Human colon stem cells have been identified and grown in a lab plate for the first time. This achievement, made by researchers in the Colorectal Cancer Lab at the Institute for Research in Biomedicine (IRB Barcelona) and published in Nature Medicine, is a crucial advance towards regenerative medicine.
Using a mouse model, researchers at IRB Barcelona have demonstrated a link between abnormal sugar accumulation and the neuronal degeneration characteristic of Lafora disease. The study may contribute to understanding the origin and progression of Lafora and other neurodegenerative pathologies.
Researchers at IRB Barcelona discover a crucial mechanism controlling the segregation of genetic material from parent to daughter cells. A finely tuned process of degradation tightly regulates CenH3 protein levels to ensure the correct function of the cell division machinery in Drosophila.
The use of crystallography allows us to 'see' the regulation of gene expression in bacteria.
Researchers at IRB Barcelona describe the molecular mechanisms that define distinct territories in the intestinal epithelium.
These molecular mechanisms could be highly relevant in the development of malignant tumors.
Two quests, one looking into adhesion molecules to gain insight into compartmentalization in the Drosophila wing and the other aiming to discover how the cytoskeleton contributes to the development of compartment boundaries are now linked by a single microRNA, bentam.
These research results could revolutionize reproductive medicine and human stem cell studies.
The proteins p38α and p38β cooperate during embryo development. This finding suggests that they may also do so in other contexts such as cancer and cardiac diseases.
Today in the CosmoCaixa of Barcelona, the Social Programme of “La Caixa” has presented the 40 fellowships corresponding to the third edition of the “La Caixa” International PhD Programme, which seeks to attract talented young students to do a PhD in one of four selected reference centres in biomedicine in Spain, among these the Institute for Research in Biomedicine (IRB Barcelona). The other beneficiary centres are the “Centro Nacional de Biotecnología” (CNB-CSIC), the “Centro Nacional de Investigaciones Oncológicas Carlos III” (CNIO) and the “Centro de Regulación Genómica” (CRG).
The event was attended by the Minister of Science and Innovation, Cristina Garmendia, the Director...
Researchers at IRB Barcelona participate in the European project MultiFun, which seeks to study new diagnostic tools and treatments for cancer.