METCENTRE

The Metastasis Research Centre performs joint investigation on metastasis

The Metastasis Research Centre (MetCentre) brings together multidisciplinary basic research groups from the Institute for Research in Biomedicine (IRB Barcelona) and clinical and translational groups from hospitals and technology platforms in Barcelona, with the aim to perform joint investigation on metastasis.

According to the World Health Organization, cancer is a leading cause of death worldwide and accounted for 8.2 million deaths (13% of all deaths) in 2012. The survival rate has been steadily increasing over the last decade, but the main obstacle for patients, clinicians and scientists to overcome has a daunting name: metastasis, responsible for 90% of current cancer mortality. Thus, research on metastasis is critical: any new knowledge will profoundly affect human health, quality of life, and public health policy. “A small amount of progress in this field could benefit millions,” explains Joan MassaguéChair of IRB Barcelona External Advisory Board, and founder of MetCentre.

 

Facilitating and channelling resources and efforts into causes, mechanisms and treatments of metastasis

Collaborations with other clinical and translational research centres in the metropolitan area of Barcelona

Raising funds from competitive and philanthropic sources

Although metastasis has been considered a major health problem for centuries, the breakthroughs made with respect to its genetic determination, its molecular mechanisms and specific treatments have been minimal.

However, conceptual and technological advances that have arisen in recent years now offer an unprecedented opportunity to tackle this problem. MetCentre will seize this opportunity in order to focus its research on metastasis.

Objectives:

  • To implement and develop multidisciplinary protocols and technology, both in house and externally, with a single aim, namely to identify genes and functions of clinical relevance for cancer and metastasis.
  • To establish a framework or reference to channel all efforts related to metastasis from a transversal and translational perspective.
  • To contribute to the design of new protocols for the prevention, diagnosis and treatment of metastasis.

Institutional cornerstones

Scientists at IRB Barcelona are paving the way towards the discovery of the molecular mechanisms underlying metastasis. The research focuses on the study of the overall metastatic process as well as its individual components: tumour angiogenesis, the progenitor cells that derive from bone marrow, cell motility and adhesion, interactions with the microenvironment of the tumour, and stem cells.

The MetCentre initiative has been brought about within IRB, a reference research centre in Barcelona. The convergence of multidisciplinary disciplines at the institute, organised into five research programmes, namely Cell and Development Biology, Structural and Computational Biology, Molecular Medicine, Chemistry and Molecular Pharmacology, and Oncology, provide an ideal hotbed from which to launch multidisciplinary projects with a specific aim.

Establishment of a regional collaboration network

MetCentre welcomes collaborations with other clinical and translational research centres in the metropolitan area of Barcelona.

Maximizing resources for research

Research into metastasis calls for access to clinical samples (for example, fluids with malignant components, samples of tumours and tissues with metastasis and circulating tumour cells) for the generation of living cell suspensions, research into genetic translation, and inoculation studies on animals. Protocols have recently been drawn up for these purposes.

  • MetCentre seeks to facilitate access to clinical samples for research purposes.
  • The research groups at IRB Barcelona are developing new techniques and experimental models to conduct research into metastasis.
  • MetCentre aims to facilitate the exchange of experimental approaches for research into metastasis. IRB Barcelona has made a considerable investment in scientific platforms that are crucial for cutting-edge research into metastasis.
  • To coordinate efforts for the development of collaborative projects to raise funding from competitive and philanthropic sources.

Metastasis is a highly relevant issue from both a scientific and medical perspective. By devoting its efforts to metastasis at IRB Barcelona, MetCentre will boost the participation of new talent – from students to university lecturers. MetCentre seeks to attract basic and clinical researchers from local and international settings.

A multidisciplinary project for metastasis research

The Severo Ochoa Distinction of Excellence awarded to IRB Barcelona by the Spanish Ministry of Economy and Competitiveness in October 2011, was based in two evaluation criteria: the scientific quality of the centre and a project for the future, namely the Met Project, whose main scientific goal is cancer metastasis. The Severo Ochoa Award involves the allocation of one million euros per year for four years.

A focus on metastasis

IRB Barcelona was established in 2006 on the principle that major biomedical problems should be addressed through a blend of biology, chemistry, biophysics and bioinformatics, with robust ties to relevant clinical resources. This structural multidisciplinary approach is one of the assets that has allowed IRB Barcelona to develop cutting-edge science. The unique convergence and interaction of diverse researchers has led to a critical mass that has paved the way for IRB Barcelona scientists to focus efforts on cancer, one of the most scientifically stimulating challenges and a major health problem worldwide. In 2007 the External Advisory Board highlighted that cancer and metastasis were natural strengths and a de facto “brand” of the Institute.

Metproject scientific core

The focal point addressed by the Met Project stems from the fact that invasive tumours release cancer cells from the onset. Some of these cells infiltrate distant organs and remain in the patient after diagnosis and removal of the primary tumour. As many patients know too well, disseminated tumour cells may lie dormant in the body for long periods of time, depending on the type of cancer, until explosive, lethal outgrowth of metastasis ensues. It is precisely this latent phase of the metastatic process that will be targeted in the Met Project using an interdisciplinary approach.

