Design, Synthesis and Structure of Peptides and Proteins news

12 Jan 2015

Radio 5 (RNE) interviews Meritxell Teixidó, associate researcher in the Peptide and Protein Laboratory at IRB Barcelona, about the line of investigation on substances capable of crossing the hematoencephalic barrier —a structure that protects the brain from infection. Teixidó talks about a new peptide that they have produced based on apamine, a peptide present in bee venom. This finding would allow the design of new drugs to treat diseases of the central nervous system. Another project related to these peptides is the treatment of glioblastoma, a joint project conducted with Joan Seoane, researcher at the “Hospital Vall d’Hebron” Oncology Institute (VHIO).

Listen to the interview...

<p>Diagram of a possible structure adopted by the oligomers in the cell membrane</p>
31 Dec 2014

The project, led by Natàlia Carulla, has been awarded funds from “La Marató de TV3” initiative held in 2013.

The project, which will be undertaken over three years, aims to verify a new therapeutic target to fight Alzheimer’s.

12 Dec 2014

“La Sexta Columna” television programme has broadcasted a report about the initiative taken by families with relatives that suffer from Friedreich’s Ataxia, a rare illness with no cure. Joined in an association called Genefa, these families raised the funds necessary to launch a research project – involving IRB Barcelona - to find a treatment.

The programme featured Juan Carlos Baiges, head of the association, Meritxell Teixidó, partner researcher in the Peptide and Protein Laboratory at IRB Barcelona, and Javier López Nido, researcher at the Severo Ochoa Centre of Molecular Biology in Madrid, with whom Teixidó works in coordination to carry the project forward.

Watch the...

26 Nov 2014

Interview with Teresa Tarragó, co-founder together with Ernest Giralt of the spin-off Iproteos, about the discovery of new drugs for diseases that affect the central nervous system.
Tarragó explains the scope for biotech business opportunities is very big. "The projects have great potential but require a lot of funding. During the valorisation, spin-offs need more support, " says Tarragó. The IRB Barcelona researchers states that in Catalonia there are lots of good ideas but that "if we want more technology transfer we will have to make it carry greater weight when evaluating a researcher’s scientific production."

17 Nov 2014

Extensive article published in Sunday’s issue of ARA on the research line developed by Meritxell Teixidó in Ernest Giralt’s lab to extract natural poison from bees, scorpions and spiders, which provides peptides able to cross the blood-brain barrier. Many drugs cannot enter the brain because of this barrier, which serves to protect this organ against infections. Several projects at IRB Barcelona seek to find and modify natural peptide venoms that have the capacity to cross this barrier without damaging it, in order to use them as drug transporters into the brain.

 

11 Nov 2014

Extensive report on three "crowdfunding" initiatives, among them one led by
the company Iproteos, co-funded by researchers at IRB Barcelona.

9 Nov 2014

Extensive article about the various research projects undertaken by Ernest Giralt’s group at IRB Barcelona. The article focuses on those devoted to the design of peptides with the capacity to cross the blood-brain barrier. “I think we are the only group worldwide studying the use of poisons as transporters of new drugs into the brain,” explains Ernest Giralt, full professor of the UB and coordinator of the Chemistry and Molecular Pharmacology Programme at IRB Barcelona.

28 Oct 2014

Diario Médico reports on a study by Ernest Giralt’s lab (two pages) published in the Journal of Controlled Release on the design of a peptide capable of eliminating tumour cells. The peptide in question exploits the properties of wasp venom.

21 Oct 2014

The company Iproteos, a spin-off from IRB Barcelona cofounded by Ernest Giralt and Teresa Tarragó, both researchers at IRB, has already surpassed 80% of the funding requested in a fundraising campaign that was launched in mid 2014. This news is echoed in El Periódico de Catalunya. The objective is to finance a drug for the treatment of schizophrenia.

18 Oct 2014

Natàlia Carulla, associate researcher at IRB Barcelona devoted to studying
the aggregation of the protein beta-amyloid, which is strongly associated
with Alzheimer's disease, explains her approach to reveal the role of this
protein in this neurodegenerative disease, a condition that affects millions
of elderly people worldwide.

In a study recently published in ACS Chemical Biology, Carulla describes the
aggregation structures of beta-amyloid that are toxic for neurons.