Macarena Sánchez

    Research Group: 
    Design, synthesis and structure of peptides and proteins
    Unit: 
    CHEMISTRY & MOLECULAR PHARMACOLOGY
    Position: 
    Research Associate
    Office: 
    EM01B21-22
    Telephone: 
    +34 93 40 37127
    Email: 
    macarena.sanchez@irbbarcelona.org

     

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    Selected group publications

    Blood-brain barrier peptide shuttles
    Sánchez-Navarro M, Giralt E and Teixidó M.
    Curr Opin Chem Biol, 38 134-140 (2017)
    Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose
    Lo Re D, Jones L, Giralt E and Murphy P.
    Chem-Asian J, 11 (14), 2035-40 (2016)
    Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery
    Oller-Salvia B, Sánchez-Navarro M, Giralt E and Teixidó M.
    Chem Soc Rev, 45 (17), 4690-707 (2016)
    MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery
    Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.
    Angew Chem Int Edit, 55 (2), 572-5 (2016)
    Lipid Bilayer Crossing-The Gate of Symmetry. Water-Soluble Phenylproline-Based Blood-Brain Barrier Shuttles
    Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M and Giralt E.
    J Am Chem Soc, 137 (23), 7357-64 (2015)
    Lipid bilayer crossing - the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier-shuttles
    Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzman F, Teixidó M and Giralt E.
    J Am Chem Soc, (2015)
    Applying the retro-enantio approach to obtain a Peptide capable of overcoming the blood-brain barrier
    Prades R, Oller-Salvia B, Schwarzmaier SM, Selva J, Moros M, Balbi M, Grazú V, de La Fuente JM, Egea G, Plesnila N, Teixidó M and Giralt E.
    Angew Chem Int Edit, 54 (13), 3967-72 (2015)
    Modulating protein-protein interactions: the potential of peptides
    Nevola L and Giralt E.
    Chem Commun, 51 3302-3315 (2015)
    Absence of a stable secondary structure is not a limitation for photoswitchable inhibitors of β-arrestin/β-Adaptin 2 protein-protein interaction
    Martín-Quirós A, Nevola L, Eckelt K, Madurga S, Gorostiza P and Giralt E.
    Chem Biol, 22 (1), 31-7 (2015)
    Delivering wasp venom for cancer therapy.
    Moreno M, Zurita E, Giralt E.
    J Control Release, 182 13-21 (2014)
    Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease
    Pujadas L, Rossi D, Andrés R, Teixeira CM, Serra-Vidal B, Parcerisas A, Maldonado R, Giralt E, Carulla N and Soriano E.
    Nat Commun, 5 3443 (2014)
    Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death
    Serra-Vidal B, Pujadas L, Rossi D, Soriano E, Madurga S and Carulla N.
    Acs Chem Biol, 9 (11), 2678-85 (2014)
    From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog
    Oller-Salvia B, Teixidó M and Giralt E.
    Biopolymers, 100 (6), 675-86 (2013)
    Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis
    Nevola L, Martín-Quirós A, Eckelt K, Camarero N, Tosi S, Llobet A, Giralt E and Gorostiza P.
    Angew Chem Int Edit, 52 (30), 7704-8 (2013)
    Shuttle-Mediated Drug Delivery to the Brain
    Malakoutikhah M, Teixidó M and Giralt E.
    Angew Chem Int Edit, 50 7998-8014 (2011)
    Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E)
    Martín I, Teixidó M and Giralt E.
    Chembiochem, 12 (6), 896-903 (2011)
    Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties
    Sánchez L, Madurga S, Pukala T, Vilaseca M, López-Iglesias C, Robinson CV, Giralt E and Carulla N.
    J Am Chem Soc, 133 (17), 6505-8 (2011)
    Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange
    Carulla N, Zhou M, Giralt E, Robinson CV and Dobson CM.
    Accounts Chem Res, 43 (8), 1072-9 (2010)
    Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand
    Gordo S, Martos V, Santos E, Menéndez M, Bo C, Giralt E and de Mendoza J.
    P Natl Acad Sci Usa, 105 (43), 16426-31 (2008)
    Redesign of protein domains using one-bead-one compound combinatorial chemistry
    Pastor JJ, Granados G, Carulla N, Rabanal F and Giralt E
    J Am Chem Soc, 129 14922-32 (2007)
    Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
    Pujals S, Fernandez-Carneado J, Kogan M, Martinez J, Cavelier F and Giralt E
    J Am Chem Soc, 128 8479-83 (2006)
    Full publication list