A challenge for the entire Institute

The research performed at IRB Barcelona has been shaping the scientific tools that allow the problem of metastasis to be tackled. In order to identify the cell types, tissue niches, gene networks and signalling pathways that support the survival of latent disseminated tumour cells, IRB Barcelona scientists have been working on cutting-edge science on colorectal and breast cancer and on the so-called mediators of metastasis. Modelling obtained through Drosophila studies will be another key piece in the metastasis puzzle. We also know that stress-activated kinases are implicated in the dormancy process and that mRNA translation and genome instability affect the survival and tumour-initiating fitness of disseminated cancer cells. By fostering the synergies already carefully nurtured at the Institute, it will be possible to sketch a promising picture of the mechanisms that underlie metastasis. The following step will be to develop proof-of-concept therapies that target these cells and prevent metastasis with greater effectiveness and less toxicity than the chemotherapy currently available. This will be done only by first transferring candidate drug targets to structural, computational and chemistry labs for structural modelling of preclinical therapeutic agents.

Collaborations

The Met Project would not be feasible without exploiting the solid partnerships with local clinical institutions, such as the Hospital Clínic, Hospital del Mar and Hospital Sant Pau, and scientific institutes, like the Barcelona Supercomputing Center, and internationally, such as the Memorial Sloan-Kettering Cancer Center.

 

A collaborative project on metastasis of breast cancers

Breast Cancer research

breast cancer

Breast cancer is the most frequently diagnosed cancer in women in Europe and the United States. Despite a recent decrease in breast cancer incidence rates, it remains the second leading cause of cancer deaths among women. Nearly all of these deaths are due to the metastatic spread of the tumour. Metastasis occurs when tumor cells acquire the ability to escape their original location and invade healthy tissue and organs elsewhere in the body.

This complex cellular process, virtually unique to cancer, raises fundamental questions about the role that certain genes play in determining how and why tumor cells break free and, once mobile, how they decide where to attack. We have isolated tumor progenitor cells from breast cancer patients and used bioluminescence to select metastatic cells in mice.

With the support of the BBVA Foundation, MetLab project is a pioneer initiative in the development of new concepts and techniques that foster our current understanding of the biology of breast cancer metastasis. Indeed, the data obtained within this project is transferable to metastasis projects in other types of cancer, such as colon and brain.

Under the leadership of Dr. Roger Gomis, IRB Barcelona, and Prof. Joan Massagué, Memorial Sloan Kettering Cancer Center, this is a collaborative project and institutions represented includes other institutions such the Hospital Clínic and IDIBAPS, the Hospital de San Pau, and the Hospital del Mar. Beyond the research collaborations that exist between the investigators and clinicians, this network serves as a forum for internal scientific presentations, discussions of work in progress, and joint efforts to develop new ideas and to attract grant support and new talents to metastasis research.

Scientific directors: Prof. Joan Massagué and Dr. Roger Gomis

In collaboration with

fundación bbva

 

Transferring cancer technology from academia to industry

IRB Barcelona’s missions include not only conducting scientific research of excellence in the field of cancer, but also translating the results of this research into benefits for society. In order to achieve these goals, the Institute, in collaboration with the “la Caixa” Social Programme, launched BioMedTec (formerly known as CancerTec), a platform which aims to fulfill the potential of the results of research in cancer conducted by our researchers. The programme supports IRB Barcelona scientists in their quest to develop diagnostic tools and therapies for cancer and help get these technologies into the market. By creating small, versatile and focussed working groups, we are able to improve processes such as proof of concept and transfer of research results, with the ultimate goal of improving the well-being of our society.

The BioMedTec programme allows us to boost the transfer of results achieved in our laboratories to the market, thereby increasing the quality of life of cancer patients. New diagnostic tools allow physicians to determine how sensitive patients are to a given treatment and to choose a personalized treatment plan which maximizes effectiveness and minimizes secondary effects. The programme also helps researchers discover new compounds for the treatment of cancer and improve those which already exist. All things added up, BioMedTec has great potential to generate new and important social and business opportunities.

obra social la caixa

 

Bringing together clinicians and scientists

MetCentre regularly organizes scientific seminars (MetCentre Sessions). These seminars seek to bring together basic and clinical scientists and foster research collaborations between them.

  • 16 July 2015
    MetCentre Sessions
    Key aspects of brain metastasis biology that generate new therapeutic opportunities
    Speaker: Manuel Valiente, DVM, PhD - Brain Metastasis Group, Molecular Oncology Program, CNIO, Madrid, Spain.
     
