Noticias Científicas

<p>Eadweard Muybridge's pictures of a galloping horse enabled detailed analysis of animals and humans in motion. Today's protein research is faced with a similar situation when trying to understand how proteins move. (L. Orellana)</p>
5 Sep 2016

Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.

They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.

<p>Shuttle peptides are molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system</p>
25 Aug 2016

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently.

IRB Barcelona is one of the few centres worldwide with a specific line of research devoted to this field, which brings together chemistry, pharmacy and biomedicine.

The article appears on the cover of the journal Chemical Society Reviews.

<p>Structure of the Androgen Receptor. NTD: N-terminal domain; DBD: DNA binding domain; LBD: Ligand binding domain. Numbers indicate the first and last aminoacids of the protein, and the domain limits.</p>
16 Aug 2016

The finding paves the way for the identification of new therapeutic targets for many diseases.

<p>Skin stem cells. In blue, a marker of the cell nucleus. In green, a marker for the Dnmt3a protein, which is critical to ensure that cells retain stem cell features (Lorenzo Rinaldi, IRB Barcelona)</p>
28 Jul 2016

Without these proteins, skin stem cells are lost.

The study headed by Salvador Aznar Benitah at IRB Barcelona has been published today in Cell Stem Cell.

<p>Microscopy image of a culture mouse neuron showing the microtubule network in green and red depending on chemical modifications. The axon, in bright green, is the neuronal extension that has the greatest number of modified microtubules (Author: Carlos Sán</p>
21 Jul 2016

The study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as Alzheimer’s.

<p>Scheme showing the relation between different levels of expression of Mitofusin 2 and muscle aging. (D. Sebastián, IRB Barcelona, CIBERDEM)</p>
22 Jun 2016

IRB Barcelona researchers discover that the loss of the protein Mitofusin 2 in the muscles of young mice speeds up aging and causes early sarcopenia, thus leading to the muscle quality of aged mice.

Sarcopenia, which is muscle wastage and the accompanied loss of strength, is one of the most weakening conditions of old age and it has no treatment.

The scientists propose that stimulating Mitofusin 2 activity would provide a good strategy through which to ameliorate sarcopenia.

<p>Protein Androgen Receptor forms aggregatesthat damage muscle and motor neuron cells in Kennedy's Disease (B. Eftekharzadeh, IRB Barcelona)</p>
10 Jun 2016

Kennedy’s disease leads to progressive muscle wastage. It is a condition that affects only men and it appears between 40 and 50 years of age. There is no specific treatment available.

In individuals with this disease, muscle cells and motor neurons die over the years because they accumulate a protein that is mutated.

Researchers at IRB Barcelona discover that this protein has a self-protective mechanism through which the deleterious effects of the mutation are delayed.

<p>3D respresentation of a transfer RNA (tRNA). These molecules are crucial for the translation of genes into proteins and they are also the reason why the genetic code cannot exceed 20 amino acid. (Author: Pablo Dans, IRB Barcelona)</p>
2 May 2016

A study performed at IRB Barcelona offers an explanation as to why the genetic code, the dictionary used by organisms to translate genes into protein, stopped growing 3,000 million years ago.

The reason is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins.

The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life.

The discovery could have applications in synthetic biology.

<p>Breast tumours have high levels of LIPG expression (F Slebe, IRB Barcelona)</p>
5 Apr 2016

In an article published in Nature Communications, scientists at IRB Barcelona reveal that breast cancer cells require fatty acids from the extracellular environment in order to continue proliferating.

<p>Microscopic structure of mouse testicle tissue (P.Mikolcevic, IRB Barcelona)</p>
30 Mar 2016

Scientists at IRB Barcelona discover a crucial protein for meiosis—the cell division process that gives rise to sex cells.

Without the RingoA protein, both male and female mice are sterile.

Published in Nature Communications, the results could pave the way for the development of male contraceptives.