Results about: brain

The group directed by Prof. Guinovart is involved in several projects on glycogen metabolism and its dysfunctions in diabetes and Lafora disease.

Discovery of a key protein involved in the development of autism

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism

Published in Nature, the study indicates that a defect in CPEB4 could be the link between environmental factors that alter brain development and the genes that determine susceptibility to autism

Enzyme may be a therapeutic target for breast cancer and brain condition

A new study in collaboration with the Genomic Instability and Cancer Laboratory at IRB Barcelona and led by the University of Copenhagen,  reveals that TLK2 displays lower levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive.

The study suggests that the enzyme may be a target for potential therapies. 

New regulator of neuron formation identified

Researchers at IRB Barcelona reveal that the protein NEK7 is relevant for the correct formation of neurons in the hippocampus, a region of the brain associated with memory.

Animals without NEK7 may also have defects in other other brain regions.

A small group of neurons modulates the amount of insulin that the pancreas must produce

A study co-led by IRB Barcelona and IDIBAPS emphasizes the importance of the neuronal mechanisms in the detection of nutrients and the control of glucose levels.

The results published in Cell Metabolism help to understand diabetes in greater detail.