The research, published in the journal Nature Genetics,
has addressed the genome of 100 patients with leukaemia and identified
that more than 1000 genes are mutated in the development of this
This study is a significant step forward to achievement of the
objectives set out by the Spanish Chronic Lymphocytic Leukaemia Genome
Awarded by the European Research Council and providing funding of
around 2 and 3 million Euros over five years, ERC Advanced Grants are
given to a limited number of senior scientists.
The multidisciplinary project awarded within the category of
Physical Sciences and Engineering is specialized in chemistry and
computational biology, structural biology, biophysics, and
bioinformatics and will have direct applications in several fields of
biomedicine, such as the regulation of gene expression, and epigenetic
Proteins, the molecular machines that carry out the majority of the functions within a cell, are typically seen as possessing a specific three-dimensional structure. Cellular processes (e.g. reproduction) are activated or deactivated by a molecular choreography that involves the binding of one protein to another. Of late, it has been recognized that even a small protein (say, of size 50 residues) can binding to multiple partners – this results in an advantageous situation for the cell wherein depending on the identity of the partner a different functional response can be generated. In parallel, it has become increasingly evident that a single static structure is a poor representation...
In “L’Observatori”, broadcasted by Radio4, IRB Barcelona researcher Modesto Orozco explains his research efforts devoted to the development of new drugs that improve the people’s quality of life. The agreements drawn up by his laboratory with various I+D programmes from the private sector are good examples of these efforts.
Several national media, such as La Vanguardia and RTVE, echoed the publication of the genome sequence of chronic lymphocytic leukemia in last Sunday’s advanced online version of Nature. The study, which involves Modesto Orozco and Josep L. Gelpí, both with the Joint Programme on Computational Biology between IRB Barcelona and the Barcelona Supercomputing Center (BSC), does not end here. Cells of 500 patients will be analyzed, with the hope of identifying alterations in cellular mechanisms that might serve as therapeutic targets in this disease.
Using state-of-the-art technology, they seek to unraveled the genome of patients with chronic lymphocytic leukemia and give new key insights into the disease.
The study, which is a scientific milestone in this country, identifies four genes whose mutation causes this kind of leukemia.
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The agreements drawn up by IRB Barcelona with various I+D programmes aim to strengthen technology transfer in order to benefit society.
IRB Barcelona and the BSC show their commitment to computational biology by renewing the Joint IRB-BSC Programme, which also doubles in the number of researchers involved.
The programme aims to position itself as an international leader in computational biology.