Results about: bioinformatics
Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the KTH Royal Institute of Technology in Stockholm develop a new method that predicts the way in which proteins move to exert their biological functions.
They have demonstrated that protein movement is governed by the general shape of these molecules, thereby providing new data on how proteins work—a key step for drug development.
Stephan-Otto: “In the near future, there’s going to be one biostatistician in every biomedical laboratory”
Camille Stephan-Otto Attolini, who holds a PhD in Biomathematics, heads the Biostatistics and Bioinformatics Core Facility at IRB Barcelona.
The “Meet Our Scientists” video “Deciphering the bytes of life” explains her work and shows us the personal side of this scientist.
IRB Barcelona is to coordinate a Horizon2020 bioinformatics project that seeks to lay the groundwork for the emerging field of 3D genomics.
3D genomics provides information about the structures adopted by folded DNA inside a cell and about how they change over time and in response to alterations in cell environment. Modesto Orozco, the coordinator of the project says, “The 3D perspective will allow us to better relate changes in the genome with the corresponding diseases, because although 1D information is relevant, it falls short.”
Over three years, the project aims to provide a set of methods and integrated databases that can be used to store and process the data deriving from studies devoted to 3D genomics.
The European consortium comprises six international leading centres in method development and visualisation in 3D genomics.
The National Bioinformatics Institute (INB) acts as the Spanish scientific node and coordinates the partner institutions. These comprises CNIO, CRG, UPF, BSC and IRB Barcelona
A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia (CLL)
CLL is the most frequent leukemia with more than 12,000 new cases diagnosed in Europe every year
IRB Barcelona group leader Modesto Orozco participated in the study as he is involved with the International Cancer Genome Consortium (ICGC)