  • 18 June 2015
    MetCentre Sessions
    Defining the role of tumor-secreted exosomes in the crosstalk with the microenvironment during metastasis
    Hector Peinado, PhD - Microenvironment & Metastasis Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid
     
  • 12 June 2015
    MetCentre Sessions
    Intrinsic and extrinsic mechanisms of resistance to radiation and immune checkpoint blockade in solid tumors
    Speaker: Andy Minn, MD, PhD - Assistant Professor Dept of Radiation Oncology, and Assistant Investigator Abramson Family Cancer Research Institute - Perelman School of Medicine, University of Pennsylvania (USA)
     
  • 30 June 2014
    MetCentre Sessions
    What's a pediatric tumor?
    Dr. Jaume Mora, Scientific Director, Department of Onco-Hematology and Cancer: molecular biology of tumour development group, Hospital Sant Joan de Déu, Barcelona, Spain
     
  • 1 July 2013
    MetCentre Sessions
    Notch and Wnt signals: from Hematopoietic Stem Cells to Leukemia
    Dr. Anna Bigas, Stem Cells and Cancer Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
     
  • 28 February 2013
    MetCentre Session
    Update in renal Cancer
    Dr. Òscar Reig, Hospital Clínic, Barcelona, Spain
     
  • 12 September 2012
    MetCentre Session
    Spatiotemporal regulation of stem cells in health and disease
    Speaker: Salvador Aznar Benitah,
    Head of Epithelial Homeostasis and Cancer Lab, Dept. Gene Regulation, Stem Cells and Cancer Center for Genomic Regulation (CRG), Barcelona, Spain
     
  • 5 July 2012
    MetCentre Session
    Genetic Mouse Models of Glioma: Cancer Stem Cells and Translational Tool for Therapeutic Development
    Speaker: Luis Parada, PhD,
    UTSouthwestern Medical Center Dallas, TX, USA
     
  • 27 February 2012
    Metcentre sessions
    Targeting cancer and aging: from genes to genomes
    Carloz López-Otín (Univ. Oviedo) IRB
     
  • 19 December 2011
    Metcentre sessions
    Modeling malignant tumor growth in Drosophila
    Cayetano González (IRB) IRB
     
  • 14 November 2011
    Metcentre sessions
    Contribution of Epigenetics to Human Metastasis
    Manel Esteller (PEBC-IDIBELL) IRB
     
  • 12 September 2011
    Metcentre sessions
    From Colon Stem Cells to Colorectal Cancer
    Eduard Batlle (IRB) IRB
     
  • 4 July 2011
    Metcentre sessions
    Pancreatic Cancer: Clinical and Pathological Overview
    Cristina Nadal (Hospital Clínic/ IDIBAPS) and Mar Iglesias (Hospital del Mar/ Parc de Salut Mar) Esther Koplowitz Centre (Hosp. Clínic)
     
  • 9 May 2011
    Metcentre sessions
    TGF-beta and cancer-initiating cells
    Joan Seoane, Institut de Recerca Vall d'Hebron (VHIO) IRB
     
  • 11 April 2011
    Metcentre sessions
    New Roles for LKB1 in Cancer
    Juan Ángel Recio, Institut de Recerca Vall d'Hebron (VHIO) IRB
     
  • 28 February 2011
    Metcentre sessions
    Translational control in tumoral gene expression reprogramming
    Raul Méndez (IRB) IRB
     
  • 31 January 2011
    Metcentre sessions
    The two faces of Anti-angiogenic Therapies: anti-tumor and pro- metastatic effects
    Oriol Casanovas, Institut Català d'Oncologia (ICO) IRB
     
  • 20 December 2010
    Metcentre sessions
    Tumor promoting functions of p38 MAPKs
    Ángel Nebreda (IRB) IRB
     
  • 2 November 2010
    Metcentre sessions
    Breast cancer: a clinical and pathological approach
    Agustí Barnadas/ Enrique Lerma/ Daniel Escuin (H. St. Pau) Hospital St. Pau
     
  • 6 September 2010
    Metcentre sessions
    Understanding the role of the DNA damage response in tumor suppression
    Travis Stracker (IRB) IRB
     
  • 7 July 2010
    Metcentre sessions
    Improving preclinical studies with patient-derived xenograft models
    Yasir Ibrahim (H. Vall d’Hebron, J. Baselga's Lab) Hosp. Vall d’Hebron
     
  • 18 May 2010
    Metcentre sessions
    Mechanisms of metastasis
    Roger Gomis (IRB) IRB
     
  • 2 March 2010
    Metcentre sessions
    Colorectal cancer: oncologic and pathologic approach
    Cristina Nadal (H. Clínic) & Mar Iglesias (Hosp. Mar) IRB
     
  • 23 December 2009
    Metcentre sessions
    Intestinal stem cell genes in colorectal cancer progression and relapse
    Eduard Batlle (IRB) IRB
     
  • 27 September 2009
    Metcentre sessions
    Deconstructing metastasis
    Joan Massagué (SKI, HHMI)
     

 

Participants:

MetCentre Sessions have so far involved participants from the following institutions:

IRB Barcelona (interdisciplinary groups from different programmes)

  • Centre for Genomic Regulation (CRG)
  • IMIM - Hospital del Mar Research Institute
  • Catalan Institute of Oncology (ICO)
  • Vall d’Hebron Institute of Research (VHIO)
  • August Pi i Sunyer Biomedical Research Institute (IDIBAPS)
  • Hospital de la Vall d’Hebron
  • Hospital Clínic de Barcelona
  • Hospital del Mar
  • Hospital de la Santa Creu i de Sant Pau