Barcelona BioMed Seminars

Identification of the critical p53 tumour suppression mechanisms in vivo

6 Oct 2016

Speaker: Ana Janic, PhD. The Walter and Eliza Hall Institute, Melbourne (Australia) and Member of the IRB Barcelona Alumni Network.

 

Organizer: IRB Barcelona

Date: Thursday, October 6, 12.00h

Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain

Host: Dr. Eduard Batlle, IRB Barcelona

Abstract

P53 is the most important gene in human cancer; despite this it remains unclear which of the process(es) activated transcriptionally by p53 are critical for its tumour suppressive function. Although apoptosis, cell cycle arrest and cell senescence have been implicated, total abrogation of these processes revealed that this is not the case, opening the question of which processes are in fact critical. We have resolved this using innovative sensitized shRNA/CRISPR library screens. Our findings demonstrate that:
(1) p53 is such a potent tumour suppressor precisely because it can activate so many diverse cellular responses that inhibit neoplastic transformation and expansion of nascent malignant cells, and, most excitingly
(2) that coordination of DNA repair constitutes the most important process activated by p53 for tumour suppression.
 

Oncology Programme Seminar