Noticias Científicas

<p>CPEB4 liquid-like droplets in the cell cytoplasm (J. Guillén-Boixet, IRB Barcelona)</p>
21 Nov 2016

A study at IRB Barcelona sheds light on the dynamics of protein aggregates that behave like “droplets of oil in water” and that are described as membraneless cytoplasmic organelles.

These organelles regulate protein activity during cell division.

This is the first study at the Institute to address the so-called liquid-like droplets, which are attracting the attention of researchers worldwide.

<p>Highly ramificated tracheal cell of a Drosophila larvae marked with GFP. (Delia Ricolo)</p>
29 Sep 2016

Researchers working with flies at IRB Barcelona describe that the concentration of some small intracellular organelles determines the branching capacity of tracheal cells.

Tracheal cells are analogous to the cells that form blood vessels in the human body. The inhibition or stimulation of new blood vessels has implications in cancer and in tissue regeneration.

<p>Organisation of the tracheal systems in Drosophila (A) and Tribolium (B)</p>
20 Sep 2016

Changes in the regulation of two genes explain how the Drosophila respiratory system evolved from a primitive to a more developed state

Published in Development

<p>Beta amyloid protein and AD are strongly linked but the role of this protein in this disease remains elusive. Hippocampus of transgenic mice overexpressing amyloid beta. In blue, neuronal nuclei. In green, beta amyloid plaques (E.Verdaguer/S.Brox)</p>
13 Sep 2016

Researchers at IRB Barcelona describe for the first time how to prepare a specific type of aggregate of the amyloid-beta protein with the ability to perforate the cell membrane.

What causes neuron death and the subsequent cognitive decline in Alzheimer´s disease is still unknown.

<p>Depicted above, (+)-ryanodol is a derivate of a natural compound with intracellular calcium-regulating capacity</p>
12 Sep 2016

The journal Science publishes a commentary article on the Pauson-Khand reaction made by an expert at IRB Barcelona

<p>Eadweard Muybridge's pictures of a galloping horse enabled detailed analysis of animals and humans in motion. Today's protein research is faced with a similar situation when trying to understand how proteins move. (L. Orellana)</p>
5 Sep 2016

Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.

They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.

<p>Shuttle peptides are molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system</p>
25 Aug 2016

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently.

IRB Barcelona is one of the few centres worldwide with a specific line of research devoted to this field, which brings together chemistry, pharmacy and biomedicine.

The article appears on the cover of the journal Chemical Society Reviews.

<p>Structure of the Androgen Receptor. NTD: N-terminal domain; DBD: DNA binding domain; LBD: Ligand binding domain. Numbers indicate the first and last aminoacids of the protein, and the domain limits.</p>
16 Aug 2016

The finding paves the way for the identification of new therapeutic targets for many diseases.

<p>Skin stem cells. In blue, a marker of the cell nucleus. In green, a marker for the Dnmt3a protein, which is critical to ensure that cells retain stem cell features (Lorenzo Rinaldi, IRB Barcelona)</p>
28 Jul 2016

Without these proteins, skin stem cells are lost.

The study headed by Salvador Aznar Benitah at IRB Barcelona has been published today in Cell Stem Cell.

<p>Microscopy image of a culture mouse neuron showing the microtubule network in green and red depending on chemical modifications. The axon, in bright green, is the neuronal extension that has the greatest number of modified microtubules (Author: Carlos Sán</p>
21 Jul 2016

The study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as Alzheimer’s.