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Yin Yang of coding and noncoding transcriptomes in healthy and diseased cells


Organizer: IRB BioMed Seminars

Speaker: Dr. Claudia Kutter  - Group Leader - Department of Microbiology, Tumor and Cell Biology, Karolinska Institute (MTC) - Science for Life Laboratory, Stockholm, Sweden

Date: Friday, 20 January 2023 at 12 PM

Place: Felix Serratosa Hall, PCB

Host: Lluis Ribas, PhD - Group Leader - Gene Translation Laboratory - IRB Barcelona - Aging and Metabolism Programme



The genetic code is an abstraction of how messenger RNA (mRNA) codons and transfer RNA (tRNA) anticodons molecularly interact during protein synthesis; indeed, the decoding of mRNAs by tRNAs forms the backbone of the central dogma. How the cell ensures optimal protein translation during organ development, species evolution and disease progression remains an area of intense investigation. To study cellular economics, they investigate the regulatory control and dependencies of codons and anticodons in mammalian cells across different cellular conditions. By using various sequencing methods, they quantify mammalian mRNAs and tRNAs gene expression changes in healthy and diseased cells. Their work revealed that codon and anticodon pools are overall stable to tightly regulate amino acid supply and demand across vastly heterogenous cell type transcriptomes. However, there are exceptions, which can explain the underlying molecular basis of disorders. Given that translational control is critical for maintaining cellular homeostasis, their approach can be exploited to accurately predict physiological and pathological cell stages. If time permits, she will elaborate on perks and nuisances when using CRISPR/Cas9 approaches to study gene functionality.


IRB BioMed Seminars

IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.