2009)