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At the forefront of biomedicine

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Research publications

CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
Cano-Crespo S, Chillarón J, Junza A, Fernández-Miranda G, García J, Polte C, R de la Ballina L, Ignatova Z, Yanes Ó, Zorzano A, Stephan-Otto Attolini C, Palacín M
9
1
14065 -
14065
2019
Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
Pittolo S; Lee H; Lladó A; Tosi S; Bosch M; Bardia L; Gómez-Santacana X; Llebaria A; Soriano E; Colombelli J; Poskanzer K; Perea G; Gorostiza P
116
27
13680 -
13689
2019
The Origins and the Biological Consequences of the Pur/Pyr DNA·RNA Asymmetry
Terrazas M; Genna V; Portella G; Villegas N; Sánchez D; Arnan C; Pulido-Quetglas C; Johnson R; Guigó R; Brun-Heath I; Aviñó A; Eritja R; Orozco M
5
6
1619 -
1631
2019
Autophagy-induced senescence is regulated by p38α signaling
Slobodnyuk K; Radic N; Ivanova S; Llado A; Trempolec N; Zorzano A; Nebreda A
10
6
376 -
2019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernadó P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
116
20
10009 -
10018
2019
Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
Terré B; Lewis M; Gil-Gómez G; Han Z; Lu H; Aguilera M; Prats N; Roy S; Zhao H; Stracker TH
146
8
-
2019
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo A; Topal B; Kunze M; Aranda J; Chiesa G; Mungianu D; Bernardo-Seisdedos G; Eftekharzadeh B; Gairí M; Pierattelli R; Felli I; Diercks T; Millet O; García J; Orozco M; Crehuet R; Lindorff-Larsen K; Salvatella X
10
1
2034 -
2019
The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle
Moreno-Moreno O; Torras-Llort M; Azorin F
47
7
3395 -
3406
2019
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Errasti-Murugarren E; Fort J; Bartoccioni P; Díaz L; Pardon E; Carpena X; Espino-Guarch M; Zorzano A; Ziegler C; Steyaert J; Fernández-Recio J; Fita I; Palacín M
10
1
1807 -
2019
Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7
Bartoccioni P; Fort J; Zorzano A; Errasti-Murugarren E; Palacín M
151
4
505 -
517
2019
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle E; Massagué J
50
4
924 -
940
2019
Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit
Picchioni D; Antolin-Fontes A; Camacho N; Schmitz C; Pons-Pons A; Rodríguez-Escribà M; Machallekidou A; Güler MN; Siatra P; Carretero-Junquera M; Serrano A; Hovde SL; Knobel PA; Novoa EM; Solà-Vilarrubias M; Kaguni LS; Stracker TH; Ribas de Pouplana L
27
1
40 -
47.e5
2019
An In-Depth Look at DNA Crystals through the Prism of Molecular Dynamics Simulations
Kuzmanic A; Dans P; Orozco M
5
3
649 -
663
2019
Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics
Colizzi F; Hospital A; Zivanovic S; Orozco M
58
12
3759 -
3763
2019
Self-Sensing Enzyme-Powered Micromotors Equipped with pH-Responsive DNA Nanoswitches
Patino T; Porchetta A; Jannasch A; Lladó A; Stumpp T; Schäffer E; Ricci F; Sánchez S
19
6
3440 -
3447
2019
Modeling, Simulations, and Bioinformatics at the Service of RNA Structure
Dans P; Gallego D; Balaceanu A; Darré L; Gómez H; Orozco M
5
1
51 -
73
2019
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis
Curtis M; Kenny HA; Ashcroft B; Mukherjee A; Johnson A; Zhang Y; Helou Y; Batlle R; Liu X; Gutierrez N; Gao X; Yamada SD; Lastra R; Montag A; Ahsan N; Locasale JW; Salomon AR; Nebreda AR; Lengyel E
29
1
141 -
155.e9
2019
Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock
