Tuft cells: epithelial sentinels linking luminal danger to immune responses
Speaker: Philippe Jay, PhD. Montpellier Institute of Functional Genomics (IGF), CNRS-INSERM-University of Montpellier (France)
Organizer: IRB Barcelona
Date: Thursday, February 2, 12.00h
Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain
Host: Dr. Eduard Batlle, IRB Barcelona
Gut homeostasis relies on a tight regulation of inflammation according to luminal clues. Although the intestinal epithelium is in direct contact with the microbes, parasites and potentially allergenic, mutagenic and toxic compounds derived from our diet, little is known about the contribution of epithelial cells to instruct stroma-located immune cells and regulate their behaviour. We characterized the intestinal epithelial tuft cells, a neglected cell type of the mammalian intestinal epithelium, and demonstrated their essential role in initiating immune defence responses against helminth parasites. This constitutes the first known function for the intestinal tuft cells and represents an example of essential cooperation between epithelial and haematopoietic compartments to maintain tissue homeostasis.
Oncology Programme Seminar