Research News

<p>Picture of the three crystal systems examined in this study. These systems contain (from left to right) 27, 24 and 36 double-stranded DNA respectively. Pablo Dans Puiggròs, IRB Barcelona.</p>
21 Jan 2019

The breakthrough made by researchers at IRB Barcelona allows the study of the role of each molecular component in the stability and conformation of DNA crystals.

The new molecular simulation techniques are expected to reduce the time and cost of obtaining crystals in the laboratory.

<p>Maximum likelihood phylogenetic tree based on ADAT2 and ADAT3 amino acid sequences. Source: Molecular Biology and Evolution</p>
10 Jan 2019

The study, published in the journal Molecular Biology and Evolution, has been headed by Lluís Ribas, at IRB Barcelona.

<p>Scheme of the intracellular processing of the 2shRNAs by the activity of Dicer enzyme, producing two independent fragments of shRNA, one against each target (M Terrazas, IRB Barcelona)</p>
21 Dec 2018

Modesto Orozco’s lab has published a paper in Chemical Communications about a therapeutic tool to prevent treatment resistance in breast cancer.

The tool has been tested in tumour cells in vitro and will now need to be tested in animal models before moving on to the development of a valid treatment for patients.

<p>A invasive front of highly aggressive tumour cells (in green). Confocal microscopy image. Alexandra Avgustinova, IRB Barcelona.</p>
19 Nov 2018

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.

Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.

<p>Giant Yellow Israeli scorpion. Image: Ester Inbar</p>
14 Nov 2018

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain. 

The barrier, which protects the brain, prevents drugs used for the treatment of neurological diseases and brain tumours from entering the organ.

<p>Skin of a young mouse. The image shows a cross section of the skin with the fibroblasts indicated in green. The thickness of the dermis and the density of fibroblasts is much greater in young skin than in aged skin– cell nuclei, in blue (M Salzer, IRB Bar</p>
8 Nov 2018

A study in mice done at IRB Barcelona and CNAG-CRG explains that dermal fibroblasts lose their cell identify over time and with it their capacity to produce and secrete collagen and other proteins.

<p>The DNA molecule, formed by a double helix, winds around histone molecules twice, thus forming nucleosomes. The pink regions indicate those enriched in Adenine/Thymine base pairs (Author: Iris Joval Granollers)</p>
1 Nov 2018

The team headed by Núria López-Bigas has published an article in Cell about what might have favoured the periodicity of certain base pairs in the genomes of eukaryotic organisms.

The structure adopted by DNA when packaged inside cells influences the periodicity observed.

<p>Figure showing the binding of a nanobody derived from alpaca to the EGF protein. The scientists demonstrate the high affinity and selectivity of a family of nanobodies for EGF, target of interest for the treatment of cancer (S Guardiola, IRB Barcelona)</p>
2 Oct 2018

A study done at IRB Barcelona and the Vrije Universiteit Brussel identifies camelid nanobodies able to block EGF, a protein that is abundant in tumour cells and that helps them to proliferate.

<p>Drosophila epithelium subjected to chromosomal instability (CIN): cells start invading the neighbouring tissues. Magenta labels the nuclei of all the epithelium while green labels the membranes of cells subjected to CIN (L Barrio, IRB Barcelona)</p>
26 Sep 2018

Most solid tumours with metastatic potential show a high degree of chromosomal instability.

A study published in the journal Developmental Cell demonstrates that chromosomal instability itself promotes invasive behaviour.

The researchers identify the oncogene Fos and the tumour suppressor Capicua as necessary molecular elements mediating this invasive behaviour.

<p>Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona</p>
16 Aug 2018

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism

Published in Nature, the study indicates that a defect in CPEB4 could be the link between environmental factors that alter brain development and the genes that determine susceptibility to autism