Antoni Riera

    Research Group: 
    Research Unit on Asymmetric Synthesis
    Unit: 
    CANCER SCIENCE
    Position: 
    Group Leader
    Office: 
    EM01B11-12
    Telephone: 
    +34 93 40 37093
    Email: 
    antoni.riera@irbbarcelona.org

    Professor (Organic Chemistry Dept. - UB)

     

    View research group

    Born in Balsareny (Barcelona, Spain) in 1957.

    He studied Chemistry at the University of Barcelona, where he performed his Doctoral thesis under the supervision of professors Fèlix Serratosa and Miquel A. Pericàs. After a post-doctoral stage in the University of Pennsylvania (Philadelphia, USA) under the supervision of Prof. Amos B. Smith III, he returned to the Department of Organic Chemistry as assistant professor (profesor Titular) in 1988. In June 2003 he was promoted to full professor (catedrático de Química Orgánica) of the University of Barcelona.

    His main research area is asymmetric synthesis. He has been working in the synthesis of biologically active products such as amino acids and amino alcohols and in the development of enantioselective versions of the Pauson-Khand reaction. In all these fields he has directed ten doctoral theses and co-authored more than one hundred twenty publications in international journals.

    Selected group publications

    Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
    Albert Cabré, Sergi Rafael, Giuseppe Sciortino, Gregori Ujaque, Xavier Verdaguer, Agustí Lledós, Antoni Riera
    Angew Chem Int Edit, 59 (19), 7521-7527 (2020)
    Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst
    Salomó E, Gallen A, Sciortino G, Ujaque G, Grabulosa A, Lledós A, Riera A and Verdaguer X.
    J Am Chem Soc, 140 16967-1697 (2018)
    Total Synthesis of ( R)-Sarkomycin Methyl Ester via Regioselective Intermolecular Pauson-Khand Reaction and Iridium-Catalyzed Asymmetric Isomerization
    Cabré A, Khaizourane H, Garçon M, Verdaguer X and Riera A.
    Org Lett, 20 (13), 3953-3957 (2018)
    TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
    Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS and Batlle E.
    Nature, 554 (7693), 538-543 (2018)
    Stereospecific SN2@P reactions: novel access to bulky P-stereogenic ligands
    Orgué S, Flores-Gaspar A, Biosca M, Pàmies O, Diéguez M, Riera A and Verdaguer X.
    Chem Commun, 55 (99), 17548-51 (2015)
    Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
    de la Fuente A, Mena-Barragán T, Farrar-Tobar RA, Verdaguer X, García Fernández JM, Ortiz Mellet C and Riera A.
    Org Biomol Chem, 13 (23), 6500-10 (2015)
    Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
    Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello DV, Byrom D, Cortina C, Morral C, Barceló C, Tosi S, Riera A, Attolini CS, Rossell D, Sancho E and Batlle E.
    Nat Genet, 47 (4), 320-329 (2015)
    Asymmetric Intermolecular Cobalt-Catalyzed Pauson-Khand Reaction Using a P-Stereogenic Bis-phosphane
    Orgué S, León T, Riera A and Verdaguer X.
    Org Lett, 17 (2), 250-3 (2015)
    MaxPHOS Ligand: PH/NH Tautomerism and Rhodium- Catalyzed Asymmetric Hydrogenations
    Cristobal-Lecina E, Etayo P, Doran S, Reves M, Martin-Gago P, Grabulosa A, Costantino A R, Vidal-Ferran A, Riera A, Verdaguer X.
    Adv Synth Catal, 356 (4), 795-804 (2014)
    Stereodivergent SN2@P Reactions of Borane Oxazaphospholidines: Experimental and Theoretical Studies
    Zijlstra H, León T, de Cózar A, Guerra CF, Byrom D, Riera A, Verdaguer X and Bickelhaupt FM.
    J Am Chem Soc, 135 (11), 4483-91 (2013)
    Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group
    Aiguabella N, del Pozo C, Verdaguer X, Fustero S and Riera A.
    Angew Chem Int Edit, 52 (20), 5355-9 (2013)
    P-stereogenic secondary iminophosphorane ligands and their rhodium(I) complexes: taking advantage of NH/PH tautomerism
    León T, Parera M, Roglans A, Riera A and Verdaguer X
    Angew Chem Int Edit, 51 (28), 6951-5 (2012)
    Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
    Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E and Batlle E.
    Cancer Cell, 22 (5), 571-84 (2012)
    Fine-tuning the π-π aromatic interactions in peptides: somatostatin analogues containing mesityl alanine
    Martín-Gago P, Gomez-Caminals M, Ramón R, Verdaguer X, Martin-Malpartida P, Aragón E, Fernández-Carneado J, Ponsati B, López-Ruiz P, Cortes MA, Colás B, Macias MJ and Riera A.
    Angew Chem Int Edit, 51 (8), 1820-5 (2012)
    SSTR1- and SSTR3-Selective Somatostatin Analogues
    Ramón R, Martín-Gago P, Verdaguer X, Macias MJ, Martin-Malpartida P, Fernández-Carneado J, Gomez-Caminals M, Ponsati B, López-Ruiz P, Cortés MA, Colás B and Riera A.
    Chembiochem, 12 (4), 625-32 (2011)
    Stereoselective synthesis of P-stereogenic aminophosphines: ring opening of bulky oxazaphospholidines
    León T, Riera A and Verdaguer X.
    J Am Chem Soc, 133 (15), 5740-3 (2011)
    Primary and secondary aminophosphines as novel P-stereogenic building blocks for ligand synthesis
    Revés M, Ferrer C, León T, Doran S, Etayo P, Vidal-Ferran A, Riera A and Verdaguer X.
    Angew Chem Int Edit, 49 (49), 9452-5 (2010)
    Full publication list