Amino acid transporters and disease news

<p>Image: University of Barcelona</p>
13 Apr 2018

The new study analyses the dysfunction of basolateral transporters through a transgenic animal model.

This study is led by Manuel Palacín from IRB Barcelona and Virgínia Nunes from IDIBELL.

<p>Mitochondrial DNA stress (in red) triggers the inflammatory response in mouse muscle cells devoid of Opa1 (nuclei in green). Aida Rodríguez, IRB Barcelona</p>
9 Apr 2018

A study performed at IRB Barcelona supports the notion that mitochondrial defects underlie a set of diseases of unknown origin that involve chronic muscle inflammation.

<p>Age-related hearing loss involves several environmental factors and genes. Image: CIBERER</p>
23 Feb 2018

It seems the amino acid transporter SLC7A8/SLC3A2 plays an important role in this disease.

The study was coordinated by Manuel Palacín from IRB Barcelona and Virginia Nunes from IDIBELL.

<p>The BIST founding conference took place on 31st March at the CCCB in Barcelona. (Image: BIST)</p>
4 Apr 2017

The announcement took place during the BIST Founding Conference on Friday 31 March at the Centre de Cultura Contemporània de Barcelona.

10 Feb 2017

Several specialized websites have echoed the review article on Mitochondrial Dynamics headed by researchers at IRB Barcelona and Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM).

Aging is associated with a decline in mitochondrial function and accumulation of abnormal mitochondria. In this work, published in Trends in Molecular Medicine (Cell Press), David Sebastián, Manuel Palacín and Antonio Zorzano, summarize information about mitochondrial dynamics...

<p>The "Create your own monster" workshops aims to teach children about the genetic code</p>
14 Jun 2016

IRB Barcelona is to hold three workshops for all kinds of public

2 Dec 2014

Excelenciencia.org has published an article that includes statements made by Manuel Palacín after the “Transporters and other Molecular Machines” conference, part of Barcelona Biomed Conferences, which is organised by IRB Barcelona with the support of the BBVA Foundation.

Hosted by IRB Barcelona researchers Manuel Palacín and Miquel Coll, this conference addressed the latest technological advances in membrane protein determination. Given that many of these proteins have the capacity to enter cells, the determination of their structures may allow the design of smart drugs for many types of diseases.

21 Nov 2014

Article on the Barcelona BioMed conference on membrane proteins, organised by IRB Barcelona and the BBVA Foundation. According to statements made by the organisers Manuel Palacín and Miquel Coll, both at IRB Barcelona, research into the structure of these proteins "paves the way to a wide range of possibilities for the development of new drugs for diseases that currently have no cure and to search for alternative treatments in other conditions for which current drugs are not overly efficient or...

17 Nov 2014

Coverage in the media of the 25th Barcelona BioMed Conference on membrane proteins—molecules that account for 30% of the human genome. To date, the atomic structures of only 3% of these proteins are known from an estimated 15,000. More than 50% of current drugs target membrane proteins, thus indicating the immense therapeutic potential for relevant functions that cells undertake.

In a conference organised by the Fundación BBVA and IRB Barcelona in Barcelona, 150 international scientists are brought together to debate membrane protein functions, atomic resolution techniques...

17 Nov 2014

30% of human proteins exert their function in cell membranes and more than 50% act on these proteins.

New high-resolution microscopes and 3D calculation programmes are crucial to increase the number of atomic structures available, which currently stands at 440, this figure representing 3% of the estimated 15,000 that exist.

Today sees the start of a three-day conference in Barcelona involving 150 international scientists invited by the BBVA Foundation and IRB Barcelona.