Publicacions de recerca | IRB Barcelona

Title

Year

Research Group

Senescence promotes invivo reprogramming through p16(INK4a) and IL-6

Mosteiro, Lluc; Pantoja, Cristina; de Martino, Alba; Serrano, Manuel

Aging Cell

e12711 -

2018

Targeting senescence

Serrano, Manuel; Barzilai, Nir

Nature Medicine

1092 -

1094

2018

AAVvector-mediated in vivo reprogramming into pluripotency

Senis, Elena; Mosteiro, Lluc; Wilkening, Stefan; Wiedtke, Ellen; Nowrouzi, Ali; Afzal, Saira; Fronza, Raffaele; Landerer, Henrik; Abad, Maria; Niopek, Dominik; Schmidt, Manfred; Serrano, Manuel; Grimm, Dirk

Nature Communications

2651 -

2018

Direct Evidence of the Presence of Cross-Linked A beta Dimers in the Brains of Alzheimer's Disease Patients

Vazquez de la Torre, Aurelio; Gay, Marina; Vilaprinyo-Pascual, Silvia; Mazzucato, Roberta; Serra-Batiste, Montserrat; Vilaseca, Marta; Carulla, Natalia

Analytical Chemistry

4552 -

4560

2018

Morphogenetic movements affect local tissue organisation during embryonic Drosophila morphogenesis

Letizia, Annalisa; Tosi, Sebastien; Llimargas, Marta

European Journal Of Cell Biology

243 -

256

2018

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

Claudia Salzer, Marion; Lafzi, Atefeh; Berenguer-Llergo, Antoni; Youssif, Catrin; Castellanos, Andres; Solanas, Guiomar; Oliveira Peixoto, Francisca; Stephan-Otto Attolini, Camille; Prats, Neus; Aguilera, Monica; Martin-Caballero, Juan; Heyn, Holger; Aznar Benitah, Salvador

Cell

175

1575 -

2018

Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst

Salomó E; Gallen A; Sciortino G; Ujaque G; Grabulosa A; Lledós A; Riera A; Verdaguer X

Journal Of The American Chemical Society

140

16967 -

16970

2018

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

Benhra N; Barrio L; Muzzopappa M; Milán M

Developmental Cell

161 -

2018

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes

Pich O; Muiños F; Sabarinathan R; Reyes-Salazar I; Gonzalez-Perez A; Lopez-Bigas N

Cell

175

1074 -

2018

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Bouchard J; Otero J; Scott D; Szulc E; Martin E; Sabri N; Granata D; Marzahn M; Lindorff-Larsen K; Salvatella X; Schulman B; Mittag T

Molecular Cell

19 -

2018

Centrobin is essential for c-tubule assembly and flagellum development in drosophila melanogaster spermatogenesis

Reina J; Gottardo M; Riparbelli M; Llamazares S; Callaini G; Gonzalez C

Journal Of Cell Biology

217

2365 -

2372

2018

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis

Youssif C; Cubillos-Rojas M; Comalada M; Llonch E; Perna C; Djouder N; Nebreda A

Embo Molecular Medicine

e8403 -

2018

TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β

Romero M; Sabaté-Pérez A; Francis VA; Castrillón-Rodriguez I; Díaz-Ramos Á; Sánchez-Feutrie M; Durán X; Palacín M; Moreno-Navarrete JM; Gustafson B; Hammarstedt A; Fernández-Real JM; Vendrell J; Smith U; Zorzano A

Nature Cell Biology

443 -

2018

Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

Campbell K; Lebreton G; Franch-Marro X; Casanova J

Plos Genetics

e1007167 -

2018

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism

Miret-Casals L; Sebastián D; Brea J; Rico-Leo E; Palacín M; Fernández-Salguero P; Loza M; Albericio F; Zorzano A

Cell Chemical Biology

268 -

2018

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Duch A; Canal B; Barroso S; García-Rubio M; Seisenbacher G; Aguilera A; De Nadal E; Posas F

Nature Communications

379 -

2018

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

De Mol E; Szulc E; Di Sanza C; Martínez-Cristóbal P; Bertoncini C; Fenwick R; Frigolé-Vivas M; Masín M; Hunter I; Buzón V; Brun-Heath I; García J; De Fabritiis G; Estébanez-Perpiñá E; McEwan I; Nebreda Á; Salvatella X

