Noticias Científicas

15 Sep 2015

Scientists at IRB Barcelona publish the details of an old tissue transplant method for Drosophila melanogaster.

This technique allows the study of tumour growth and tissue regeneration

<p>Inntags is a new tool for protein tagging (Image: Dr Aldea's laboratory)</p>
1 Sep 2015

A study conducted in collaboration with the CSIC, BSC and UB provides a new approach to follow cellular proteins more closely.

The target proteins labelled with inntags do not show detectable alterations of function or localization.

<p>Depletion of the PTEN tumour suppressor gene induces tissue overgrowth and reduces the growth of the neighbouring cell population in Drosophila wing primordia (Image: Marco Milán’s Lab).</p>
28 Aug 2015

Researchers at IRB Barcelona unravel a role for tumour suppressor genes in restricting the growth of neighbouring cell populations.

The study, published yesterday in PLoS Biology, might have implications for understanding the early events of tumorigenesis and the selection of the tumour-initiating cells.

<p>The bristle is a mechano-sensory organ that houses the cilium projected by a neuron.  Two structures found at the base of each cilium, centriole, and transition zone, can be seen in green and red, respectively (Gonzalez Lab)</p>
21 Aug 2015

The study, published in Current Biology, focuses on cilia, the cellular structures that by sensing chemicals and mechanical forces allow for smelling, hearing, and many other essential functions. 

<p>In a developing Drosophila embryo, (above) E-Cadherin keep cells together to facilitate coordinated migration; (below) without E-Cad cells are disorganised. (J Casanova lab)</p>
14 Aug 2015

Researchers at IRB Barcelona reveal that the protein E-Cadherin is required for groups of diverse cells to migrate together

Tumours with intermediary levels of E-Cadherin generally have a poorer prognosis; the phenomenon of heterogeneous cell migration may be related to this

<p>Histone tails (FreeStockImages)</p>
28 Jul 2015

Researchers at IRB Barcelona discover the molecular mechanism that determines how epigenetic markers influence gene expression

27 Jul 2015

Combination of two strong denaturants of DNA leads to stabilization of the structure

An unexpected finding that opens new fields to the biotechnological use of DNA

22 Jul 2015

A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia (CLL)

CLL is the most frequent leukemia with more than 12,000 new cases diagnosed in Europe every year

IRB Barcelona group leader Modesto Orozco participated in the study as he is involved with the International Cancer Genome Consortium (ICGC)

<p>Structural details of the MH2 domains of Smad2 and 4 , with mutations, shown in orange, found in lung tumours.</p>
13 Jul 2015

Maria Macias, Pau Martín, and Joan Massagué publish a featured review article in Trends in Biochemical Sciences (TIBS) on the Smad protein family, the members of which play a key role in cancer.

The article is accompanied by a web application in which available 3D structures of Smads can be explored, as can their alterations in several metazoa, their variability in humans, and their mutations in tumours.

<p>CEP63 depletion increases stem cell death in the developing mouse brain. The image on the right shows the stem dying cells in purple. The mice are born with microcephaly, a characteristic feature of Seckel Syndrome (Image: Berta Terré, IRB Barcelona)</p>
7 Jul 2015

Researchers at IRB Barcelona study CEP63, a gene that is mutated in Seckel Syndrome, a rare disease that causes microcephaly and growth defects.

The protein CEP63 is crucial for the correct division of brain stem cells. In its absence, mice reproduce Seckel Syndrome.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

Also, CEP63-depleted male mice are infertile. The relationship between this protein and sperm production is revealed for the first time.