Complex Metabolic Diseases and Mitochondria news

23 Mar 2012

One of the most prestigious biotech and health websites, Fierce Biotech Research, reports on the discovery made by Antonio Zorzano’s group at IRB Barcelona. Published in PNAS, the study addresses the validation of Mitofusin 2 as a posible therapeutic target for type 2 diabetes.

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<p>Hepatic cells isolated from healthy mice and mice deficient in Mitofusin 2 (right). Morphology of mitochondria (red), more rounded, is altered in the image on the right</p>
23 Mar 2012

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin 2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations. These are the two most common conditions prior to development of diabetes type 2. Published in this week’s issue of Proceedings of the National Academy of Sciences (PNAS), the study validates Mitofusin 2 as a possible target for the treatment of diabetes type 2.

“Resistance to insulin plays a key role in the development of diabetes mellitus, dyslipidemia (alteration of lipid...

<p>Antonio Zorzano at IRB Barcelona</p>
4 May 2011

In an act held last April during the XXII National Congress of the Spanish Society of Diabetes (SED) Antonio Zorzano, coordinator of the Molecular Medicine Programme at IRB Barcelona was awarded the IV “Alberto Sols Senior Investigator Award for Basic Research”. Presented by Bernat Soria, ex-president of the SED and ex-minister of Health, this award is in recognition of Zorzano’s career dedicated to the study of the causes of diabetes.

In 1991, Zorzano was one of the youngest Senior Professors in Spain in the...

10 Aug 2010

The magazine Ictineus is a platform the Generalitat de Catalunya has developed to bring closer to the society the research carried on in Catalonia. In the last edition it publishes an interview with Antonio Zorzano, coordinator of the Molecular Medicine Programme at IRB Barcelona. The section, that includes an interview with Xesco Espar, coordinator of physical preparation of FC Barcelona, tries to figure out where the limits of the workout capacity.

9 Aug 2010

In a double-page spread, the newspaper La Vanguardia focuses on sport from a scientific perspective and includes statements by Antonio Zorzano, coordinator of the Molecular Medicine Programme at IRB Barcelona. The article reports on a recent study carried out by the Massachusetts General Hospital that has found that physically active people burn calories more efficiently than sedentary people. Zorzano explains what happens in the cells during exercise and why this is beneficial to health.

12 Mar 2010

The study on diabetes type 2 co-directed by the head of the Molecular Medicine Programme at IRB Barcelona, Antonio Zorzano, together with John Nolan at Trinity College, Dublin, has been echoed in several health webs and digital newspapers.

<p>Graphic about the different responses of mitochondrial gens of young obese subjects with or without diabetes during physical exercise</p>
10 Mar 2010

A genetic variation in mitochondria, the energy-producing machinery of cells, prevents young obese subjects with diabetes type 2 to respond to physical exercise.

25 Jan 2010

AstraZéneca, a leading company in drug research and development, informs about news from IRB Barcelona on a new gene that participates in autophagy. The researchers, led by senior professor of the University of Barcelona at IRB Barcelona, Antonio Zorzano, have published the study in EMBO Reports.