Noticias Científicas

<p>Researchers at IRB Barcelona and IBEC design the first peptides regulated by light to modulate biological processes @Laura Nevola</p>
18 Jun 2013

Researchers at IRB Barcelona and IBEC achieve photo-switchable molecules to control protein-protein interactions in a remote and non-invasive manner.

These tools will serve as a prototype to develop photo-switchable drugs, whose effects would be limited to a given region and time, thus reducing the side effects on other regions.

The article, cover and “Very Important Paper” of Angewandte Chemie, is a highlighted result of the European project “OpticalBullet”, funded by the European Research Council (ERC) and in which the two institutes participate.

<p>Different views of a DNA molecule ©3DMaps/IRB Barcelona/BSC-CNS</p>
13 Jun 2013

Researchers with the joint programme Institute for Research in Biomedicine (IRB Barcelona)- Barcelona Supercomputing Center (BSC) on Computational Biology, together with scientists at Center for Genomic Regulation (CRG) have discovered a hidden DNA structural code that provides novel insights on gene expression. The results are available in the electronic version of ...

7 Jun 2013

• Headed by EMBL in Germany, the consortium “SyStemAge” seeks to identify the molecular mechanisms behind aging and the consequences of this process, and also to propose biomarkers to combat age-related diseases.

• The consortium involves clinical researchers, biologists specialized in two types of blood cancer, systems biologists, and biotech managers.

Patrick Aloy, researcher at IRB Barcelona, will integrate the biological and clinical data to build dynamic maps of genes and proteins involved in the processes addressed in this study.

<p>ICREA researcher Eduard Batlle heads one of the work packages</p>
3 Jun 2013

Each year about 330,000 Europeans are diagnosed with colorectal cancer, a disease with a mortality rate of 44%. Many of the new treatments fail in clinical assays, and colorectal cancer metastasis is largely incurable

<p>Cover of the Cancer Cell Best of 2012</p>
14 May 2013

The journal Cancer Cell ranks the article on colon cancer metastasis by Eduard Batlle and Elena Sancho among the best 10 in 2012.

<p>Dr. Albericio's laboratory has synthesized Thiocoraline, a natural anti-cancer agent, shaped like a staple</p>
3 May 2013

A new technique from IRB Barcelona combines chemistry and biology to produce an exact copy of the natural molecule Thiocoraline.

Thiocoraline is a potent anti-cancer agent that is chemically very complex, isolated from a sea sponge in 1997 by the company PharmaMar.

19 Apr 2013

• This is the first study that studies and quantifies 1,600 known adverse effects of drugs currently on the market.

• The scientists Miquel Duran and Patrick Aloy provide a description of the molecular processes responsible for more than 1,000 secondary effects.

• This knowledge, which is available to the scientific community, may be of great use to minimize and predict adverse effects during drug design.

<p>Diagram of the protein unfolding in presence of urea. Author: M Candotti © IRB Barcelona</p>
26 Mar 2013

IRB Barcelona scientists pave the way towards describing the conformation of proteins that do not have a defined structure

Structural and theoretical techniques are combined to develop new methodologies for the analysis of proteins

<p>Binding of protein LC8 (yellow and orange) with a fragment of phoshorylated Nek 9, active form, (right) and non-phoshorylated form, inactive (left).</p>
25 Mar 2013

Joan Roig’s team collect three-dimensional information of protein complexes involved in cell division.

25 Mar 2013

Collaboration between researchers at the Institut de Biotecnologia i de Biomedicina (IBB) of the “Universitat Autònoma de Barcelona”, the Institute for Biocomputation and Physics of Complex Systems in Zaragoza, and IRB Barcelona has led to the publication of the first scientific paper on data collected from the BL13-XALOC beamline of the Alba Synchrotron, located in Cerdanyola de Vallès, a facility that which allows scientists to obtain 3D structures of macromolecular complexes.

The team at IRB Barcelona headed by the research associate Joan Roig...