La Razón newspaper has published an article on the grants given by the European Research Council (ERC) to five researchers in Barcelona. Among these grants is the ERC Proof of Concept that Modesto Orozco, head of the Molecular Modelling and Bioinformatics Lab at IRB Barcelona, has received. This grant will allow him to optimise and validate "2shRNA", a tool that can simultaneously attack two therapeutic targets involved in drug resistance pathways and that can also bind to other molecules to enhance their delivery and efficacy.
IRB Barcelona scientist, Modesto Orozco has been granted 150,000 euros to optimise and validate a promising anti-tumour therapeutic tool over 18 months.
The Community Research and Development Information Service of the European Union (CORDIS) has echoed the SimDNA project conducted by Modesto Orozco and funded through an ERC Advanced Grant. The project has developed multiscale DNA simulation technologies to understand in detail the mechanisms that control gene expression.
Link to CORDIS
The programme “24 Horas”, broadcasted by Radio Nacional de España, has interviewed IRB Barcelona researcher Modesto Orozco, co-organiser of the Barcelona Biomed Conference.
From November 13 to 15, this meeting gathered more than twenty experts in the field, with the aim to share advances made in 3D genomics.
Link to Radio Nacional de España (interview starts at 19:40)
Various media, including El Progreso, the Diario de Pontevedra and Biotech Spain, have echoed the Barcelona Biomed Conference. From November 13 to 15, more than twenty experts shared the advances made in 3D genomics, a field that is expected/has the capacity to unravel the underlying causes of many diseases. Modesto Orozco, leader of the Molecular Modelling and Bioinformatics group at IRB Barcelona, was a co-organiser of the event.
Link to Biotech Spain
Specialists advance toward the “Google Earth” of the genome, which will allow them to see the detailed structure of DNA folded within the nucleus, from atomic resolution to the level of the entire molecule
3D genomics promises to reveal the hidden layer of gene regulation and allow researchers to uncover the causes of many diseases
20 world leaders in 3D genomics will meet today until Wednesday in Barcelona at the Barcelona BioMed Conference organized by IRB Barcelona and the BBVA Foundation.
Scientists in the Multiscale Complex Genomics (MuG) Consortium are working on new cloud-based computational infrastructure to support and improve the existing genome analysis tools. The beta-version of the Virtual Research Environment (VRE) was presented for the first time in Cambridge in April. MuG is a Horizon 2020 project coordinated by IRB Barcelona Group Leader Modesto Orozco.
p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions.
Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors.
These findings are the result of combining fundamental biological data using computational techniques.
The journal Phys.org reports on the research performed by IRB Barcelona scientists. In the study, these researchers have provided an integrative picture of the p38α activation mechanism and new insights into the molecular effects of various molecules that regulate the enzymatic activity of this protein.
The first author of this study is Antonija Kuzmanic, an EU Marie Curie COFUND fellow who is undertaking postdoctoral training simultaneously in two IRB Barcelona labs — the Molecular Modelling and Bioinformatics Laboratory and the Signalling and Cell Cycle Laboratory.
Link to Phys.org...