Results about: ageing
Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries.
How does the circadian clock change when we get older? This is the question that has driven research associate Guiomar Solanas and “la Caixa” PhD student Francisca Oliveira Peixoto, both at IRB Barcelona, to study the daily pattern of gene activity. The answer, as laid out in two studies headed by Salvador Aznar Benitah and published in the journal Cell, rejects the widely held belief that stem cells lose their circadian rhythm with age. The studies demonstrate that the daily pattern of gene activity is not lost with age but is rather reprogrammed for new functions and that a low calorie diet delays alterations in the rhythm of stem cells.
Stem cell functions continue to be governed by day and night cycles (circadian rhythms) during ageing, but their rhythms become devoted to tissue repair and not to the maintenance of tissue tone.
The two studies published in Cell and headed by Salvador Aznar Benitah at IRB Barcelona reject the scientific dogma associating ageing with the loss of stem cell circadian rhythm.
A low-calorie diet delays alterations in the rhythmic functions of stem cells and slows down ageing.
Manuel Serrano from CNIO was one of the ten invited speakers who participated in the IRB Barcelona PhD Symposium on 12-13 November. The event attracted many young and senior scientists from all over Europe and covered a wide range of themes. The next event of the series will take place in 2017.