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Research

At the forefront of biomedicine

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Research publications

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Mateo L; Duran-Frigola M; Gris-Oliver A; Palafox M; Scaltriti M; Razavi P; Chandarlapaty S; Arribas J; Bellet M; Serra V; Aloy P
12
1
78 -
2020
Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter
Pittis AA; Goh V; Cebrian-Serrano A; Wettmarshausen J; Perocchi F; Gabaldón T
11
1
4031 -
2020
A compendium of mutational cancer driver genes
Martínez-Jiménez F; Muiños F; Sentís I; Deu-Pons J; Reyes-Salazar I; Arnedo-Pac C; Mularoni L; Pich O; Bonet J; Kranas H; Gonzalez-Perez A; Lopez-Bigas N
20
10
555 -
572
2020
Manipulating the Mediator complex to induce naïve pluripotency
Lynch CJ; Bernad R; Calvo I; Serrano M
395
2
112215 -
2020
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte D; Supek F
52
9
958 -
+
2020
Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells
Cash TP; Alcalá S; Rico-Ferreira MDR; Hernández-Encinas E; García J; Albarrán MI; Valle S; Muñoz J; Martínez-González S; Blanco-Aparicio C; Pastor J; Serrano M; Sainz B
12
7
1 -
25
2020
Probing the Kinetic and Thermodynamic Fingerprints of Anti-EGF Nanobodies by Surface Plasmon Resonance
Guardiola, Salvador; Varese, Monica; Taules, Marta; Diaz-Lobo, Mireia; Garcia, Jesus; Giralt, Ernest;
13
6
1 -
10
2020
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Salvadores, Marina; Fuster-Tormo, Francisco; Supek, Fran
6
27
-
2020
Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism
Sebastián D; Zorzano A
54
2
268 -
281
2020
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue C; Cubillos-Rojas M; Gutierrez-Prat N; Sanchez-Zarzalejo C; Verdaguer X; Riera A; Nebreda AR
201
112451
112451 -
2020
The NEUBIAS Gateway: A hub for bioimage analysis methods and materials
Miura K; Cimini BA; Nørrelykke SF; Louveaux M; Sladoje N; Paul-Gilloteaux P; Colombelli J
9
613 -
2020
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
Dziubańska-Kusibab PJ; Berger H; Battistini F; Bouwman BAM; Iftekhar A; Katainen R; Cajuso T; Crosetto N; Orozco M; Aaltonen LA; Meyer TF
26
7
1063 -
+
2020
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Duran-Frigola, M; Pauls, E; Guitart-Pla, O; Bertoni, M; Alcalde, V; Amat, D; Juan-Blanco, T; Aloy, P
38
9
1087 -
+
2020
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer
Morral C; Stanisavljevic J; Hernando-Momblona X; Mereu E; Álvarez-Varela A; Cortina C; Stork D; Slebe F; Turon G; Whissell G; Sevillano M; Merlos-Suárez A; Casanova-Martí À; Moutinho C; Lowe SW; Dow LE; Villanueva A; Sancho E; Heyn H; Batlle E
26
6
845 -
+
2020
LOBSTER: an environment to design bioimage analysis workflows for large and complex fluorescence microscopy data
Tosi S; Bardia L; Filgueira MJ; Calon A; Colombelli J
36
8
2634 -
2635
2020
A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress
Viéitez C; Martínez-Cebrián G; Solé C; Böttcher R; Potel CM; Savitski MM; Onnebo S; Fabregat M; Shilatifard A; Posas F; de Nadal E
48
7
3455 -
3475
2020
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Pascual, Rosa; Martin, Judit; Salvador, Fernando; Reina, Oscar; Chanes, Veronica; Millanes-Romero, Alba; Suner, Clara; Fernandez-Miranda, Gonzalo; Bartomeu, Anna; Huang, Yi-Shuian; Gomis, Roger R; Mendez, Raul
6
20
eaax3868 -
2020
Hog1 activation delays mitotic exit via phosphorylation of Net1
Tognetti S; Jiménez J; Viganò M; Duch A; Queralt E; de Nadal E; Posas F
117
16
8924 -
8933
2020
Imaging the Cell Morphological Response to 3D Topography and Curvature in Engineered Intestinal Tissues
Altay G; Tosi S; García-Díaz M; Martínez E
8
294
294 -
2020
A reference map of the human binary protein interactome
Luck K; Kim DK; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Coté AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin SF; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; Luck K; Kim DK; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Coté AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin SF; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; Luck K; Kim DK; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T
580
7803
402 -
+
2020
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Sati S; Bonev B; Szabo Q; Jost D; Bensadoun P; Serra F; Loubiere V; Papadopoulos GL; Rivera-Mulia JC; Fritsch L; Bouret P; Castillo D; Gelpi JL; Orozco M; Vaillant C; Pellestor F; Bantignies F; Marti-Renom MA; Gilbert DM; Lemaitre JM; Cavalli G
78
3
522 -
+
2020
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
Sridhar A; Farr SE; Portella G; Schlick T; Orozco M; Collepardo-Guevara R
117
13
7216 -
7224
2020
Synthesis and Application of 3-Bromo-1,2,4,5-Tetrazine for Protein Labeling to Trigger Click-to-Release Biorthogonal Reactions
Ros E; Bellido M; Verdaguer X; De Pouplana LR; Riera A
31
3
933 -
938
2020
