Research News

<p>The DNAzyme 9DB1, whose catalytically active structure and reaction mechanism was unknown, makes use of a mechanism involving two ions, similar to that used by natural enzymes (J. Aranda, IRB Barcelona).</p>
20 Jun 2019

Modesto Orozco’s lab (IRB Barcelona) has published a study on the reaction mechanism of DNAzymes in Nature Catalysis.

DNAzymes, which are catalysers formed by DNA, have applications in biomedicine and biotechnology. These research results will contribute to advances in the design and improvement of catalysers for therapeutic purposes.

<p>The asymmetry of DNA-RNA hybrids can be used to improve the efficiency of gene editing technologies like CRISPR-Cas9 (M Terrazas, IRB Barcelona)</p>
13 Jun 2019

Modesto Orozco’s laboratory (IRB Barcelona) has published a study on the source of asymmetry between nucleic acid hybrid (RNA and DNA) in CHEM (Cell Press).

The results are a promising step towards enhancing gene therapies, which are applicable to many diseases.

<p>The androgen receptor helix of polyglutamine becomes increasingly stable as the number (n) of glutamine amino acid residues increases.</p>
12 Jun 2019

Kennedy’s disease is an untreatable neuromuscular disorder considered a rare disease

A study led by Xavier Salvatella may pave the way for new lines of treatment for Kennedy’s disease

<p>Illustrated view of the different conformations adopted by a flexible small molecule. Colours represent different ensembles of conformations.</p>
6 Jun 2019

A study done by scientists at IRB Barcelona can simulate and predict the shape of a molecule in function of its environment.

These results mark a milestone for the computational design of molecules with specific shape and features for agrochemical, technological and pharmaceutical applications.

<p>Cross section of healthy efferent ducts photographed with a fluorescent microscope</p>
4 Jun 2019

The research group led by Travis Stracker identifies genes involved in male infertility in mice.

Their findings are relevant in humans and could explain undiagnosed cases of male infertility or subfertility.

<p>Valentina Maria Zinna, Salvador Aznar Benitah, Patrick Welz and Inés Marín Guillén, IRB Barcelona.</p>
31 May 2019

In mice whose body clock—an internal mechanism located in the brain—does not work properly, each tissue still knows what time it is and has the capacity to respond to changes in light intensity.

The study, published in the journal Cell, is a collaboration between IRB Barcelona and the University of California, Irvine (US).

<p>Andreu Casali</p>
28 May 2019

This research will help to identify those genes that play a key role in the initiation of metastasis

Metastasis causes 90% of cancer related deaths

<p>Antonio Zorzano and his team at the Complex Metabolic Diseases and Mitochondria Lab have participated in this study. IRB Barcelona.</p>
3 May 2019

Work headed by scientist Antonio Zorzano proposes a possible therapeutic target to treat fatty liver, a disease for which there is currently no treatment. 

The study, which was done in collaboration with the Pere Virgili Institute, has been published in the journal Cell.

<p>Structure of EGFR. Purple indicates the region recognised by mAB806. Laura Orellana.</p>
2 May 2019

The antibody mAb806 is used to treat glioblastoma, although its mechanism of action has been unknown until now. 

The study, published in the journal PNAS, paves the way to extend treatment with mAb806 to more types of tumours and to the development of more personalised therapies. 

<p>Structure of the BasC transporter. Manuel Palacín, IRB Barcelona.</p>
24 Apr 2019

Mutations in L-amino acid transporters (LATs) can lead to a wide range of conditions, such as autism, hearing loss and aminoacidurias.

Published in the journal Nature Communications, this study presents key data on how amino acids bind to these transporters.

The work is a collaboration between IRB Barcelona, CIBERER, IBMB-CSIC and the Barcelona Supercomputing Center.