IRB Barcelona is a self-standing, non-profit institution devoted to basic and applied biomedical research. It was set up in 2005 jointly by the Government of Catalonia and the University of Barcelona and is located at the Barcelona Science Park. The institute currently has more than 430 members (scientific, technical and administrative staff) from all over the world, who work across disciplines to advance research in the biomedical sciences.
IRB Barcelona seeks a PhD Student candidate to apply for the call of the Ministerio de Ciencia, Innovación y Universidades Ayudas para contratos predoctorales para la formación de doctores 2018, to be published in September 2019.
The successful candidate will work on the project The molecular basis of sex-linked malignant tumour dimorphism. (DROSOSEX). (Ref. PGC2018-097372-B-I00, PI Prof. Cayetano González).
The thesis will be directed by Prof. Cayetano González, PI of the Cell Division Laboratory.
In our laboratory we model cancer in flies to understand the cellular changes that drive malignant growth and to identify conserved mechanisms that might be relevant for human cancer therapy (Nat Rev Cancer, 2013). Over the last years we have made a number of significant contributions to this field. Recently we have shown that brain tumours that originate in l(3)mbt mutants larvae are strongly dimorphic, being more aggressive in males than in females. This tendency is in line with what is known for a wide range of human cancer types, for which the striking male predominance remains unexplained. We have found out that Drosophila experimental models of malignant growth may serve to investigate the cell biological axes that control sex-linked tumour dimorphism. We have identified potential regulators of sex-linked tumour dimorphism and showed that these genes may serve as targets to suppress sex-linked malignant traits. (Science Advances, 2019, accepted).
The proposed PhD project will extend this work, by analyzing a collection of validated Drosophila malignant brain neoplasms, with the aim of identifying those that may serve as models to investigate sex-linked dimorphism. This project will address the fundamental biological question of which are the molecular bases that account for tumours that are identical in origin, but present very different outcomes depending on the sex of the tumour bearer. Taking into account the high level of molecular conservation between most of the main molecular axes at work in animal cells, we expect that our findings in Drosophila models of neoplastic growth might help to understand sex-linked dimorphism in cancer.
Research in our laboratory is fundamentally multidisciplinary, combining the newest molecular biology and genetic analysis methods with biochemistry, genomics, proteomics, electron microscopy, and advanced light microscopy techniques.
Prof. C. González:
More info at: http://www.ciencia.gob.es/portal/site/MICINN/menuitem.dbc68b34d11ccbd5d52ffeb801432ea0/?vgnextoid=131955e2d5e01610VgnVCM1000001d04140aRCRD&vgnextchannel=115222e988f75610VgnVCM1000001d04140aRCRD (please note that since the 2019 call has been not published yet, the info available is 2018 call).
Please confirm your eligibility for this call before applying.