Molecular modelling and bioinformatics news

<p>Multiscale Complex Genomics (MuG) is a Horizon 2020 project coordinated by IRB Barcelona Group Leader Modesto Orozco</p>
18 Jul 2017

Scientists in the Multiscale Complex Genomics (MuG) Consortium are working on new cloud-based computational infrastructure to support and improve the existing genome analysis tools. The beta-version of the Virtual Research Environment (VRE) was presented for the first time in Cambridge in April. MuG is a Horizon 2020 project coordinated by IRB Barcelona Group Leader Modesto Orozco.

<p>Researchers revealed details of the p38 activation mechanism. The image represents the structural changes from the inactive state (purple) to the active one (green) proposed by X-ray crystallography. Image: Antonija Kuzmanic.</p>
27 Apr 2017

p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions.

Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors.

These findings are the result of combining fundamental biological data using computational techniques.

27 Apr 2017

The journal Phys.org reports on the research performed by IRB Barcelona scientists. In the study, these researchers have provided an integrative picture of the p38α activation mechanism and new insights into the molecular effects of various molecules that regulate the enzymatic activity of this protein. 

The first author of this study is Antonija Kuzmanic, an EU Marie Curie COFUND fellow who is undertaking postdoctoral training simultaneously in two IRB Barcelona labs — the Molecular Modelling and Bioinformatics Laboratory and the Signalling and Cell Cycle Laboratory.

Link to Phys.org

...
<p>Participants in the IV National Congress of Entrepreneurial Scientists in Barcelona. From left to right, Iliana López, Daniela Kalafatovic, Anna Bellmunt, Alba Olivares, Saska Ivanova, Sanja Zivanovic, Gonzalo Fernández-Miranda.</p>
11 Apr 2017

An innovative programme from IRB Barcelona’s Innovation Department enables researchers to explore how to implement their entrepreneurial ideas

<p>The BIST founding conference took place on 31st March at the CCCB in Barcelona. (Image: BIST)</p>
4 Apr 2017

The announcement took place during the BIST Founding Conference on Friday 31 March at the Centre de Cultura Contemporània de Barcelona.

<p>When he was young, Enrique Marcos was attracted to science because he was curious and wanted to discover new things. "And, if on top of that it could be useful to society, even better.”</p>
6 Feb 2017

Postdoc Enrique Marcos (Barcelona 1982) is a chemist, a theoretical chemist to be exact. He has just published his first paper in Science, in which he explains how to computationally design the pocket-like cavities of proteins—essential areas that allow many proteins to perform their functions. And he has just been awarded a second Marie Skłodowska-Curie Action Fellowship.

 

<p>Examples of computationally designed proteins made of curved beta-sheets and helices forming cavities with different sizes and shapes (E.Marcos, IRB Barcelona-UW)</p>
16 Jan 2017

The local newspaper “La Mañana Diari de Ponent” has echoed a computational study of proteins performed by an international team led by the University of Washington (UW) in Seattle. The first author of the study, Enrique Marcos, is currently working in IRB Barcelona's Molecular Modelling and Bioinformatics Lab.

Published in Science, the study has deciphered key rules that govern how proteins form pocket-like structures that are essential for many key protein functions.

Other media mentions: 

Link to Sinc Agency

Link to ...

<p>Examples of computationally designed proteins made of curved beta-sheets and helices forming cavities with different sizes and shapes (E.Marcos, IRB Barcelona-UW)</p>
13 Jan 2017

The international team achieved it by discovering the rules behind a type of protein structures that are essential for the interaction between proteins and small molecules

IRB Barcelona researcher, Enrique Marcos, is the first author of the study published today in Science

<p>Eadweard Muybridge's pictures of a galloping horse enabled detailed analysis of animals and humans in motion. Today's protein research is faced with a similar situation when trying to understand how proteins move. (L. Orellana)</p>
5 Sep 2016

Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.

They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.

<p>Eva Novoa's mother receives the Young Researchers Award in her name</p>
21 Jul 2016

Eva Novoa was one of the first students to complete a PhD in as part of the ”la Caixa”/IRB Barcelona International PhD Programme in Biomedicine. She was a PhD student at IRB Barcelona between 2008 and 2012. Six months ago, she moved to Sydney, Australia to join the Garvan Institute of Medical Research as a Senior Research Officer. She just received the Young Research Award from the Catalan Society for Biology.