Structure

145 -

2018

Microtubule-Organizing Centers: Towards a Minimal Parts List

Paz J; Lüders J

Trends In Cell Biology

176 -

187

2018

Adherens Junction Length during Tissue Contraction Is Controlled by the Mechanosensitive Activity of Actomyosin and Junctional Recycling

Sumi, Angughali; Hayes, Peran; D'Angelo, Arturo; Colombelli, Julien; Salbreux, Guillaume; Dierkes, Kai; Solon, Jerome

Developmental Cell

453 -

2018

Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines

Cabré A, Sciortino G, Ujaque G, Verdaguer X, Lledós A, Riera A

Organic Letters

5747 -

5751

2018

A versatile drug delivery system targeting senescent cells

Muñoz-Espín D; Rovira M; Galiana I; Giménez C; Lozano-Torres B; Paez-Ribes M; Llanos S; Chaib S; Muñoz-Martín M; Ucero AC; Garaulet G; Mulero F; Dann SG; VanArsdale T; Shields DJ; Bernardos A; Murguía JR; Martínez-Máñez R; Serrano M

Embo Molecular Medicine

e9355 -

2018

Total Synthesis of ( R)-Sarkomycin Methyl Ester via Regioselective Intermolecular Pauson-Khand Reaction and Iridium-Catalyzed Asymmetric Isomerization.

Cabré A, Khaizourane H, Garçon M, Verdaguer X, Riera A

Organic Letters

3953 -

3957

2018

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A; Anta H; Santos-Galindo M; Swarup V; Elorza A; Nieto-González J; Picó S; Hernández I; Díaz-Hernández J; Belloc E; Rodolosse A; Parikshak N; Peñagarikano O; Fernández-Chacón R; Irimia M; Navarro P; Geschwind D; Méndez R*; Lucas J*

Nature

560

7719

441 -

2018

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E

Nature

554

7693

538 -

2018

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Freixo, Francisco; Delgado, Paula Martinez; Manso, Yasmina; Sanchez-Huertas, Carlos; Lacasa, Cristina; Soriano, Eduardo; Roig, Joan; Lueders, Jens

Nature Communications

2330 -

2018

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cánovas B; Igea A; Sartori A; Gomis R; Paull T; Isoda M; Pérez-Montoyo H; Serra V; González-Suárez E; Stracker T; Nebreda A

Cancer Cell

1094 -

2018

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Lynch, Cian J; Bernad, Raquel; Calvo, Isabel; Nobrega-Pereira, Sandrina; Ruiz, Sergio; Ibarz, Nuria; Martinez-Val, Ana; Grana-Castro, Osvaldo; Gomez-Lopez, Gonzalo; Andres-Leon, Eduardo; Angarica, Vladimir Espinosa; del Sol, Antonio; Ortega, Sagrario; Fernandez-Capetillo, Oscar; Rojo, Enrique; Munoz, Javier; Serrano, Manuel

Cell Reports

396 -

410

2018

Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids.

Vilches C, Boiadjieva-Knöpfel E, Bodoy S, Camargo S, López de Heredia M, Prat E, Ormazabal A, Artuch R, Zorzano A, Verrey F, Nunes V, Palacín M

Journal Of The American Society Of Nephrology

1624 -

1635

2018

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

Tamborero D; Rubio-Perez C; Deu-Pons J; Schroeder M; Vivancos A; Rovira A; Tusquets I; Albanell J; Rodon J; Tabernero J; de Torres C; Dienstmann R; Gonzalez-Perez A; Lopez-Bigas N

Genome Medicine

25 -

2018

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.

