A study published in Nature Communications and led by Maria J Macias highlight new DNA motifs for the Smads proteins.
The PhD4MD Programme allows medical doctors to do a three-year research project devoted to cancer or to respiratory or neurodegenerative diseases.
There are currently eight medical doctors conducting research in centres of excellence in Barcelona, and this year this number may increase by up to four more.
A team of scientists headed by Roger Gomis at IRB Barcelona reveals one of the mechanisms that allows metastatic cells to leave a latent state.
It is a factor that has been conserved through evolution, from plants to mammals
RPAP1 regulates the activity of RNA polymerase II by means of its interaction with gene transactivators
A team headed by Antonio Zorzano at IRB Barcelona has identified activators of the mitochondrial protein Mitofusin 2 for the treatment of type 2 diabetes.
The protein is a key regulator of many mitochondrial functions, as well as of the cell as a whole.
GenStorm (“An integrated approach to visualize and model the spatial conformation of genes at the nanoscale level”), led by Pablo Daniel Dans (IRB Barcelona) and Marie Victoire Neguembor (CRG) is one of this projects.
Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.
This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.
The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
The programme seeks to stir young people’s interest in science by allowing them to get involved in real projects.
"Crazy About Biomedicine" is part of an initiative run by the Fundación Catalunya - La Pedrera.
The Ferrer Research Foundation acknowledges the various perspectives of his research into cancer and aging.
Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.
The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.
Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.