The study, published in the journal Developmental Cell and performed in Drosophila, unravels how developmental genes regulate organ size and proportions.
Researchers at IRB Barcelona demonstrate that the size and patterning of a given organ are regulated by different mechanisms.
Given the high genetic and mechanistic conservation between flies and humans, these discoveries pave the way for new research lines into congenital malformations and other diseases
“Cinc dies a...” broadcasted by La2 has devoted a programme to the day to day lives of all those who work at the Barcelona Science Park, ranging from researchers to admin staff and other service staff. Several members of the IRB Barcelona community participated in the programme. Lara Barrio, a researcher with the Growth Control and Development Lab, showed how studying the vinegar fly Drosophila can help us to understand human diseases. In the Colorectal Cancer Lab, the scientists Elena Sancho and Carme Cortina explained their research into colon cancer and metastasis. In addition, Silvia Frutos, Alumna of IRB Barcelona, commented on how she founded her company...
Researchers at IRB Barcelona and IAL Santa Fe in Argentina have found the cell-signalling factor TNFα to be critical for coordinated organ growth in the fruit fly Drosophila melanogaster.
Regulated by the tumour suppressor p53, TNFα enables the tissue to detect and reverse growth defects.
These findings allow researchers to better understand tissue development better, and they are also relevant for diseases such as cancer.
The programme El Matí, broadcasted on Catalunya Ràdio, and the newspapers La Vanguardia and El Punt Avui, among other media, have echoed on a study led by Marco Milán, head of the Development and Growth Control Laboratory at IRB Barcelona. This study reports on the team’s success in selectively eliminating cells that express the oncogene RAS. This oncogene is activated in 30% of humans cancers, and no effective inhibitors of this protein had been identified to date.
In a study published in Cell Reports,the scientists inhibited the capacity of RAS to block cell death, thus eliminating malignant tumours without affecting the development of organs.
The results of the study pave the way to combining irradiation treatments with the administration of RAS pathway inhibitors to eliminate tumour cells.
From 7 to 11 February, the general public will have the opportunity to participate in activities related to ageing, nanoscience and climate change, among others.
IRB Barcelona will be taking part in the Biennal event through three initiatives that target the public.
La Vanguardia, Biotech, Salud y Medicina, among other media, have published an article on the study led by IRB Barcelona researcher Marco Milán. The study shows that chromosomal instability itself can induce invasive behaviour in epithelial cells, and identifies the underlying molecular mechanisms involved.
Link to La Vanguardia
Link to Biotech...
Most solid tumours with metastatic potential show a high degree of chromosomal instability.
A study published in the journal Developmental Cell demonstrates that chromosomal instability itself promotes invasive behaviour.
The researchers identify the oncogene Fos and the tumour suppressor Capicua as necessary molecular elements mediating this invasive behaviour.
La Vanguardia reports on a recent study published by Marco Milán’s lab in the journal Developmental Cell. On the basis of their findings in the fruit fly (Drosophila melanogaster), the scientists have concluded that the chromosomal instability characteristic of tumours can promote invasive behaviour in cancer.
Link to La Vanguardia: Demuestran que la inestabilidad cromosómica de tumores promueve la metástasis (in Spanish)
BIYSC 2018 starts with 90 students from all over the world.
IRB Barcelona receives today eight students that will participate through the workshop "Drosophila melanogaster: a model to study human disease".