Research News

7 Apr 2020

The Centre for Genomic Regulation (CRG) is coordinating a task force with the Institute for Research in Biomedicine (IRB Barcelona) and the Institute for Bioengineering of Catalonia (IBEC), as requested by Generalitat de Catalunya, to set up mass testing for citizens to stop the spread of the new coronavirus outbreak.

There will be two mass testing sites – one coordinated by the CRG at its labs at the Barcelona Biomedical Research Park (PRBB) and another at the Parc Cientific de Barcelona, jointly coordinated by IRB Barcelona, IBEC and the Centro Nacional de Análisis Genómico (CNAG-CRG), part of the CRG.

The project, codenamed Programa Orfeu by the Generalitat de Catalunya...

<p> Cells of the yeast Saccharomyces cerevisiae in  the mitosis phase of the cell cycle</p>
6 Apr 2020

The HOG signalling pathway regulates the stress response in the yeast Saccharomyces cerevisiae and halts cell division, thereby regulating the segregation of chromosomes through protein Net1.

The p38 signalling pathway in humans is equivalent to that of HOG and is involved in tumour development.

The study by the Signaling Laboratory at IRB Barcelona has been published in the journal PNAS.

3 Apr 2020

·       The tool is based on Chemical Checker technology, developed by the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona.

·       The aim is to use artificial intelligence to generate a drug database that includes all the published scientific results related to the treatment of COVID-19.

·       This open access database will provide researchers from around the world with an expanded portfolio of molecules with the potential to fight COVID-19.

<p>Eduard Batlle, head of the Colorectal Cancer Laboratory at IRB Barcelona</p>
31 Mar 2020

The ICREA researcher at IRB Barcelona obtains €2.5 M to identify residual cells that cause relapse after treatment.

This is the fifth ERC grant awarded to Eduard Batlle, and the 20th at IRB Barcelona.

21 Feb 2020

The study, published in the journal Developmental Cell and performed in Drosophila, unravels how developmental genes regulate organ size and proportions.

Researchers at IRB Barcelona demonstrate that the size and patterning of a given organ are regulated by different mechanisms.

Given the high genetic and mechanistic conservation between flies and humans, these discoveries pave the way for new research lines into congenital malformations and other diseases

<p>The Pan-Cancer project showed that there is a molecular clock in our cells. (Rayne Zaayman-Gallant/EMBL)</p>
5 Feb 2020
  • Pan-Cancer Project discovers causes of previously unexplained cancers, pinpoints cancer-causing events and zeroes in on mechanisms of development
  • IRB Barcelona researchers, as part of an international team, contribute to the most comprehensive study of whole cancer genomes to date, significantly improving our fundamental understanding of cancer and signposting new directions for its diagnosis and treatment.
<p>Schematic representation of the approach followed. In the center, an illustration showing genes (represented by lines) that are shared between lineages (represented by the color of the lines). In the outside, pictures of representatives of the main animal</p>
28 Jan 2020

The study infers the genetic changes that coincided with the appearance of different groups of animals and their main traits.

Researchers at IRB Barcelona and BSC-CNS have confirmed that the dynamics of genomic evolution, in addition to the presence or absence of the genes themselves, determines diversity in the animal kingdom.

Published in Nature Ecology and Evolution, the study has been based for the first time on the genomic data of all the large groups of animals.

<p>Lung tumor stained for proliferating cells (brown) (IRB Barcelona)</p>
20 Jan 2020

Ángel Nebreda’s team has published a study in the journal PNAS reporting the involvement of the protein p38 in the progression of lung cancer.

The work shows that patients with low levels of this protein have a better prognosis. 

One of the biggest challenges faced by biomedicine is the development of more selective and efficient cancer treatments.

<p>A massive genomic sequencing and assembly strategy has allowed the scientists to gain the most complete vision of the genomic sequence of this species</p>
20 Dec 2019

This species shows several genetic duplications, which may explain its high plasticity and capacity to adapt to diverse farming conditions.

CSIC has headed this research, which has brought about a considerable advance in the development of genomic and biotechnological tools to achieve more sustainable fish farming.

The findings of the study will be applied in genetic selection and environmental programming in order to improve fish quality and interaction with the microorganisms present in the host environment.

<p>To ensure adequate levels of proteins in the cell, a strict quality control system is responsible for tagging the proteins with ubiquitin for degradation. Francisco Martínez, IRB Barcelona.</p>
2 Dec 2019

Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.

A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.

The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.