Results about: brain

The group directed by Prof. Guinovart is involved in several projects on glycogen metabolism and its dysfunctions in diabetes and Lafora disease.

Enzyme may be a therapeutic target for breast cancer and brain condition

A new study in collaboration with the Genomic Instability and Cancer Laboratory at IRB Barcelona and led by the University of Copenhagen,  reveals that TLK2 displays lower levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive.

The study suggests that the enzyme may be a target for potential therapies. 

New regulator of neuron formation identified

Researchers at IRB Barcelona reveal that the protein NEK7 is relevant for the correct formation of neurons in the hippocampus, a region of the brain associated with memory.

Animals without NEK7 may also have defects in other other brain regions.

A small group of neurons modulates the amount of insulin that the pancreas must produce

A study co-led by IRB Barcelona and IDIBAPS emphasizes the importance of the neuronal mechanisms in the detection of nutrients and the control of glucose levels.

The results published in Cell Metabolism help to understand diabetes in greater detail.

Sights set on the next generation of shuttle peptides to target the brain

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently.

IRB Barcelona is one of the few centres worldwide with a specific line of research devoted to this field, which brings together chemistry, pharmacy and biomedicine.

The article appears on the cover of the journal Chemical Society Reviews.

Microscopy moves towards “nanoscopy” and transforms the life sciences

The new microscopes allow the tracking of cell movement within an organism, observation of neuronal synapses, visualization of the spread of cancer, and in vivo monitoring of embryo development.

The development of the 3D microscopy, super-resolution microscopy, and light sheet microscopy (a kind of microscope that illuminates the sample with a sheet of light) pushes biology towards new horizons.

IRB Barcelona and the Centre for Genomic Regulation (CRG) gather 420 experts in the 15th ELMI Meeting, an annual European microscopy congress held this year in Sitges from 19 till 22 May.