The Molecular Medicine Programme includes diverse biomedical researchers with extensive technical skills and overlapping scientific interests. It seeks to further the knowledge of the molecular mechanisms that underlie physiological processes and their associated diseases and conversely to use insights from alterations in human diseases to solve fundamental biological problems. As a logical consequence, one of the primary goals of the Programme is the development of translational research and the creation of an active interface between the member research groups and clinical researchers.
The activities undertaken include innovative approaches to the study of the molecular bases of diseases, such as diabetes, metabolic syndrome, neurodegenerative diseases, obesity, inflammation, and aminoacidurias, and research into new therapeutic approaches or the generation of diagnostic tools for these diseases. In order to address the scientific challenges posed, programme members study the signal transduction pathways that control cellular processes, the regulatory mechanisms of the protein synthesis machinery, functional genomics, glycogen and mitochondrial metabolism, the molecular bases of inherited aminoacidurias and, among others, the structural bases of membrane transporter function.
MAIN RESEARCH THEMES:
- Molecular bases of metabolic and genetic diseases
- Translational control regulation and implications in disease
- Macrophage biology and inflammation
- Protein synthesis machinery and evolution