Design, Synthesis and Structure of Peptides and Proteins news

<p>Tetsuya Terasaki co-chaired a recent Barcelona BioMed Conference with Ernest Giralt dedicated to the Blood-Brain Barrier (BBB).</p>
26 Sep 2016

IRB Barcelona and the Graduate School of Pharmaceutical Sciences of the Tohoku University in Japan have signed a new academic exchange agreement. In August, the Dean of the Japanese institution and IRB Barcelona Director Joan J. Guinovart endorsed a long-standing collaboration between scientists at the two centres.


15 Sep 2016

Extensive impact of Natàlia Carulla’s work at IRB Barcelona on a new method through which to study neuron death in Alzheimer’s disease.

Published in PNAS, the study addresses the effects of an amyloid protein aggregate that has the capacity to perforate the neuronal cell membrane—a process that may cause the toxicity of these aggregates and that could be validated as a therapeutic target.

Link to La Vanguardia:

<p>Beta amyloid protein and AD are strongly linked but the role of this protein in this disease remains elusive. Hippocampus of transgenic mice overexpressing amyloid beta. In blue, neuronal nuclei. In green, beta amyloid plaques (E.Verdaguer/S.Brox)</p>
13 Sep 2016

Researchers at IRB Barcelona describe for the first time how to prepare a specific type of aggregate of the amyloid-beta protein with the ability to perforate the cell membrane.

What causes neuron death and the subsequent cognitive decline in Alzheimer´s disease is still unknown.

<p>Shuttle peptides are molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system</p>
25 Aug 2016

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently.

IRB Barcelona is one of the few centres worldwide with a specific line of research devoted to this field, which brings together chemistry, pharmacy and biomedicine.

The article appears on the cover of the journal Chemical Society Reviews.

<p>Salvador Guardiol holds a  “la Caixa/Severo Ochoa” scholarship from 2013</p>
11 Mar 2016

“I’m still enthusiastic. Just a bit less naïve.” Salva Guardiola, PhD student in Ernest Giralt’s Design, Synthesis, and Structure of Peptide and Proteins Lab, has just published his first paper in ChemBioChem. And in the life of a researcher, the first article is never forgotten, it leaves a mark the rest of your career.

The idea Salva and his colleagues had was to design and test a peptide,...

5 Feb 2016

The medical portal ""El Médico Hospitaliario" and other media report on IRB Barcelona's research on compounds able to act against EGF, a little-explored cancer target.
The study has been published in ChemBioChem.

Link to La Vanguardia

Link to...

<p>The compound Cp28 (orange) binds to the EGF protein (green), a target in cancer. This interaction prevents EGF from binding to its receptor EGFR.</p>
3 Feb 2016

The molecules synthesized by Ernest Giralt’s lab at IRB Barcelona bind a key protein in cancer that has received little attention as a therapeutic target.

The long-term goal is to provide a new chemotherapy treatment.

<p>Laura Nevola</p>
27 Jan 2016

After seven intense years in Ernest Giralt’s lab, Laura Nevola (Benevento, Italy, 1980) is ready to undertake a new challenge in her career. “It’s time to fly on my own,” she says.

18 Dec 2015

This award recognizes his thesis, which addressed the use of shuttle peptides to overcome the blood-brain barrier.

27 Nov 2015

Professor Ernest Giralt talks about the blood-brain barrier on the blog Activa tu Neurona. In the podcast, he explains how this barrier works and also draws an analogy between the work done at his lab and a famous fairy tale, which illustrates his research.