Amat R; Böttcher R; Le Dily F; Vidal E; Quilez J; Cuartero Y; Beato M; De Nadal E; Posas F
29
1
18 -
28
2019
Encircling the regions of the pharmacogenomic landscape that determine drug response
Fernandez-Torras, Adria; Duran-Frigola, Miquel; Aloy, Patrick
11
17
17 -
2019
Regulation of death receptor signaling by the autophagy protein TP53INP2
Ivanova, Saska; Polajnar, Mira; Jesus Narbona-Perez, Alvaro; Isabel Hernandez-Alvarez, Maria; Frager, Petra; Slobodnyuk, Konstantin; Plana, Natalia; Nebreda, Angel R; Palacin, Manuel; Gomis, Roger R; Behrends, Christian; Zorzano, Antonio
38
10
-
2019
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
Mayor-Ruiz, C.1,*, Jaeger, M.G*, Bauer, S., Brand, M., Sin, C., Hanzl, A., Mueller, A.C., Menche, J., and Winter, G.E.1
1 co-corresponding; *Co-first authors
75
849 -
858
2019
A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana
Anna-Lena Van de Weyer, Freddy Monteiro, Oliver J Furzer, Marc T Nishimura, Volkan Cevik, Kamil Witek, Jonathan D G Jones, Jeffery L Dangl, Detlef Weigel, Felix Bemm
5
178
1260 -
1272.e14
2019
TIR domains of plant immune receptors are NAD +-cleaving enzymes that promote cell death
Li Wan, Kow Essuman, Ryan G Anderson, Yo Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, Aaron DiAntonio, Jeffrey Milbrandt, Jeffery L Dangl, Marc T Nishimura
6455
365
799 -
803
2019
Identification and characterization of cancer vulnerabilities via targeted protein degradation
Mayor-Ruiz, C., and Winter, G.E
31
81 -
90
2019
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
Mayor-Ruiz, C (#) (1), Jaeger, M.G (#), Bauer, S., Brand, M., Sin, C., Hanzl, A., Mueller, A.C., Menche, J., and Winter, G.E (1). (1) Co-corresponding authors; (# Equal contribution)
75
849 -
858
2019
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodriguez-Nuevo, Aida; Diaz-Ramos, Angels; Noguera, Eduard; Diaz-Saez, Francisco; Duran, Xavier; Pablo Munoz, Juan; Romero, Montserrat; Plana, Natalia; Sebastian, David; Tezze, Caterina; Romanello, Vanina; Ribas, Francesc; Seco, Jordi; Planet, Evarist; Doctrow, Susan R; Gonzalez, Javier; Borras, Miquel; Liesa, Marc; Palacin, Manuel; Vendrell, Joan; Villarroya, Francesc; Sandri, Marco; Shirihai, Orian; Zorzano, Antonio
37
10
-
2018
Citizen science charts two major "stomatotypes" in the oral microbiome of adolescents and reveals links with habits and drinking water composition
Willis JR, González-Torres P, Pittis AA, Bejarano LA, Cozzuto L, Andreu-Somavilla N, Alloza-Trabado M, Valentín A, Ksiezopolska E, Company C, Onywera H, Montfort M, Hermoso A, Iraola-Guzmán S, Saus E, Labeeuw A, Carolis C, Hecht J, Ponomarenko J, Gabaldón T
6
1
218 -
218
2018
Toward quantitative three-dimensional microvascular networks segmentation with multiview light-sheet fluorescence microscopy
Kennel, Pol; Teyssedre, Lise; Colombelli, Julien; Plouraboue, Franck
23
8
1 -
14
2018
3D imaging of cleared human skin biopsies using light-sheet microscopy: A new way to visualize in-depth skin structure
Abadie, S; Jardet, C; Colombelli, J; Chaput, B; David, A; Grolleau, J -L; Bedos, P; Lobjois, V; Descargues, P; Rouquette, J
24
2
294 -
303
2018
Senescence promotes invivo reprogramming through p16(INK4a) and IL-6
Mosteiro, Lluc; Pantoja, Cristina; de Martino, Alba; Serrano, Manuel
17
2
-
2018
Targeting senescence
Serrano, Manuel; Barzilai, Nir
24
8
1092 -
1094
2018
AAVvector-mediated in vivo reprogramming into pluripotency
