Results about: Alzheimer’s Disease
The findings of an IRB Barcelona study challenge a scientific principle about amyloid beta, a protein linked to Alzheimer’s disease
Natàlia Carulla’s research group provides information that questions the widely accepted premise regarding the number of molecules and the shape of the first aggregates formed by amyloid beta protein
Amyloid beta protein aggregation, the process by which molecules of this protein adhere to each other is strongly associated with the development of Alzheimer’s disease
Carulla’s work ultimately seeks to identify molecules that interfere with the initial stages of aggregation as a strategy to combat the disease.
A study done on fruit flies and published in Nature Communications reveals that the protein dDsk2, in addition to degrading proteins, also plays a key role in regulating gene expression.
This protein is also present in humans and is known to be mutated in several neurodegenerative diseases, including Alzheimer’s. But the mechanism by which these mutations contribute to the development of disease remains unclear.
IRB Barcelona is to start a study to examine the relationship between dDsk2 mutations and neurodegenerative diseases.
Next Saturday, IRB Barcelona is set to receive hundreds of people who have shown interest in the centre after the fund-raising dance video featuring its researchers.
Those who have given donations include schools and members of the public curious about the institute’s facilities, which are located at the Barcelona Science Park.
Almost 150 volunteers will be participating in the event, held to mark IRB Barcelona’s 10th anniversary this year.