The simulation method developed in Modesto Orozco’s laboratory allows the study—with unprecedented accuracy—of structural changes in DNA and of the interaction of DNA with proteins and drugs.
All the simulations and posterior analyses are kept in the first online tool developed to date dedicated to atomic level simulations of nucleic acids.
The platform is free of charge and available to the entire scientific community through the Spanish Institute of Bioinformatics and the European network ELIXIR-Excellerate.
In addition to other uses, the new method provides greater insight into how DNA is recognised by proteins that modify its function or by the drugs that bind to it to exert their therapeutic action, thereby furthering our understanding of the biological function of DNA.
Natàlia Carulla’s research group provides information that questions the widely accepted premise regarding the number of molecules and the shape of the first aggregates formed by amyloid beta protein
Amyloid beta protein aggregation, the process by which molecules of this protein adhere to each other is strongly associated with the development of Alzheimer’s disease
Carulla’s work ultimately seeks to identify molecules that interfere with the initial stages of aggregation as a strategy to combat the disease.
A study published today in the Journal of National Cancer Institute (JNCI) by ICREA researcher Roger Gomis may be key to the early detection of patients at risk of developing metastasis to the bone
This new knowledge may accelerate the development of the first preventive treatment of bone metastasis
Inbiomotion, an IRB Barcelona spin off company and financed with venture investors Ysios Capital, has already begun clinical trials
Scientists at IRB Barcelona publish the details of an old tissue transplant method for Drosophila melanogaster.
This technique allows the study of tumour growth and tissue regeneration
A study conducted in collaboration with the CSIC, BSC and UB provides a new approach to follow cellular proteins more closely.
The target proteins labelled with inntags do not show detectable alterations of function or localization.
Researchers at IRB Barcelona unravel a role for tumour suppressor genes in restricting the growth of neighbouring cell populations.
The study, published yesterday in PLoS Biology, might have implications for understanding the early events of tumorigenesis and the selection of the tumour-initiating cells.
The study, published in Current Biology, focuses on cilia, the cellular structures that by sensing chemicals and mechanical forces allow for smelling, hearing, and many other essential functions.
Researchers at IRB Barcelona reveal that the protein E-Cadherin is required for groups of diverse cells to migrate together
Tumours with intermediary levels of E-Cadherin generally have a poorer prognosis; the phenomenon of heterogeneous cell migration may be related to this
Researchers at IRB Barcelona discover the molecular mechanism that determines how epigenetic markers influence gene expression
Combination of two strong denaturants of DNA leads to stabilization of the structure
An unexpected finding that opens new fields to the biotechnological use of DNA