When adenomas appear in the colon, the same cells of the tissue produce a molecule that neutralizes its progression.
Adenomas, which are highly prevalent in the population, provide the substrate on which carcinomas develop.
A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.
Roger Gomis’ team, in collaboration with another two groups in IRB Barcelona’s Oncology Programme, reveal in Nature Cell Biology the genes and mechanisms that allow liver metastasis to colonize the lung.
The breakthrough introduces a new concept of metastasis from metastasis, which may require a distinct clinical treatment to metastases generated from the primary tumour.
The study has been partially supported by the BBVA Foundation, which provides two IRB groups signing this article with structural funds.
The research headed by Roger Gomis at IRB Barcelona, with the collaboration of Joan Massagué, describes that the loss of the suppressor RARRES3 promotes the colonization of breast cancer cells in the lung.
RARRES3 could prove to be a useful marker to identify patients with a greater risk of metastasis, as well as providing a target for the development of a specific treatment for preventive strategies after removal of the primary tumour.
The study has received, among others, funding from the BBVA Foundation, which provides structural funds for the development of research addressing metastasis at IRB Barcelona.
Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice.
The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia.
The team headed by Angel Rodríguez Nebreda, ICREA researcher at IRB, identifies for the first time in mice that the p38 MAPK protein is required for the survival and proliferation of colon cancer cells.
In the same study the scientists demonstrate that a p38 inhibitor that has been used in clinical trials for inflammatory diseases shrinks the tumours in mice.
The study, published today in Cancer Cell, has received funding from the BBVA Foundation, the European project InflaCare, the Spanish Government, and the European Research Council (ERC).
The study by Sofia J. Araújo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial.
The study describes the neuroprotective effect of reelin in neurodegenerative diseases.
Co-directed by Eduardo Soriano and Lluís Pujadas, from the University of Barcelona, and the CIBERNED network, the study has involved Bernat Serra-Vidal, Ernest Giralt and Natàlia Carulla, all three scientists at IRB.
Two articles produced by Joan Guinovart’s lab answer key questions regarding the activity of glycogen in neurons.
An excess of glycogen causes neuronal death while a lack of this polysaccharide endangers these cells under oxygen shortage to the brain.
E. coli is the best known model organism at the molecular level. It is used extensively for biotechnology production, and its infectious strains are of biomedical interest.
The article in Nature Biotecnology is a collaborative effort between biologists, biochemists and bioinformaticians at the Craig Venter Institute, the University of Virginia, and the Institute for Research in Biomedicine (IRB).
The team of 18 researchers presents the first map of key interactions between the molecular components of the bacteria, and allow us to understand how its most intimate machinery works.