Amino Acid Transporters and Disease news

<p>Structure of the BasC transporter. </p>
24 Apr 2019

ABC and Gaceta Médica, among other media, have echoed on a study about the structure of a member of the L-amino acid transporter family (LAT), headed by IRB Barcelona researcher Manuel Palacín. “Knowing how LATs recognise the amino acids that they have to introduce into the cell allows us to better understand their function and helps us decipher the molecular defects associated with different pathologies and thus to develop potential treatments,” says Palacín.

Link to ABC

Link to Gaceta...

<p>Structure of the BasC transporter. Manuel Palacín, IRB Barcelona.</p>
24 Apr 2019

Mutations in L-amino acid transporters (LATs) can lead to a wide range of conditions, such as autism, hearing loss and aminoacidurias.

Published in the journal Nature Communications, this study presents key data on how amino acids bind to these transporters.

The work is a collaboration between IRB Barcelona, CIBERER, IBMB-CSIC and the Barcelona Supercomputing Center.

<p>Different localization of the proteins involved in apoptosis in basal (Ctrl) and upon death receptor induction with TRAIL. Saška Ivanova, IRB Barcelona</p>
15 Apr 2019

Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis.

A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments.

<p>Image: University of Barcelona</p>
13 Apr 2018

The new study analyses the dysfunction of basolateral transporters through a transgenic animal model.

This study is led by Manuel Palacín from IRB Barcelona and Virgínia Nunes from IDIBELL.

<p>Mitochondrial DNA stress (in red) triggers the inflammatory response in mouse muscle cells devoid of Opa1 (nuclei in green). Aida Rodríguez, IRB Barcelona</p>
9 Apr 2018

A study performed at IRB Barcelona supports the notion that mitochondrial defects underlie a set of diseases of unknown origin that involve chronic muscle inflammation.

<p>Age-related hearing loss involves several environmental factors and genes. Image: CIBERER</p>
23 Feb 2018

It seems the amino acid transporter SLC7A8/SLC3A2 plays an important role in this disease.

The study was coordinated by Manuel Palacín from IRB Barcelona and Virginia Nunes from IDIBELL.

<p>The BIST founding conference took place on 31st March at the CCCB in Barcelona. (Image: BIST)</p>
4 Apr 2017

The announcement took place during the BIST Founding Conference on Friday 31 March at the Centre de Cultura Contemporània de Barcelona.

10 Feb 2017

Several specialized websites have echoed the review article on Mitochondrial Dynamics headed by researchers at IRB Barcelona and Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM).

Aging is associated with a decline in mitochondrial function and accumulation of abnormal mitochondria. In this work, published in Trends in Molecular Medicine (Cell Press), David Sebastián, Manuel Palacín and Antonio Zorzano, summarize information about mitochondrial dynamics...

<p>The "Create your own monster" workshops aims to teach children about the genetic code</p>
14 Jun 2016

IRB Barcelona is to hold three workshops for all kinds of public

2 Dec 2014

Excelenciencia.org has published an article that includes statements made by Manuel Palacín after the “Transporters and other Molecular Machines” conference, part of Barcelona Biomed Conferences, which is organised by IRB Barcelona with the support of the BBVA Foundation.

Hosted by IRB Barcelona researchers Manuel Palacín and Miquel Coll, this conference addressed the latest technological advances in membrane protein determination. Given that many of these proteins have the capacity to enter cells, the determination of their structures may allow the design of smart drugs for many types of diseases.