The Meet Our Scientists video series introduces Jens Lüders, who studies microtubules—mini-filaments involved in multiple cell processes. The alteration of these structures is associated with diseases such as cancer and Alzheimer’s and with developmental defects.
In the video “Curiosity as a fuel”, Lüders recalls that transcendental discoveries arise from basic research and that such science is driven exclusively by curiosity, without specifically pursuing its applicability or transfer.
Extensive media coverage of work by Jens Lüders’ Microtubule Organisation Lab about a novel mechanism by which neurons maintain and regenerate axons. Published in Nature Communications, the study reveals new pathways related to microtubule biology that are relevant for regenerative medicine and research into diseases in which the microtubule network is damaged, such as Alzheimer’s disease.
The study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as Alzheimer’s.
Researchers at IRB Barcelona study CEP63, a gene that is mutated in Seckel Syndrome, a rare disease that causes microcephaly and growth defects.
The protein CEP63 is crucial for the correct division of brain stem cells. In its absence, mice reproduce Seckel Syndrome.
The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.
Also, CEP63-depleted male mice are infertile. The relationship between this protein and sperm production is revealed for the first time.
A breakthrough at IRB Barcelona fills a knowledge gap in understanding how the cell division apparatus, the mitotic spindle, is formed.
The in vivo visualization and monitoring of the starting points of microtubules — filaments responsible for organising the mitotic spindle — provides novel insight into the dynamic architecture of this structure.
The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and that are used in chemotherapy.
"The Nobel Prize in Medicine this year reflects the importance of basic research,” explains the head of the Microtubule Organisation Lab at IRB Barcelona Jens Lüders to Materia. The North American scientists James Rothman and Randy Schekman and the German Thomas Südhof have been awarded this recognition for solving the mystery of how the cell organises its transport...
Collaboration between researchers at the Institut de Biotecnologia i de Biomedicina (IBB) of the “Universitat Autònoma de Barcelona”, the Institute for Biocomputation and Physics of Complex Systems in Zaragoza, and IRB Barcelona has led to the publication of the first scientific paper on data collected from the BL13-XALOC beamline of the Alba Synchrotron, located in Cerdanyola de Vallès, a facility that which allows scientists to obtain 3D structures of macromolecular complexes.
The team at IRB Barcelona headed by the research associate Joan Roig...
150 international researchers specialized in organelles associated with cell transport and mobility and related diseases are brought together in Barcelona by IRB Barcelona and the BBVA Foundation.
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