Catalunya Press, Revista Genética, among other national and international media, have published articles about a study co-led by Travis H. Stracker, head of the Genomic Instability and Cancer Lab, which has identified a key role for enzymes in DNA replication and sensitivity to chemotherapeutic drugs.
Link to Catalunya Press
Link to Revista Genética
Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.
Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.
Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials
A new study in collaboration with the Genomic Instability and Cancer Laboratory at IRB Barcelona and led by the University of Copenhagen, reveals that TLK2 displays lower levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive.
The study suggests that the enzyme may be a target for potential therapies.
A conference organised by IRB Barcelona and the BBVA Foundation brings together leading international researchers devoted to two cell organelles that play key roles in health and disease.
Cancer and certain developmental disorders are characterised by impaired activity of these complex cell structures and defects in cell cycle control.
The video series Meet Our Scientists presents Travis Stracker, head of the Genomic Instability and Cancer lab at IRB Barcelona.
The video “Maintaining stability of the genome” highlights the research underway to unravel how cells prevent genomic instability.
Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.
This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.
The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
Several media have echoed research by IRB Barcelona researcher Travis H. Stracker on the key role of the TLK2 gene for the development of the placenta and for embryo viability in mice.
Published in the journal Cell Death and Differentiation, this finding may be of biomedical relevance. A recent massive genomics study of people with intellectual disabilities performed in the Netherlands points to TLK2 mutations in this population.
Selected media mentions
Link to EFE Futuro
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The work is the first to report on the key role of the TLK2 gene in mouse embryo development.
The study solidifies an important role for both TLK1 and TLK2 in genome stability.
A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.
A study published this week in the journal Angewandte Chemie presents a new methodology that uses Nuclear Magnetic Resonance (NMR) to study cell metabolism.
The technology was developed by scientist Òscar Yanes in the Metabolomics Platform, a facility created by the Univeristat Rovira i Virigili (URV) in Tarragona (Spain) and CIBERDEM, with the collaboration of IRB Barcelona group leader Travis Stracker and former PhD student Suvi Aivio.
The tool makes it possible to monitor metabolic fluxes more quickly than previous methods. In just 10 minutes it can provide dynamic...
The magazine of "Genética Médica News” publishes an article by Berta Terré, PhD student in the Genomic Instability and Cancer Laboratory, about the discovery of Gemc1. This new gene is essential for the generation of multiciliated cells and the association these may have with ciliopathies, a type of rare disease.