A bioinformatics analysis of pairing 64 drugs used to treat breast cancer allows researchers at IRB Barcelona to identify 10 previously untested combinations with potential to tackle resistance to breast cancer treatment.
In spite of the many drugs available to treat breast cancer, resistance continues to be a problem.
EFE Agency has echoed the research performed by Carles Pons, Research Associate in Patrick Aloy's lab (Structural Bioinformatics and Network Biology) at IRB Barcelona, recently published in Science. The study presents the first comprehensive set of suppressive mutations in a cell. Its findings could help “explain how suppressive mutations combine with disease-causing mutations to soften the blow of a disease, or even completely protect against it”.
Link to EFE Agency
Eduard Batlle’s work on colon cancer and Patrick Aloy’s on the network biology of Alzheimer’s disease feature among the newspaper El Mundo’s list of the most promising ten lines of research performed in labs in Spain. These ten labs are recognised as having the capacity to provide new pieces of the puzzle and transform some aspects of our everyday lives. The newspaper drew up the list on the occasion of Researchers’ Night.
Turkish-born Emre Güney (Izmir, 1983) joined IRB Barcelona in October 2015 as a Beatriu de Pinós Postodoctoral Fellow. Supporting the best young scientists, these highly competitive 2-year fellowships awarded by the Catalan Government allow them to choose the centre where they want to carry out their research project.
ICREA Researcher Patrick Aloy, leader of the Structural Bioinformatics and Network Biology group, has spoken with La Vanguardia about animal testing and what alternatives exist to reduce it. He and his team have developed two computer methods to predict which molecules could have negative effects in an organism, using the enormous quantity of data generated by the clinical essays in the last decades....
The trilingual magazine of the city of Barcelona, Barcelona Metropolis, dedicates its leading article and an extensive report to the biomedicine conducted in Barcelona. Various articles in this edition address topics related to this discipline, ranging from biomedicine as a business model and associated research fields, such as biomedical chemistry or big data, to key institutions such as the Catalan Institution for Research and Advanced Studies (ICREA).
IRB Barcelona is well represented in the magazine, with references and statements by Joan Guinovart, director of the institute, Patrick Aloy, Eduard Batlle, Natàlia Carulla, Ernest Giralt, Modesto Orozco, and Xavier Salvatella,...
Cristina Sáez, a journalist specialised in science, wrote this long article on Alzheimer’s disease, published in The Magazine of La Vanguardia. The article includes statements, among others, of various scientists specialised in this disease, including Natàlia Carulla, Ramón y Cajal associate researcher in the Peptide and Protein Laboratory, and Patrick Aloy, ICREA researcher and group leader of the Structural Bioinformatics and Network Biology Laboratory, at IRB Barcelona.
Read the article in The Magazine (in Spanish)
The “Gaceta Médica” newspaper has published an article about the computational resource dSysMap, developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelona, led by ICREA researcher Patrick Aloy. The article includes statements by Aloy. This tool, which associates genetic mutations with various complex diseases, was presented in the journal Nature Methods and has been included in the international consortium Pan-Cancer for the analysis of human tumours.
The computational tool developed by the Laboratory of Structural Bioinformatics and Network Biology at IRB Barcelona, led by ICREA researcher Patrick Aloy, associates 23,000 genetic mutations with various complex diseases such as cancer, Alzheimer’s and diabetes. The presentation of the dSysMap tool in the journal Nature Methods, and its inclusion in the international consortium Pan-Cancer for the analysis of human tumours have had a considerable impact in the media, among these the “Diari de Girona”.