Development and Growth Control Laboratory news

<p>p53 target genes (green) are upregulated in undergrowing cell populations (magenta).</p>
4 Sep 2019

Researchers at IRB Barcelona and IAL Santa Fe in Argentina have found the cell-signalling factor TNFα to be critical for coordinated organ growth in the fruit fly Drosophila melanogaster.

Regulated by the tumour suppressor p53, TNFα enables the tissue to detect and reverse growth defects.

These findings allow researchers to better understand tissue development better, and they are also relevant for diseases such as cancer.

<p>Proliferative and invasive capacity of tumour cells (centre) compared to normal cells (left) and effect of TRAMETINIB treatment, which reduces the invasive capacity and tumoural load (right). Marco Milán, IRB Barcelona.</p>
11 Jul 2019

The programme El Matí, broadcasted on Catalunya Ràdio, and the newspapers La Vanguardia and El Punt Avui, among other media, have echoed on a study led by Marco Milán, head of the Development and Growth Control Laboratory at IRB Barcelona. This study reports on the team’s success in selectively eliminating cells that express the oncogene RAS. This oncogene is activated in 30% of humans cancers, and no effective inhibitors of this protein had been identified to date.

Link to...

<p>Proliferative and invasive capacity of tumour cells (centre) compared to normal cells (left) and effect of TRAMETINIB treatment, which reduces the invasive capacity and tumoural load (right). Marco Milán, IRB Barcelona.</p>
3 Jul 2019

In a study published in Cell Reports,the scientists inhibited the capacity of RAS to block cell death, thus eliminating malignant tumours without affecting the development of organs.

The results of the study pave the way to combining irradiation treatments with the administration of RAS pathway inhibitors to eliminate tumour cells.

<p>Biennal Ciutat i Ciència</p>
16 Jan 2019

From 7 to 11 February, the general public will have the opportunity to participate in activities related to ageing, nanoscience and climate change, among others.

IRB Barcelona will be taking part in the Biennal event through three initiatives that target the public.

<p>Drosophila epithelium subjected to chromosomal instability (CIN): cells start invading the neighbouring tissues. Magenta labels the nuclei of all the epithelium while green labels the membranes of cells subjected to CIN (L Barrio, IRB Barcelona)</p>
1 Oct 2018

La Vanguardia, Biotech, Salud y Medicina, among other media, have published an article on the study led by IRB Barcelona researcher Marco Milán. The study shows that chromosomal instability itself can induce invasive behaviour in epithelial cells, and identifies the underlying molecular mechanisms involved.

Link to La Vanguardia

Link to Biotech...

<p>Drosophila epithelium subjected to chromosomal instability (CIN): cells start invading the neighbouring tissues. Magenta labels the nuclei of all the epithelium while green labels the membranes of cells subjected to CIN (L Barrio, IRB Barcelona)</p>
26 Sep 2018

Most solid tumours with metastatic potential show a high degree of chromosomal instability.

A study published in the journal Developmental Cell demonstrates that chromosomal instability itself promotes invasive behaviour.

The researchers identify the oncogene Fos and the tumour suppressor Capicua as necessary molecular elements mediating this invasive behaviour.

26 Sep 2018

La Vanguardia reports on a recent study published by Marco Milán’s lab in the journal Developmental Cell. On the basis of their findings in the fruit fly (Drosophila melanogaster), the scientists have concluded that the chromosomal instability characteristic of tumours can promote invasive behaviour in cancer.

Link to La Vanguardia: Demuestran que la inestabilidad cromosómica de tumores promueve la metástasis (in Spanish)

<p>Image: La Pedrera</p>
6 Jul 2018

BIYSC 2018 starts with 90 students from all over the world.

IRB Barcelona receives today eight students that will participate through the workshop "Drosophila melanogaster: a model to study human disease".

<p>Joan Massagué, director of the Sloan Kettering Institute of New York. Image: Jordi Casañas (Mahala, IRB Barcelona)</p>
15 Mar 2018

High-ranking figures from the business and innovation sectors attended an event organised by IRB Barcelona and ESADE with the aim to highlight the importance of uniting all sectors of society against metastasis.

<p>Colon cancer stem cells, in green (G. Turon, IRB Barcelona)</p>
13 Mar 2018

Advances in research into the immunological evasion, metabolism and latency of metastatic cancer cells allow the identification of potential targets to test therapies.

IRB Barcelona and the BBVA Foundation invite 20 renowned international scientists working in the field of cancer metastasis to a gathering in Barcelona.

After the scientific conference, IRB Barcelona and ESADE have organised a debate on how to translate scientific research to society.