Results about: blood brain barrier

New Trojan horses to conquer the brain

It has been known for 100 years that the brain is protected by thousands of tight capillaries that form a barrier—a defence mechanism but also an obstacle to the use of promising drugs to treat diseases affecting the central nervous system.

Ernest Giralt: “This barrier is responsible for the low success rate of new drugs to enter the brain. We now have the strategies to overcome it.”

20 pioneering scientists present their latest research on the barrier and the breakthroughs in therapeutic shuttle transporters that target the brain in the Blood-Brain-Barrier Conference, an event organised by IRB Barcelona and supported by the BBVA Foundation.

One of the latest results is a shuttle based on bee venom developed at IRB Barcelona.

“Ambulances for the brain”

Ernest Giralt is to give a public conference at the Centre de Cultura Contemporània de Barcelona on Tuesday 29 September at 19h.

In front of a non-specialized audience, he will present the innovative research being done to overcome the blood-brain barrier and to provide drug treatments for neurological diseases.

Ambulances for the brain supported by the RecerCaixa Programme

Gate2Brain is one of the projects to receive research funding from the Obra Social “la Caixa”

The results of the IRB Barcelona project could have applications in various neurodegenerative diseases

Of the 221 projects presented, only 26 have been awarded funding

An “ambulance” for the brain

Chemists at IRB Barcelona patent and present a shuttle capable of transporting molecules into the brain; this achievement could facilitate the treatment of diseases with no therapy available.

98% of drugs targeting the central nervous system are discarded because they are unable to cross the physical barrier that protects the brain.

The IRB Barcelona scientists, together with clinical teams, are now evaluating the potential of their shuttle for rare and orphan diseases.