A study performed at IRB Barcelona supports the notion that mitochondrial defects underlie a set of diseases of unknown origin that involve chronic muscle inflammation.
It seems the amino acid transporter SLC7A8/SLC3A2 plays an important role in this disease.
The study was coordinated by Manuel Palacín from IRB Barcelona and Virginia Nunes from IDIBELL.
In spite of the difference between the cell functions responsible for giving rise to a tumour and for the metastasis of this same tumour, studies at IRB Barcelona using the fly Drosophila melanogaster reveal that some genes can drive both phenomena.
A team headed by ICREA researcher Eduard Batlle discovers that immune system-stimulating treatments combined with a TGF-beta inhibitor are effective against colon cancer.
The researchers developed a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for the first time.
A study published in Nature Communications and led by Maria J Macias highlight new DNA motifs for the Smads proteins.
A team of scientists headed by Roger Gomis at IRB Barcelona reveals one of the mechanisms that allows metastatic cells to leave a latent state.
It is a factor that has been conserved through evolution, from plants to mammals
RPAP1 regulates the activity of RNA polymerase II by means of its interaction with gene transactivators
A team headed by Antonio Zorzano at IRB Barcelona has identified activators of the mitochondrial protein Mitofusin 2 for the treatment of type 2 diabetes.
The protein is a key regulator of many mitochondrial functions, as well as of the cell as a whole.
Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.
This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.
The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.
The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.
Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.