Structural biology of protein & nucleic acid complexes and molecular machines news

<p>3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon</p>
11 Sep 2017

The radio programme of RNE Laboratorio de Jal has referred to the study of Miquel Coll’s group on the resistance of Staphylococcus aureus to antibiotics. This lethal bacterium has a mechanism by which antibiotic resistance genes are transferred.

Thanks to the resolution of a three-dimensional structure of the complex formed by relaxase with a fragment of the plasmid DNA, the researchers have identified an amino acid as a pivotal element of the transfer.

Link to ...

<p>3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon</p>
26 Jul 2017

Scientists at IRB Barcelona identify a key component of the machinery that allows Staphylococcus aureus to transfer genes that confer antibiotic resistance. 

Infection by antibiotic-resistant S. aureus is a serious threat in hospitals worldwide.

Halting the spread of antibiotic-resistant bacteria is one of the strategies available to tackle hospital infections.

2 Dec 2014

Excelenciencia.org has published an article that includes statements made by Manuel Palacín after the “Transporters and other Molecular Machines” conference, part of Barcelona Biomed Conferences, which is organised by IRB Barcelona with the support of the BBVA Foundation.

Hosted by IRB Barcelona researchers Manuel Palacín and Miquel Coll, this conference addressed the latest technological advances in membrane protein determination. Given that many of these proteins have the capacity to enter cells, the determination of their structures may allow the design of smart drugs for many types of diseases.

21 Nov 2014

Article on the Barcelona BioMed conference on membrane proteins, organised by IRB Barcelona and the BBVA Foundation. According to statements made by the organisers Manuel Palacín and Miquel Coll, both at IRB Barcelona, research into the structure of these proteins "paves the way to a wide range of possibilities for the development of new drugs for diseases that currently have no cure and to search for alternative treatments in other conditions for which current drugs are not overly efficient or...

17 Nov 2014

30% of human proteins exert their function in cell membranes and more than 50% act on these proteins.

New high-resolution microscopes and 3D calculation programmes are crucial to increase the number of atomic structures available, which currently stands at 440, this figure representing 3% of the estimated 15,000 that exist.

Today sees the start of a three-day conference in Barcelona involving 150 international scientists invited by the BBVA Foundation and IRB Barcelona.

9 Mar 2014

Article by ARA newspaper on crystallography, a technique that reveals the 3D structure of organic material, such as proteins. The journalist Mònica L. Ferrado has consulted IRB researcher Miquel Coll, an international authority on this technique and on research into nucleic acids and proteins.

Read the...

28 Feb 2014

Prof. John Halliwell, chemist at the University of Manchester, devotes an article to Roeland Boer & Miquel Coll's paper published in Cell on plant development. The breakthrough was possible by using the Synchrotron Alba beam light facility and was a collaboration with Prof. Dolf Weijers at the University of Wageningen, in the Netherlands.

Read the article here: Alba News (PDF)

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8 Feb 2014

Prof. Miquel Coll, structural biologist and programme coordinator at IRB Barcelona, is interviewed about the art of crystallography on the science radio programme "Principio de Incertidumbre" on Canal Extremadura, to mark the international year of crystallography.

The 30-minute interview goes into the basic concepts behind organic molecules, proteins and nucleic acids, and the importance of their atomic composition to reveal 3D structures and the later design of pharmaceutical agents. Coll explains the ins and outs of crystallography, the most widely used techniques to attain 3D structures, and the applications...

2 Feb 2014

In the section "ARA Ciencia", part of the newspaper "ARA", reports on a breakthrough about plant development achieved by IRB/CSIC researchers headed by Miquel Coll at IRB Barcelona.

The scientists have described the molecular mechanism by which the auxin hormones regulate plant growth and development. The journal "Cell" published the results of the study on 30 January. The resolution of the 3D structure in the ALBA synchrotron and the ESRF synchrotron in Grenoble has revealed the ultimate effect of auxin hormones on DNA for the control of distinct functions in the growth and...

<p>Arabidopsis thaliana is model with which to study the molecular biology of many plant traits (Wikimedia Commons))</p>
30 Jan 2014

Researchers at IRB and IBMB-CSIC, in Barcelona, and at the University of Wageningen, in the Netherlands, reveal how auxin hormone-regulated proteins activate developmental genes in plants.

Auxins are key components of plant growth and have many applications in agriculture. The biomedical application of these hormones are also being addressed.

The study is published this week in the scientific journal Cell.