The journal Phys.org reports on the research performed by IRB Barcelona scientists. In the study, these researchers have provided an integrative picture of the p38α activation mechanism and new insights into the molecular effects of various molecules that regulate the enzymatic activity of this protein.
The first author of this study is Antonija Kuzmanic, an EU Marie Curie COFUND fellow who is undertaking postdoctoral training simultaneously in two IRB Barcelona labs — the Molecular Modelling and Bioinformatics Laboratory and the Signalling and Cell Cycle Laboratory.
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An innovative programme from IRB Barcelona’s Innovation Department enables researchers to explore how to implement their entrepreneurial ideas
The announcement took place during the BIST Founding Conference on Friday 31 March at the Centre de Cultura Contemporània de Barcelona.
Postdoc Enrique Marcos (Barcelona 1982) is a chemist, a theoretical chemist to be exact. He has just published his first paper in Science, in which he explains how to computationally design the pocket-like cavities of proteins—essential areas that allow many proteins to perform their functions. And he has just been awarded a second Marie Skłodowska-Curie Action Fellowship.
The local newspaper “La Mañana Diari de Ponent” has echoed a computational study of proteins performed by an international team led by the University of Washington (UW) in Seattle. The first author of the study, Enrique Marcos, is currently working in IRB Barcelona's Molecular Modelling and Bioinformatics Lab.
Published in Science, the study has deciphered key rules that govern how proteins form pocket-like structures that are essential for many key protein functions.
Other media mentions:
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The international team achieved it by discovering the rules behind a type of protein structures that are essential for the interaction between proteins and small molecules
IRB Barcelona researcher, Enrique Marcos, is the first author of the study published today in Science
Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.
They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.
Eva Novoa was one of the first students to complete a PhD in as part of the ”la Caixa”/IRB Barcelona International PhD Programme in Biomedicine. She was a PhD student at IRB Barcelona between 2008 and 2012. Six months ago, she moved to Sydney, Australia to join the Garvan Institute of Medical Research as a Senior Research Officer. She just received the Young Research Award from the Catalan Society for Biology.
The Barcelona International Youth Science Challenge (BIYSC) is a singular programme run by the Catalunya-La Pedrera Foundation that seeks to bring together students with a passion for science and the best scientists in prestigious research centres in Catalonia.
IRB Barcelona participates in the BIYSC through the project “From DNA to protein related diseases”, which includes sessions about the different fields addressed at the institute.
Several media have picked up on the launch of the new biotechnology company Nostrum BioDiscovery, a joint initiative between IRB Barcelona and the Barcelona Supercomputing Center-National Supercomputing Center (BSC-CNS). Modesto Orozco, group leader of the Molecular Modelling and Bioinformatics lab at IRB Barcelona, will chair the new spin-off, which aims to launch new drugs and biotech molecules developed using computational simulation.