Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.
This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.
The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.
Several media have echoed research by IRB Barcelona researcher Travis H. Stracker on the key role of the TLK2 gene for the development of the placenta and for embryo viability in mice.
Published in the journal Cell Death and Differentiation, this finding may be of biomedical relevance. A recent massive genomics study of people with intellectual disabilities performed in the Netherlands points to TLK2 mutations in this population.
Selected media mentions
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The work is the first to report on the key role of the TLK2 gene in mouse embryo development.
The study solidifies an important role for both TLK1 and TLK2 in genome stability.
A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.
A study published this week in the journal Angewandte Chemie presents a new methodology that uses Nuclear Magnetic Resonance (NMR) to study cell metabolism.
The technology was developed by scientist Òscar Yanes in the Metabolomics Platform, a facility created by the Univeristat Rovira i Virigili (URV) in Tarragona (Spain) and CIBERDEM, with the collaboration of IRB Barcelona group leader Travis Stracker and former PhD student Suvi Aivio.
The tool makes it possible to monitor metabolic fluxes more quickly than previous methods. In just 10 minutes it can provide dynamic...
The magazine of "Genética Médica News” publishes an article by Berta Terré, PhD student in the Genomic Instability and Cancer Laboratory, about the discovery of Gemc1. This new gene is essential for the generation of multiciliated cells and the association these may have with ciliopathies, a type of rare disease.
ALN Magazine, a journal devoted to animal research facilities, has devoted an exclusive article to the study performed in Travis Stracker's laboratory and published in EMBO Journal.
After more than 6 years, Helena González (Salamanca, 1983) has left IRB Barcelona to pursue her dream of communicating science. Thanks to Big Van: Científicos Sobre Ruedas, the company she created together with her colleagues from the first Spanish edition of FameLab, she will be working on two European projects within Science With and For Society, a call under the Horizon2020 framework. The two EU projects she is now involved in aim to bring science into secondary school classrooms using drama-based...
Several media channels mentioned the publication of a new study by Travis Stracker, leader of the Genomic Instability and Cancer Laboratory at IRB Barcelona, on the discovery of a gene associated with ciliopathies, a type of rare diseases. The researchers report that the absence of the Gemc1 gene in mice causes the same symptoms as seen in a kind of human ciliopathy, making it a possible diagnostic tool.
IRB Barcelona identifies GEMC1 as a master gene for the generation of multiciliated cells—cells with fine filaments that move fluids and substances—which are found exclusively in the brain, respiratory tract, and reproductive system.
Defects in multiciliated cells lead to ciliopathies—rare and complex diseases that are poorly understood and for which not all causative genes have been identified.
Researchers at IRB Barcelona study CEP63, a gene that is mutated in Seckel Syndrome, a rare disease that causes microcephaly and growth defects.
The protein CEP63 is crucial for the correct division of brain stem cells. In its absence, mice reproduce Seckel Syndrome.
The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.
Also, CEP63-depleted male mice are infertile. The relationship between this protein and sperm production is revealed for the first time.