Senis, Elena; Mosteiro, Lluc; Wilkening, Stefan; Wiedtke, Ellen; Nowrouzi, Ali; Afzal, Saira; Fronza, Raffaele; Landerer, Henrik; Abad, Maria; Niopek, Dominik; Schmidt, Manfred; Serrano, Manuel; Grimm, Dirk
9
2651
2651 -
2018
Direct Evidence of the Presence of Cross-Linked A beta Dimers in the Brains of Alzheimer's Disease Patients
Vazquez de la Torre, Aurelio; Gay, Marina; Vilaprinyo-Pascual, Silvia; Mazzucato, Roberta; Serra-Batiste, Montserrat; Vilaseca, Marta; Carulla, Natalia
90
7
4552 -
4560
2018
Morphogenetic movements affect local tissue organisation during embryonic Drosophila morphogenesis
Letizia, Annalisa; Tosi, Sebastien; Llimargas, Marta
97
4
243 -
256
2018
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
Claudia Salzer, Marion; Lafzi, Atefeh; Berenguer-Llergo, Antoni; Youssif, Catrin; Castellanos, Andres; Solanas, Guiomar; Oliveira Peixoto, Francisca; Stephan-Otto Attolini, Camille; Prats, Neus; Aguilera, Monica; Martin-Caballero, Juan; Heyn, Holger; Aznar Benitah, Salvador
175
6
1575 -
+
2018
Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst
Salomó E; Gallen A; Sciortino G; Ujaque G; Grabulosa A; Lledós A; Riera A; Verdaguer X
140
49
16967 -
16970
2018
Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues
Benhra N; Barrio L; Muzzopappa M; Milán M
47
2
161 -
174.e4
2018
Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes
Pich O; Muiños F; Sabarinathan R; Reyes-Salazar I; Gonzalez-Perez A; Lopez-Bigas N
175
4
1074 -
1087.e18
2018
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Bouchard J; Otero J; Scott D; Szulc E; Martin E; Sabri N; Granata D; Marzahn M; Lindorff-Larsen K; Salvatella X; Schulman B; Mittag T
72
1
19 -
36.e8
2018
Centrobin is essential for c-tubule assembly and flagellum development in drosophila melanogaster spermatogenesis
Reina J; Gottardo M; Riparbelli M; Llamazares S; Callaini G; Gonzalez C
217
7
2365 -
2372
2018
The evolutionary signal in metagenome phyletic profiles predicts many gene functions
Vidulin V; Šmuc T; Džeroski S; Supek F
6
1
129 -
2018
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Youssif C; Cubillos-Rojas M; Comalada M; Llonch E; Perna C; Djouder N; Nebreda A
10
7
-
2018
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
Romero M; Sabaté-Pérez A; Francis VA; Castrillón-Rodriguez I; Díaz-Ramos Á; Sánchez-Feutrie M; Durán X; Palacín M; Moreno-Navarrete JM; Gustafson B; Hammarstedt A; Fernández-Real JM; Vendrell J; Smith U; Zorzano A
20
4
443 -
454
2018
Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth
Campbell K; Lebreton G; Franch-Marro X; Casanova J
14
2
e1007167 -
2018
Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
Miret-Casals L; Sebastián D; Brea J; Rico-Leo E; Palacín M; Fernández-Salguero P; Loza M; Albericio F; Zorzano A
25
3
268 -
278.e4
2018
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
Duch A; Canal B; Barroso S; García-Rubio M; Seisenbacher G; Aguilera A; De Nadal E; Posas F
9
1
379 -
2018
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
De Mol E; Szulc E; Di Sanza C; Martínez-Cristóbal P; Bertoncini C; Fenwick R; Frigolé-Vivas M; Masín M; Hunter I; Buzón V; Brun-Heath I; García J; De Fabritiis G; Estébanez-Perpiñá E; McEwan I; Nebreda Á; Salvatella X
26
1
145 -
152.e3
2018
Adherens Junction Length during Tissue Contraction Is Controlled by the Mechanosensitive Activity of Actomyosin and Junctional Recycling
Sumi, Angughali; Hayes, Peran; D'Angelo, Arturo; Colombelli, Julien; Salbreux, Guillaume; Dierkes, Kai; Solon, Jerome
47
4
453 -
+
2018