Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice.
The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia.
The team headed by Angel Rodríguez Nebreda, ICREA researcher at IRB, identifies for the first time in mice that the p38 MAPK protein is required for the survival and proliferation of colon cancer cells.
In the same study the scientists demonstrate that a p38 inhibitor that has been used in clinical trials for inflammatory diseases shrinks the tumours in mice.
The study, published today in Cancer Cell, has received funding from the BBVA Foundation, the European project InflaCare, the Spanish Government, and the European Research Council (ERC).
The study by Sofia J. Araújo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial.
The study describes the neuroprotective effect of reelin in neurodegenerative diseases.
Co-directed by Eduardo Soriano and Lluís Pujadas, from the University of Barcelona, and the CIBERNED network, the study has involved Bernat Serra-Vidal, Ernest Giralt and Natàlia Carulla, all three scientists at IRB.
Two articles produced by Joan Guinovart’s lab answer key questions regarding the activity of glycogen in neurons.
An excess of glycogen causes neuronal death while a lack of this polysaccharide endangers these cells under oxygen shortage to the brain.
E. coli is the best known model organism at the molecular level. It is used extensively for biotechnology production, and its infectious strains are of biomedical interest.
The article in Nature Biotecnology is a collaborative effort between biologists, biochemists and bioinformaticians at the Craig Venter Institute, the University of Virginia, and the Institute for Research in Biomedicine (IRB).
The team of 18 researchers presents the first map of key interactions between the molecular components of the bacteria, and allow us to understand how its most intimate machinery works.
DNA intercalators developed for use in chemotherapy interfere with the DNA of cancer cells, thus eliminating them.
Researchers at IRB, in collaboration with a team in Sweden, publish the study in Angewandte Chemie.
Researchers at IRB Barcelona, BSC, and the University of Bern observe the first structure of a human HAT at low resolution.
HAT amino acid transporters are involved in pathologies such as aminoacidurias, cancer, viral infections and cocaine addiction.
The breakthrough published in the Proceedings of the National Academy of Science USA allows researchers to delve into the functions of HATs and to address the rational drug design of inhibitors.
The study has been partially funded by the European project EDICT (European Drug Initiative on Channels and Transporters), devoted to increasing the number of membrane protein structures available.
Researchers at IRB and IBMB-CSIC, in Barcelona, and at the University of Wageningen, in the Netherlands, reveal how auxin hormone-regulated proteins activate developmental genes in plants.
Auxins are key components of plant growth and have many applications in agriculture. The biomedical application of these hormones are also being addressed.
The study is published this week in the scientific journal Cell.
This is a software application that provides easily interpretable maps from which to analyse and understand the immense volume of epigenetic and genetic data available.
The work is the fruit of collaboration between biostatisticians, biocomputational researchers and molecular biologist at IRB Barcelona. The capacity of ChroGPS is described in an article in Nucleic Acids Research.