P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis
Cabré A; Riera A; Verdaguer X
53
3
676 -
689
2020
Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols
Cabré A; Rafael S; Sciortino G; Ujaque G; Verdaguer X; Lledós A; Riera A
59
19
7521 -
7527
2020
From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy
Kennel P; Dichamp J; Barreau C; Guissard C; Teyssedre L; Rouquette J; Colombelli J; Lorsignol A; Casteilla L; Plouraboué F
16
2
e1007322 -
2020
A multi-modal coarse grained model of DNA flexibility mappable to the atomistic level
Walther J; Dans PD; Balaceanu A; Hospital A; Bayarri G; Orozco M
48
5
2020
Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers
Barrio L; Milán M
52
5
659 -
+
2020
The mitochondrial tRNA conundrum
de Pouplana LR
21
7
361 -
361
2020
Gene gain and loss across the metazoan tree of life
Fernández R, Gabaldón T
4
4
524 -
533
2020
The embryonic linker histone dBigH1 alters the functional state of active chromatin
Climent-Cantó P, Carbonell A, Tatarski M, Reina O, Bujosa P, Font-Mateu J, Bernués J, Beato M, Azorín F
48
8
4147 -
4160
2020
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Vitos-Faleato J, Real SM, Gutierrez-Prat N, Villanueva A, Llonch E, Drosten M, Barbacid M, Nebreda AR
117
5
2588 -
2596
2020
Characterization of Human Sperm Protamine Proteoforms through a Combination of Top-Down and Bottom-Up Mass Spectrometry Approaches
Soler-Ventura A; Gay M; Jodar M; Vilanova M; Castillo J; Arauz-Garofalo G; Villarreal L; Ballescà JL; Vilaseca M; Oliva R
19
1
221 -
237
2020
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C*, Feucht J*, Leibold J*, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, et al, Sadelain M, Lowe SW. (*equal contribution).
2020
An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
Paz Zafra M, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E and Dow LE.
2020
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Rosa Pascual, Judit Martín, Fernando Salvador, Oscar Reina, Veronica Chanes, Alba Millanes-Romero, Clara Suñer, Gonzalo Fernández-Miranda, Anna Bartomeu, Yi-Shuian Huang, Roger R Gomis, Raúl Méndez
6
eaax3868
2020
Rational discovery of molecular glue degraders via scalable chemical profiling
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E
2020
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Alejo E Rodriguez-Fraticelli, Caleb S Weinreb, Shou Wen Wang, Rosa P Migueles, Maja Jankovic, Marc Usart, Allon M Klein, Sally Lowell, Fernando D Camargo
2020
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Caleb S Weinreb(#), Alejo E Rodriguez-Fraticelli(#), Fernando D Camargo, Allon M Klein (# Equal contribution)
2020
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Isabel Hernandez-Alvarez, Maria; Sebastian, David; Vives, Sara; Ivanova, Saska; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sonia R.; Hernandez, Vanessa; Vasconcelos, Nuno; Peddinti, Gopal; Adrover, Anna; Jove, Mariona; Pamplona, Reinald; Gordaliza-Alaguero, Isabel; Calvo, Enrique; Cabre, Noemi; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Rodrigues, Cecilia M. P.; Orozco, Modesto; Joven, Jorge; Canto, Carles; Palacin, Manuel; Fernandez-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio;
177
4
881 -
+
2019
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Eftekharzadeh B; Banduseela V; Chiesa G; Martínez-Cristóbal P; Rauch J; Nath S; Schwarz D; Shao H; Marin-Argany M; Di Sanza C; Giorgetti E; Yu Z; Pieratelli R; Felli I; Brun-Heath I; García J; Nebreda Á; Gestwicki J; Lieberman A; Salvatella X
10
3562
3562 -
2019
The Expansion of Inosine at the Wobble Position of tRNAs, and Its Role in the Evolution of Proteomes
Rafels-Ybern, Albert; Gabriel Torres, Adrian; Camacho, Noelia; Herencia-Ropero, Andrea; Roura Frigole, Helena; Wulff, Thomas F; Raboteg, Marina; Bordons, Albert; Grau-Bove, Xavier; Ruiz-Trillo, Inaki; Ribas de Pouplana, Lluis
36
4
650 -
662
2019
Evolutionary and functional patterns of shared gene neighbourhood in fungi
Marcet-Houben M; Gabaldón T
4
12
2383 -
2392
2019
The mutational footprints of cancer therapies
Pich O; Muiños F; Lolkema M; Steeghs N; Gonzalez-Perez A; Lopez-Bigas N
51
12
1732 -
+
2019
OncodriveCLUSTL: A sequence-based clustering method to identify cancer drivers
Arnedo-Pac C; Mularoni L; Muiños F; Gonzalez-Perez A; Lopez-Bigas N; Schwartz R
35
22
4788 -
4790
2019
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom RGH; Vermeulen M; Lehner B; Supek F
51
11
1645 -
+
2019
Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
Aragón E; Wang Q; Zou Y; Morgani SM; Ruiz L; Kaczmarska Z; Su J; Torner C; Tian L; Hu J; Shu W; Agrawal S; Gomes T; Márquez JA; Hadjantonakis AK; Macias MJ; Massagué J
33
21-22
1506 -
1524
2019
Inducible slc7a7 knockout mouse model recapitulates lysinuric protein intolerance disease
Bodoy S; Sotillo F; Espino-Guarch M; Sperandeo MP; Ormazabal A; Zorzano A; Sebastio G; Artuch R; Palacín M
20
21
-
2019