Espino Guarch M, Font-Llitjós M, Murillo-Cuesta S, Errasti-Murugarren E, Celaya AM, Girotto G, Vuckovic D, Mezzavilla M, Vilches C, Bodoy S, Sahún I, González L, Prat E, Zorzano A, Dierssen M, Varela-Nieto I, Gasparini P, Palacín M, Nunes V

Elife

e31511

e31511 -

2018

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+breast cancer

Gawrzak S; Rinaldi L; Gregorio S; Arenas EJ; Salvador F; Urosevic J; Figueras-Puig C; Rojo F; Del Barco Barrantes I; Cejalvo JM; Palafox M; Guiu M; Berenguer-Llergo A; Symeonidi A; Bellmunt A; Kalafatovic D; Arnal-Estapé A; Fernández E; Müllauer B; Groeneveld R; Slobodnyuk K; Stephan-Otto Attolini C; Saura C; Arribas J; Cortes J; Rovira A; Muñoz M; Lluch A; Serra V; Albanell J; Prat A; Nebreda AR; Benitah SA; Gomis RR

Nature Cell Biology

211 -

2018

Ablation of the stress protease OMA1 protects against heart failure in mice

Acin-Perez R; Lechuga-Vieco AV

Sci. Transl

2018

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

Finley LWS*, Vardhana SA*, Carey BW*, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, et al, [corr author] Thompson CB.
(*) these authors contributed equally

Nature Cell Biology

2018

Arid1a restrains Kras-dependent changes in acinar cell identity

Livshits D, Alonso-Curbelo D, Morris JP4th, Koche R, Saborowski M, Wilkinson JE, Lowe SW

eLife

2018

ERF deletion rescues RAS deficiency in mouse ES cells

Mayor-Ruiz C., Olbrich T., Drosten M., Lecona E., Vega-Sendino M., Ortega S., Dominguez O., Barbacid M., Ruiz S. & Fernandez-Capetillo O

Genes & Dev

568 -

576

2018

Clonal analysis of lineage fate in native haematopoiesis

Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo

Nature

2018

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind DH, Méndez R*, Lucas JJ*. (* co-corresponding authors).

Nature

560

7719

441 -

2018

The transcriptome of human oocytes is related to age and ovarian reserve

Barragán M; Pons J; Ferrer-Vaquer A; Cornet-Bartolomé D; Schweitzer A; Hubbard J; Auer H; Rodolosse A; Vassena R

Molecular Human Reproduction

535 -

548

2017

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Solanas G; Peixoto FO; Perdiguero E; Jardí M; Ruiz-Bonilla V; Datta D; Symeonidi A; Castellanos A; Welz PS; Caballero JM; Sassone-Corsi P; Muñoz-Cánoves P; Benitah SA

Cell

170

678 -

2017

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

Sato S; Solanas G; Peixoto FO; Bee L; Symeonidi A; Schmidt MS; Brenner C; Masri S; Benitah SA; Sassone-Corsi P

Cell

170

664 -

2017

Loss of dnmt3a and dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-g

Rinaldi L; Avgustinova A; Martín M; Datta D; Solanas G; Neus P; Benitah SA

Elife

e21697

e21697 -

2017

The dynamic assembly of distinct RNA polymerase i complexes modulates rDNA transcription

Torreira E; Louro J; Pazos I; González-Polo N; Gil-Carton D; Duran A; Tosi S; Gallego O; Calvo O; Fernández-Tornero C

Elife

e20832

e20832 -

2017

Tetraspanin 6: A pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Guix FX; Sannerud R; Berditchevski F; Arranz AM; Horré K; Snellinx A; Thathiah A; Saido T; Saito T; Rajesh S; Overduin M; Kumar-Singh S; Radaelli E; Corthout N; Colombelli J; Tosi S; Munck S; Salas IH; Annaert W; De Strooper B

Molecular Neurodegeneration

25 -

2017

Structure of the homodimeric androgen receptor ligand-binding domain

Nadal M; Prekovic S; Gallastegui N; Helsen C; Abella M; Zielinska K; Gay M; Vilaseca M; Taulès M; Houtsmuller A; Van Royen M; Claessens F; Fuentes-Prior P; Estébanez-Perpiñá E

Nature Communications

14388

14388 -

2017

Polarized cortical tension drives zebrafish epiboly movements

Hernández-Vega A; Marsal M; Pouille P; Tosi S; Colombelli J; Luque T; Navajas D; Pagonabarraga I; Martín-Blanco E

Embo Journal

25 -

2017

An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth

Rossi F; Molnar C; Hashiyama K; Heinen J; Pampalona J; Llamazares S; Reina J; Hashiyama T; Rai M; Pollarolo G; Fernández-Hernández I; Gonzalez C

Open Biology