Fran Supek (IRB Barcelona) and Ben Lehner (CRG) identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors.
Many mutations in human cancers are caused by mistakes made by a repair mechanism or ‘DNA spellchecker’ rather than the actual damage to DNA caused by the environment.
Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.
Scientists at IRB Barcelona identify a key component of the machinery that allows Staphylococcus aureus to transfer genes that confer antibiotic resistance.
Infection by antibiotic-resistant S. aureus is a serious threat in hospitals worldwide.
Halting the spread of antibiotic-resistant bacteria is one of the strategies available to tackle hospital infections.
Gonzalo Fernández-Miranda, associate researcher at IRB Barcelona, leads this therapeutic project selected by CaixaImpulse to facilitate its development towards the market.
Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.
These findings will help researchers to better understand pathological processes such as cancer.
The work is the first to report on the key role of the TLK2 gene in mouse embryo development.
The study solidifies an important role for both TLK1 and TLK2 in genome stability.
A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.
IRB Barcelona is to participate in the two-week (10-21 July) scientific summer camp through the project “Drosophila melanogaster: a model to study human disease”.
This initiative is organised by the Catalunya-La Pedrera Foundation, in collaboration with first-class research centres all over Catalonia, including BIST centres.
A study published in Cell Metabolism by IRB Barcelona scientists turns long-standing assumptions about glycogen biology on their head.
The results may explain the muscular defects of patients with glycogen storage disease XV.
Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster.
Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process.
Understanding the development of limbs in Drosophila paves the way to research into congenital defects in vertebrates.
At the BIST Board of Trustees meeting, which took place today in Barcelona, the incorporation of the Institute for Bioengineering of Catalonia (IBEC) as a new member of the Foundation was also approved.
Silberman, who holds a PhD in Computer Science and brings a lot of research experience in both the private and university sectors, will succeed Miquel A. Pericàs, who combined the position within the BIST with the direction of ICIQ.
IRB Barcelona, along with another 30 Catalan companies and organisations, is participating in the four-day convention in San Diego.
The BIO International Convention (BIO) is the top partnering fair for the biomedical sector.
The Institute’s spin-offs Iproteos and Nostrum Biodiscovery are also visiting the fair.