Nuclear Mechanogenomics & Early Disease Diagnosis
Speaker: Prof. G.V.Shivashankar. Mechanobiology Institute, National Universityof Singapore, Singapore & FIRC Institute of Molecular Oncology (IFOM), Milan, Italy.
Organizer: IRB Barcelona
Date: Monday, 26 June 2017, 15.00h
Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain
Host: Marco Milán, IRB Barcelona & Enrique Martin-Blanco, IBMB-CSIC
Extra-cellular micro-environmental signals are transduced to the nucleus to regulate diverse biological processes including cellular differentiation, development and homeostasis; but the underlying mechanisms are still unclear. Using a multidisciplinary approach combining high resolution optical imaging, quantitative single-cell biology, machine learning and functional genomics, our laboratory investigates the principles underlying the coupling between nuclear mechanics and genome regulation. I will describe our ongoing work that provides modular links between cellular geometry and nuclear mechanics and its impact on transcription dependent 3D organization of chromosomes and nuclear reprogramming. These modular links define the normal state of cells and are altered during diseases. Hence our studies also have profound impact on developing nuclear mechano-morphometric biomarkers for early disease diagnosis.
Cell and Developmental Biology Programme Seminar