Amino acid transporters and disease news

<p>The BIST founding conference took place on 31st March at the CCCB in Barcelona. (Image: BIST)</p>
4 Apr 2017

The announcement took place during the BIST Founding Conference on Friday 31 March at the Centre de Cultura Contemporània de Barcelona.

10 Feb 2017

Several specialized websites have echoed the review article on Mitochondrial Dynamics headed by researchers at IRB Barcelona and Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM).

Aging is associated with a decline in mitochondrial function and accumulation of abnormal mitochondria. In this work, published in Trends in Molecular Medicine (Cell Press), David Sebastián, Manuel Palacín and Antonio Zorzano, summarize information about mitochondrial dynamics...

<p>The "Create your own monster" workshops aims to teach children about the genetic code</p>
14 Jun 2016

IRB Barcelona is to hold three workshops for all kinds of public

2 Dec 2014 has published an article that includes statements made by Manuel Palacín after the “Transporters and other Molecular Machines” conference, part of Barcelona Biomed Conferences, which is organised by IRB Barcelona with the support of the BBVA Foundation.

Hosted by IRB Barcelona researchers Manuel Palacín and Miquel Coll, this conference addressed the latest technological advances in membrane protein determination. Given that many of these proteins have the capacity to enter cells, the determination of their structures may allow the design of smart drugs for many types of diseases.

21 Nov 2014

Article on the Barcelona BioMed conference on membrane proteins, organised by IRB Barcelona and the BBVA Foundation. According to statements made by the organisers Manuel Palacín and Miquel Coll, both at IRB Barcelona, research into the structure of these proteins "paves the way to a wide range of possibilities for the development of new drugs for diseases that currently have no cure and to search for alternative treatments in other conditions for which current drugs are not overly efficient or...

17 Nov 2014

Coverage in the media of the 25th Barcelona BioMed Conference on membrane proteins—molecules that account for 30% of the human genome. To date, the atomic structures of only 3% of these proteins are known from an estimated 15,000. More than 50% of current drugs target membrane proteins, thus indicating the immense therapeutic potential for relevant functions that cells undertake.

In a conference organised by the Fundación BBVA and IRB Barcelona in Barcelona, 150 international scientists are brought together to debate membrane protein functions, atomic resolution techniques...

17 Nov 2014

30% of human proteins exert their function in cell membranes and more than 50% act on these proteins.

New high-resolution microscopes and 3D calculation programmes are crucial to increase the number of atomic structures available, which currently stands at 440, this figure representing 3% of the estimated 15,000 that exist.

Today sees the start of a three-day conference in Barcelona involving 150 international scientists invited by the BBVA Foundation and IRB Barcelona.

<p>Manuel Palacín is a world expert in heteromeric amino acid transporters (HATs). (Author: Battista/Minocri)</p>
11 Feb 2014

Researchers at IRB Barcelona, BSC, and the University of Bern observe the first structure of a human HAT at low resolution.

HAT amino acid transporters are involved in pathologies such as aminoacidurias, cancer, viral infections and cocaine addiction.

The breakthrough published in the Proceedings of the National Academy of Science USA allows researchers to delve into the functions of HATs and to address the rational drug design of inhibitors.

The study has been partially funded by the European project EDICT (European Drug Initiative on Channels and Transporters), devoted to increasing the number of membrane protein structures available.

12 Nov 2013

Salvador Aznar-Benitah, Angel R. Nebreda, Modesto Orozco, and Manuel Palacín are beneficiaries of funds raised in the 2012 “Marató” destined to fight cancer.

The IRB Barcelona projects—one individual and three coordinated—are to receive approx. 1.2 M€.

Having raised more than 11 M€, “La Fundació” will financially support 47 projects carried out by 79 researchers over the next three years.

28 Feb 2011

The specialized medical newspaper Diario Médico reports on results recently published by scientists at IRB Barcelona that describe the 3D structures adopted by a number of critical cell transporters. Headed by Manuel Palacín and ICREA professor José Luis Vázquez, the study has been published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), one of the most cited journals in biological, physical and social sciences.