The Chemical Checker provides processed, harmonized and ready-to-use bioactivity information on more than 1M small molecules
The tool, developed by the Structural Bioinformatics and Network Biology lab at IRB Barcelona, has been published in Nature Biotechnology.
Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells.
The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.
The Colorectal Cancer Lab at IRB Barcelona identifies the capacity to synthesize proteins (or biosynthetic capacity) as a key property for the regenerative potential of colon cancer cells.
Published in Cell Stem Cell, the study proposes a new therapeutic focus for the scientific community and the pharmaceutical industry to explore.
More than 200 regions (amino acids) in histones are identified as responsible for regulating the response to cell stress.
The study reports that histones undergo distinct modifications depending on the type of cell stress.
The work by the Cell Signaling laboratory has been published in the journal Nucleic Acids Research.
The Centre for Genomic Regulation (CRG) is coordinating a task force with the Institute for Research in Biomedicine (IRB Barcelona) and the Institute for Bioengineering of Catalonia (IBEC), as requested by Generalitat de Catalunya, to set up mass testing for citizens to stop the spread of the new coronavirus outbreak.
There will be two mass testing sites – one coordinated by the CRG at its labs at the Barcelona Biomedical Research Park (PRBB) and another at the Parc Cientific de Barcelona, jointly coordinated by IRB Barcelona, IBEC and the Centro Nacional de Análisis Genómico (CNAG-CRG), part of the CRG.
The project, codenamed Programa Orfeu by the Generalitat de Catalunya...
The HOG signalling pathway regulates the stress response in the yeast Saccharomyces cerevisiae and halts cell division, thereby regulating the segregation of chromosomes through protein Net1.
The p38 signalling pathway in humans is equivalent to that of HOG and is involved in tumour development.
The study by the Signaling Laboratory at IRB Barcelona has been published in the journal PNAS.
· The tool is based on Chemical Checker technology, developed by the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona.
· The aim is to use artificial intelligence to generate a drug database that includes all the published scientific results related to the treatment of COVID-19.
· This open access database will provide researchers from around the world with an expanded portfolio of molecules with the potential to fight COVID-19.
The ICREA researcher at IRB Barcelona obtains €2.5 M to identify residual cells that cause relapse after treatment.
This is the fifth ERC grant awarded to Eduard Batlle, and the 20th at IRB Barcelona.
The study, published in the journal Developmental Cell and performed in Drosophila, unravels how developmental genes regulate organ size and proportions.
Researchers at IRB Barcelona demonstrate that the size and patterning of a given organ are regulated by different mechanisms.
Given the high genetic and mechanistic conservation between flies and humans, these discoveries pave the way for new research lines into congenital malformations and other diseases