Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster.
Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process.
Understanding the development of limbs in Drosophila paves the way to research into congenital defects in vertebrates.
A study co-led by IRB Barcelona and IDIBAPS emphasizes the importance of the neuronal mechanisms in the detection of nutrients and the control of glucose levels.
The results published in Cell Metabolism help to understand diabetes in greater detail.
Researchers led by Salvador Aznar-Benitah at IRB Barcelona investigate the role of Dnmt3a and Dnmt3b proteins in skin homeostasis and tumour development in adult mice.
The study has been published in eLife and deserved an eLife digest aimed at a more general audience.
In EMBO Molecular Medicine, IRB Barcelona scientists report a technique based on a combination of CRISPR/Cas9 genome editing and patient-derived tumour organoids that allows the study of cell heterogeneity in human tumours.
The novel approach was used to examine the behaviour of colorectal cancer stem cells by tracing specific marker genes.
p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions.
Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors.
These findings are the result of combining fundamental biological data using computational techniques.
Researchers at IDIBAPS and IRB Barcelona have described in Cancer Research, that the longer the time from the onset of the tumour to the development of metastasis is, the more aggressive this cancer becomes.
Researchers unveil a mechanism responsible for halting protein synthesis when cells are deprived of nutrients.
The cell regulates its growth by forming various assemblies of RNA polymerase I.
The study has implications for cancer research.
IDIBAPS and IRB Barcelona researchers show the effectiveness of a new strategy to achieved genetically modified viruses that infect only tumor cells, thus preserving healthy tissues.
It is an innovative approach that exploits the different expression profiles of certain proteins between tumor and healthy cells, thus allowing the virus to infect only the former.
These comprise a small group of passive stem cells—quiescent—that are activated when needed and have the capacity to produce any kind of intestinal cell.
Quiescent cells are relevant for tissue regeneration and for their participation in tumour development.
Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3D the protein machinery inside living cells
Published in the journal Cell, the study unveils key functional features of an assembly of proteins that is vital for animals and plants.
With this new strategy in hand, it will be possible to study cellular protein machinery in health and in disease.