Complex Metabolic Diseases and Mitochondria news

<p>Different localization of the proteins involved in apoptosis in basal (Ctrl) and upon death receptor induction with TRAIL. Saška Ivanova, IRB Barcelona</p>
15 Apr 2019

Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis.

A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments.

<p>Antonio Zorzano, head of the Complex Metabolic Diseases and Mitochondria Lab</p>
11 Dec 2018

The newspaper El País has published an article on the pros and cons of intermittent fasting. The article refers to two kinds of fasting, namely the 5:2 fast, on which you can eat with no calorie restriction for five days and on the other two days no solids are allowed, and the 18:6 fast, which proposes that all the meals of the day are eaten within 6 hours, while the remaining 18 are devoted to fasting. The article includes the opinion of IRB Barcelona researcher Antonio Zorzano, who says, "I have still not seen this reflected in studies, but we must err on the side of caution before telling  people that they can do these diets ", and goes on to conclude that people on such diets should...

<p>Montserrat Romero, Antonio Zorzano, David Sebastián and Juan Pablo Muñoz from the Complex Metabolic Diseases and Mitochondria Lab at IRB Barcelona. Source: Fundación BBVA</p>
6 Sep 2018

A project headed by Antonio Zorzano at IRB Barcelona has been awarded funding from the BBVA Foundation to explore a possible link between ageing and cancer.

Called MitoFuss, the project focuses on the mitochondrial protein Mitofusin 2.

5 Jun 2018

This weekend the Ciutadella Park will be hosting this event, which will showcase 230 scientific activities aimed at the general public.

IRB Barcelona will be participating through two workshops and a micro-talk, related to microscopy, cancer research and ageing.

<p>Antonio Zorzano, head of the Complex Metabolic Diseases and Mitochondria Lab</p>
7 May 2018

RNE has interviewed Antonio Zorzano, head of the Complex Metabolic Diseases and Mitochondria lab at IRB Barcelona, about his research on DOR protein deficiency. Depletion of this protein stimulates the generation of new adipose cells and leads to a less toxic form of obesity. In the interview, Zorzano says that this study will allow the identification of therapeutic targets, which in turn will allow the development of new drugs. This will be a step forward as only three approved drugs are available through a medical prescription in Spain and they are not totally effective.

Link to RNE...

<p>Antonio Zorzano, group leader of the Complex Metabolic Diseases and Mitochondria Laboratory at IRB Barcelona.</p>
23 Apr 2018

El Periódico, Cuatro, Medical Xpress, Scienmag, among other national and international media, have published an article about a study done at IRB Barcelona that has unveiled the mechanism that leads to a less harmful form of obesity that is associated with the number rather than the volume of fat cells.

Link to El Periódico

Link to Cuatro...

<p>Mouse cells with DOR protein. (M. Romero, IRB Barcelona)</p>
19 Apr 2018

Researchers at IRB Barcelona discover the mechanism that leads to a less harmful form of obesity that is associated with the number rather than volume of fat cells.

There are several types of obesity and some are more harmful than others.

The study has been published in the journal Nature Cell Biology.

<p>Pathological accumulation of mitochondria in mouse skeletal muscle devoid of Opa1. Aida Rodríguez, IRB Barcelona</p>
16 Apr 2018

La Vanguardia, Diario Médico, GEN, Technology Networks, among other national and international media, have published an article about a recent study performed at IRB Barcelona that supports the notion that mitochondrial defects underlie a set of diseases of unknown origin that involve chronic muscle inflammation.

Link to La Vanguardia

Link to...

<p>Antonio Zorzano, head of the Complex Metabolic Diseases and Mitochondria Lab</p>
13 Apr 2018

Gen magazine, Phys Org, News Medical Life Sciences, among other international media, have published an article on the latest study led by Antonio Zorzano from IRB Barcelona, which supports the notion that mitochondrial defects underlie a set of diseases of unknown origin that involve chronic muscle inflammation.

Link to GEN

Link to Phys Org

Link to...

<p>Image: University of Barcelona</p>
13 Apr 2018

The new study analyses the dysfunction of basolateral transporters through a transgenic animal model.

This study is led by Manuel Palacín from IRB Barcelona and Virgínia Nunes from IDIBELL.