Results about: autophagy

<p>Antonio Zorzano, head of the Complex Metabolic Diseases and Mitochondria Lab</p>

Age-related metabolic diseases have increased to epidemic proportions in all industrialized countries.

DOR protein deficiency favours the development of obesity

Researchers at IRB Barcelona discover the mechanism that leads to a less harmful form of obesity that is associated with the number rather than volume of fat cells.

There are several types of obesity and some are more harmful than others.

The study has been published in the journal Nature Cell Biology.

Nobel Prize for research into cell “recycling”

This year the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi, a Japanese biologist who discovered autophagy—the process used by cells to clean and recycle their components. Group Leader Antonio Zorzano studies autophagy in his research at IRB Barcelona, and explains why it is such a key discovery in an interview published in La Vanguardia.

 

 

The absence of a single protein spurs muscle aging in mice

IRB Barcelona researchers discover that the loss of the protein Mitofusin 2 in the muscles of young mice speeds up aging and causes early sarcopenia, thus leading to the muscle quality of aged mice.

Sarcopenia, which is muscle wastage and the accompanied loss of strength, is one of the most weakening conditions of old age and it has no treatment.

The scientists propose that stimulating Mitofusin 2 activity would provide a good strategy through which to ameliorate sarcopenia.

Identified a new possible target to combat muscle wasting

Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice.

The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia.