Research News

<p>Age-related hearing loss involves several environmental factors and genes. Image: CIBERER</p>
23 Feb 2018

It seems the amino acid transporter SLC7A8/SLC3A2 plays an important role in this disease.

The study was coordinated by Manuel Palacín from IRB Barcelona and Virginia Nunes from IDIBELL.

<p>The overexpression of the gene Serpent in the Drosophila wing causes permanent overgrowth and it is sufficient to promote tumour development. Image: Kyra Campbell, IRB Barcelona</p>
19 Feb 2018

In spite of the difference between the cell functions responsible for giving rise to a tumour and for the metastasis of this same tumour, studies at IRB Barcelona using the fly Drosophila melanogaster reveal that some genes can drive both phenomena.

<p>The image shows a metastatic colon tumour infiltrated by the immune system (brown) after combined treatment with the TGF-beta inhibitor and immunotherapy.  (Author: Daniele Tauriello, IRB Barcelona)</p>
14 Feb 2018

A team headed by ICREA researcher Eduard Batlle discovers that immune system-stimulating treatments combined with a TGF-beta inhibitor are effective against colon cancer.

The researchers developed a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for the first time.

<p>Image shows the interaction between the MH1 domain of Smad4 in complex with the GGCGC site  (Maria Macias, IRB Barcelona)</p>
29 Jan 2018

A study published in Nature Communications and led by Maria J Macias highlight new DNA motifs for the Smads proteins.

<p>Nuclei of metastatic breast cancer cells showing the protein MSK1 in green (Author: Cristina Figueras-Puig, IRB Barcelona)</p>
22 Jan 2018

A team of scientists headed by Roger Gomis at IRB Barcelona reveals one of the mechanisms that allows metastatic cells to leave a latent state.

<p>Manuel Serrano Lab</p>
19 Jan 2018

It is a factor that has been conserved through evolution, from plants to mammals

RPAP1 regulates the activity of RNA polymerase II by means of its interaction with gene transactivators

<p>Cells with elongated mitochondrial network in red. Image: David Sebastián, IRB Barcelona</p>
18 Jan 2018

A team headed by Antonio Zorzano at IRB Barcelona has identified activators of the mitochondrial protein Mitofusin 2 for the treatment of type 2 diabetes.

The protein is a key regulator of many mitochondrial functions, as well as of the cell as a whole.

<p>Confocal microscopy shows co-localization of EXD2 (magenta) with the mitochondrial ribosome (yellow). DNA is stained to define the nucleus (cyan).</p>
16 Jan 2018

Published in Nature Cell Biology (NCB), the study shows that the EXD2 protein is critical for the mitochondria, the cell’s powerhouses, to produce energy.

This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.

The results contribute to our basic understanding of mitochondria and suggest that EXD2 could be important for fertility and represent a potential target for cancer therapy.

<p>Tip of a Drosophila testis. In red, BigH1 expressed in germ stem cells and spermatocytes. In blue, the cell nuclei. Image: Albert Carbonell, IRB Barcelona.</p>
13 Dec 2017

Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.

The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility.

Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.

<p>The image shows interactions between the androgen receptor protein (AR) and the TFIIF protein in red. (Author: Paula Martínez-Cristóbal)</p>
12 Dec 2017

Xavier Salvatella, ICREA researcher at IRB Barcelona, ​​proposes a new approach to combat prostate tumour cells that have become unresponsive to the treatments currently available.

The incidence of prostate cancer is increasing worldwide. In the US and Europe, it is one of the most common tumours and among the main causes of death by cancer.