Results about: beta-sheets

“Find something that truly motivates you, everything else will come naturally”

Postdoc Enrique Marcos (Barcelona 1982) is a chemist, a theoretical chemist to be exact. He has just published his first paper in Science, in which he explains how to computationally design the pocket-like cavities of proteins—essential areas that allow many proteins to perform their functions. And he has just been awarded a second Marie Skłodowska-Curie Action Fellowship.

 

The findings of an IRB Barcelona study challenge a scientific principle about amyloid beta, a protein linked to Alzheimer’s disease

Natàlia Carulla’s research group provides information that questions the widely accepted premise regarding the number of molecules and the shape of the first aggregates formed by amyloid beta protein

Amyloid beta protein aggregation, the process by which molecules of this protein adhere to each other is strongly associated with the development of Alzheimer’s disease

Carulla’s work ultimately seeks to identify molecules that interfere with the initial stages of aggregation as a strategy to combat the disease.

The transmission of information via proteins could revolutionize drug discovery

A study by the scientists Xavier Salvatella and Modesto Orozco at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.

Published in Nature Communications, the article furthers a key theoretical field for drug discovery, as it would allow the discovery of many more drug binding sites in proteins of biomedical interest.